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Structure-based design of drugs and other bioactive molecules : tools and strategies /
In contrast to previous texts focusing on either computational, structural or synthetic methods, this one-of-a-kind guide integrates all three skill sets for a complete picture of contemporary structure-based design. As a result, this practical book demonstrates how to develop a high-affinity ligand...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Weinheim :
Wiley-VCH,
2014.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Ghosh, Arun K. | |
| 245 | 1 | 0 | |a Structure-based design of drugs and other bioactive molecules : |b tools and strategies / |c Arun K. Ghosh and Sandra Gemma. |
| 260 | |a Weinheim : |b Wiley-VCH, |c 2014. | ||
| 300 | |a 1 online resource (476 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 588 | 0 | |a Print version record. | |
| 504 | |a Includes bibliographical references at the end of each chapters and index. | ||
| 505 | 0 | |a Structure-based Design of Drugs and Other Bioactive Molecules: Tools and Strategies; Contents; Preface; 1 From Traditional Medicine to Modern Drugs: Historical Perspective of Structure-Based Drug Design; 1.1 Introduction; 1.2 Drug Discovery During 1928-1980; 1.3 The Beginning of Structure-Based Drug Design; 1.4 Conclusions; References; Part One: Concepts, Tools, Ligands, and Scaffolds for Structure-Based Design of Inhibitors; 2 Design of Inhibitors of Aspartic Acid Proteases; 2.1 Introduction; 2.2 Design of Peptidomimetic Inhibitors of Aspartic Acid Proteases. | |
| 505 | 8 | |a 2.8.4 Design of Acyl Guanidine-Based Inhibitors2.8.5 Design of Aminopyridine-Based Inhibitors; 2.8.6 Design of Aminoimidazole- and Aminohydantoin-Based Inhibitors; 2.9 Conclusions; References; 3 Design of Serine Protease Inhibitors; 3.1 Introduction; 3.2 Catalytic Mechanism of Serine Protease; 3.3 Types of Serine Protease Inhibitors; 3.4 Halomethyl Ketone-Based Inhibitors; 3.5 Diphenyl Phosphonate-Based Inhibitors; 3.6 Trifluoromethyl Ketone Based Inhibitors; 3.6.1 Synthesis of Trifluoromethyl Ketones; 3.7 Peptidyl Boronic Acid-Based Inhibitors. | |
| 520 | |a In contrast to previous texts focusing on either computational, structural or synthetic methods, this one-of-a-kind guide integrates all three skill sets for a complete picture of contemporary structure-based design. As a result, this practical book demonstrates how to develop a high-affinity ligand with drug-like properties for any given drug target for which a high-resolution structure exists. The authors, both of whom have successfully designed drug-like molecules that were later developed into marketed drugs, use numerous examples of recently developed drugs to present best practice in. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Drug development. | |
| 650 | 0 | |a Bioactive compounds. | |
| 650 | 0 | |a Biopolymers. | |
| 650 | 0 | |a Ligand binding (Biochemistry) | |
| 650 | 0 | |a Protease inhibitors. | |
| 650 | 0 | |a Drugs |x Structure-activity relationships. | |
| 650 | 0 | |a Drugs |x Design. | |
| 650 | 0 | |a Molecular structure. | |
| 650 | 0 | |a Structure-activity relationships (Biochemistry) | |
| 650 | 1 | 2 | |a Drug Design |
| 650 | 2 | 2 | |a Molecular Structure |
| 650 | 2 | 2 | |a Biopolymers |x chemistry |
| 650 | 2 | 2 | |a Protease Inhibitors |x chemistry |
| 650 | 2 | 2 | |a Structure-Activity Relationship |
| 650 | 2 | |a Biopolymers | |
| 650 | 6 | |a Médicaments |x Développement. | |
| 650 | 6 | |a Composés bioactifs. | |
| 650 | 6 | |a Biopolymères. | |
| 650 | 6 | |a Ligands (Biochimie) |x Fixation. | |
| 650 | 6 | |a Médicaments |x Relations structure-activité. | |
| 650 | 6 | |a Médicaments |x Conception. | |
| 650 | 6 | |a Structure moléculaire. | |
| 650 | 6 | |a Relations structure-activité (Biochimie) | |
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| 650 | 7 | |a Molecular structure |2 fast | |
| 650 | 7 | |a Drugs |x Design |2 fast | |
| 650 | 7 | |a Bioactive compounds |2 fast | |
| 650 | 7 | |a Biopolymers |2 fast | |
| 650 | 7 | |a Drug development |2 fast | |
| 650 | 7 | |a Drugs |x Structure-activity relationships |2 fast | |
| 650 | 7 | |a Ligand binding (Biochemistry) |2 fast | |
| 650 | 7 | |a Protease inhibitors |2 fast | |
| 700 | 1 | |a Gemma, Sandra. | |
| 758 | |i has work: |a Structure-based design of drugs and other bioactive molecules (Text) |1 https://id.oclc.org/worldcat/entity/E39PCGGt8GJ88mVmGhpqKcpQdP |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |a Ghosh, Arun K. |t Structure-based Design of Drugs and Other Bioactive Molecules. |d Hoboken : Wiley, 2014 |z 9783527333653 |
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