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Mucoadhesive Materials and Drug Delivery Systems.
Mucoadhesion defined as attachment of synthetic or natural materials to mucosal tissues has been widely exploited in pharmaceutical forms. This multi-author book provides an up-to-date account of current research on mucoadhesive materials and drug delivery systems. The introductory section describes...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken :
Wiley,
2014.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Mucoadhesive Materials and Drug Delivery Systems; Contents; About the Editor; List of Contributors; Preface; Section One: Structure and Physiology of Mucosal Surfaces in Relation to Drug Delivery; 1 Oral Mucosa: Physiological and Physicochemical Aspects; 1.1 Anatomical and Histological Aspects of Oral Cavity Tissues; 1.1.1 Tissue Architecture; 1.1.2 Innervation; 1.1.3 Receptors; 1.2 Production and Composition of Saliva; 1.2.1 Major Salivary Glands; 1.2.2 Minor Salivary Glands; 1.2.3 Saliva Composition; 1.2.4 Mucins; 1.2.5 Proline-rich Proteins; 1.2.6 Statherins; 1.2.7 Cystatins.
- 1.2.8 Histatins1.2.9 Salivary Amylase; 1.2.10 Diversity of Salivary Film; 1.3 Surface Architecture, Mechanical, Rheological and Transport Properties of Salivary Pellicle; 1.3.1 Ex Vivo Pellicle; 1.3.2 Saliva Collection and Handling; 1.3.3 Rheology; 1.3.4 Interfacial Rheology; 1.3.5 Adsorption and Surface Architecture; 1.3.6 Surface Forces; 1.3.7 Lubrication; 1.3.8 Transport Properties; 1.4 Future Perspective; References; 2 Anatomy of the Eye and the Role of Ocular Mucosa in Drug Delivery; 2.1 Introduction; 2.2 Anatomy of the Eye; 2.2.1 Outer Membranes; Conjunctiva, Cornea and Sclera.
- 2.2.2 Aqueous Chamber, Lens and Vitreous Body2.2.3 Choroid and Retina; 2.3 Introduction to Ocular Mucosa; 2.4 The Role of Ocular Mucosa in Drug Delivery; 2.5 Models for Ocular Drug Delivery; 2.6 Recent Advances in Topical Ocular Drug Delivery; 2.6.1 Improving Corneal Retention; 2.6.2 Other Topical Drug Delivery Options; 2.7 Conclusions; References; 3 Drug Delivery Across the Nasal Mucosa; 3.1 Introduction; 3.2 Drug Delivery via the Nasal Mucosa; 3.2.1 Drugs Administered for Local Action; 3.2.2 Drugs Administered for Systemic Effect; 3.2.3 Peptide and Protein Delivery.
- 3.3 Anatomy and Physiology of the Nasal Cavity3.3.1 Structure and Function of the Nasal Cavity; 3.3.2 Nasal Epithelia; 3.3.3 Airflow; 3.3.4 Nasal Secretions; 3.3.5 Mucociliary Clearance; 3.4 Disease States of the Nasal Cavity; 3.4.1 Disease States Altering Drug Absorption; 3.5 Transport Across the Membrane; 3.5.1 Transport Across the Nasal Membrane; 3.5.2 The Solute Carrier Family; 3.5.3 Other Nasal Mucosa Transporters; 3.5.4 Efflux; 3.5.5 Paracellular Transport; 3.6 Nose-to-Brain Drug Delivery; 3.7 Conclusion; References; 4 Gastrointestinal Mucosa and Mucus; 4.1 Introduction.
- 4.1.1 General Gastrointestinal Physiology4.2 The Gastrointestinal Mucus; 4.2.1 What is Mucus?; 4.2.2 Mucus Composition; 4.2.3 Anatomy of Goblet Cells and Mucin Biosynthesis; 4.2.4 Regulation of Mucus Secretion; 4.2.5 Mucus Functions; 4.2.6 Mucus Layer Structure: The Double-Layer Architecture; 4.2.7 Mucus Thickness; 4.2.8 Mucus Rheology; 4.2.9 Mucus Turnover; 4.2.10 Mucus and Ageing; 4.2.11 Mucus and Gastrointestinal Disease; 4.3 Conclusions; References; 5 Vaginal Mucosa and Drug Delivery; 5.1 Introduction; 5.2 Drug Delivery and the Human Vagina.