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Pharmaceutics /
Remington Education: Pharmaceutics covers the basic principles of pharmaceutics, from dosage forms to drug delivery and targeting. It addresses all the principles covered in an introductory pharmacy course. As well as offering a summary of key information in pharmaceutics, it offers numerous case st...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Pharmaceutical Press,
[2014]
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| Colección: | Remington education.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover
- Half Title
- Remington Education
- Title Page
- Copyright
- Table of Contents
- Preface
- About the author
- Acknowledgments
- 1 Introduction to dosage form design
- Introduction
- Properties of the drug
- Qualities of the ideal dosage form
- Pharmaceutical necessities
- Properties of the routes of administration
- Routes of administration
- Liberation, absorption, distribution, metabolism and elimination (LADME)
- Selected reading
- 2 Intermolecular forces and the physical and pharmaceutical properties of drugs
- Introduction
- Solid state, forces between ions and molecules, and physical properties of drugs
- Surface interactions and the pharmaceutical properties of drugs
- Solubility and dissolution
- Partitioning behavior of drug molecules: Log P
- Dissolution of solids
- Selected reading
- 3 Dispersed systems
- Introduction
- Behavior of molecular solutions, colloidal dispersions, and coarse dispersions
- Flow and viscosity
- Questions and cases
- Selected reading
- 4 Properties of solutions and manipulation of solubility
- Introduction
- Colligative properties of molecular solutions
- Manipulation of solubility
- Selected reading
- 5 Chemical stability of drugs
- Introduction
- Common pathways of drug degradation
- Small drug molecules
- Oxidation
- Photolysis
- Racemization
- Protein drug degradation
- Rates of drug degradation reactions
- Managing chemical stability problems
- Selected reading
- 6 Drug travel from dosage form to receptor
- Introduction
- Physicochemical factors
- Water solubility
- Log P
- Log D
- pH/pKa
- Molecular weight
- Biological factors
- Membrane structure and transport mechanisms
- Movement of drugs across membranes
- Blood flow, tissue perfusion, and other modes of distribution
- Tissue and plasma protein binding
- Drug metabolism (Table 6.5).
- Dosage form factors
- Patient factors
- Selected reading
- 7 Bioavailability, bioequivalence and the Biopharmaceutical Classification System
- Introduction
- Pharmaceutical equivalence + bioequivalence = therapeutic equivalence
- Bioavailability
- Bioequivalence of systemically available drug products
- Biopharmaceutical Classification System
- Biopharmaceutical Drug Disposition Classification System
- Selected reading
- 8 Parenteral drug delivery
- Introduction
- Characteristics of parenteral administration routes
- Parenteral dosage forms
- Preparation and handling of parenteral products
- Parenteral stability/compatibility
- Patient counseling
- Selected reading
- 9 Delivery of biopharmaceuticals and the use of novel carrier systems
- Introduction
- Physicochemical and biological properties
- Movement from administration site to target
- Design of delivery systems
- Biosimilars
- Selected reading
- 10 Drug delivery to the eye
- Introduction
- Characteristics of the ophthalmic route
- Drug properties and the eye
- Dosage forms for the ophthalmic route (Table 10.3)
- Counseling patients
- Ophthalmic ointment and gels
- Selected reading
- 11 Drug delivery to and from the oral cavity
- Introduction
- Characteristics of the oral cavity route
- Drug properties and the oral cavity
- Oral cavity dosage forms
- Counseling patients
- Selected reading
- 12 Oral delivery of immediate release dosage forma
- Introduction
- Characteristics of the gastrointestinal route
- Drug properties and the gastrointestinal route
- Immediate release dosage forms: oral liquids
- Immediate release dosage forms: oral solids
- Counseling patients
- Selected reading
- 13 Oral delivery of modified release solid dosage forms
- Introduction
- Characteristics of modified release oral solids.
- Drug properties that influence modified release dosage solids
- Dosage forms of modified release oral solids
- Counseling patients
- Selected reading
- 14 Rectal and vaginal drug delivery
- Introduction
- Characteristics of the rectal route
- Drug properties and the rectal route
- Characteristics of the vaginal route
- Drug properties and the vaginal route
- Dosage forms for the rectal and vaginal routes
- Quality evaluation and assurance
- Counseling patients
- Selected reading
- 15 Nasal drug delivery
- Introduction
- Characteristics of the nasal route
- Drug properties and the nasal route
- Dosage forms for the nasal route
- Counseling patients
- Selected reading
- 16 Drug delivery to the lung and from the lung
- Introduction
- Characteristics of the respiratory route
- Drug properties and the respiratory route
- Dosage forms for the respiratory route
- Counseling patients
- Selected reading
- 17 Drug delivery to the skin
- Introduction
- Characteristics of the dermal route
- Drug properties and the dermal route
- Dosage forms for the dermal route
- Counseling patients
- Selected reading
- 18 Transdermal dosage forms: Drug delivery to the blood stream
- Introduction
- Characteristics of the transdermal route
- Drug properties and the transdermal route
- Dosage forms for the transdermal route
- Counseling healthcare providers and patients
- Selected reading
- Appendix
- References
- Answers to questions and cases
- Chapter 1
- Chapter 2
- Chapter 3
- Chapter 4
- Chapter 5
- Chapter 6
- Chapter 7
- Chapter 8
- Chapter 9
- Chapter 10
- Chapter 11
- Chapter 12
- Chapter 13
- Chapter 14
- Chapter 15
- Chapter 16
- Chapter 17
- Chapter 18
- Index.