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Principles of toxicology : environmental and industrial applications /
A fully updated and expanded edition of the bestselling guide on toxicology and its practical applicationCovers the diverse chemical hazards encountered in the modern work and natural environment, and provides a practical understanding of these hazardsNew chapters cover the emerging areas of toxicol...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, New Jersey :
John Wiley and Sons, Inc.,
[2014]
|
| Edición: | Third edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Principles of toxicology : |b environmental and industrial applications / |c [edited by] Stephen M Roberts, Robert C James, Phillip L Williams. |
| 250 | |a Third edition. | ||
| 264 | 1 | |a Hoboken, New Jersey : |b John Wiley and Sons, Inc., |c [2014] | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 500 | |a Includes index. | ||
| 588 | 0 | |a Print version record and CIP data provided by publisher. | |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a A fully updated and expanded edition of the bestselling guide on toxicology and its practical applicationCovers the diverse chemical hazards encountered in the modern work and natural environment, and provides a practical understanding of these hazardsNew chapters cover the emerging areas of toxicology such as omics, computational toxicology, and nanotoxicologyProvides clear explanations and practical understanding of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystemsIncludes case histories and examples from industry demonstrate the application of toxicological principlesSupplemented with numerous illustrations to clarify and summarize key points, annotated bibliographies, and a comprehensive glossary of toxicological terms. | ||
| 505 | 0 | |a Title Page -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1 General Principles of Toxicology -- 1.1 BASIC DEFINITIONS AND TERMINOLOGY -- 1.2 TOXICOLOGY: A DIVERSE SCIENCE WITH TWO BASIC GOALS -- 1.3 HAZARD IDENTIFICATION FUNCTION -- 1.4 DOSE-RESPONSE/RISK ASSESSMENT FUNCTION -- Defining Dose and Response -- Dose-Response Graphs -- 1.5 HOW DOSE-RESPONSE DATA CAN BE USED -- 1.6 AVOIDING INCORRECT CONCLUSIONS FROM DOSE-RESPONSE AND HAZARD IDENTIFICATION DATA -- Species-Related Differences in Hazard and Dose-Response Information: A Frequent Problem that Raises Uncertainty for Animal-to-Human Extrapolations -- 1.7 ADDITIONAL FACTORS INFLUENCING HAZARD IDENTIFICATION AND DOSE-RESPONSE DATA -- Route of Exposure -- Sex -- Age -- Effects of Chemical Interaction (Synergism, Potentiation, and Antagonism) -- Modes of Chemical Interaction -- Genetic Makeup -- Health Status -- Chemical-Specific Factors -- 1.8 DESCRIPTIVE TOXICOLOGY: TESTING ADVERSE EFFECTS OF CHEMICALS AND GENERATING DOSE-RESPONSE DATA -- 1.9 EVIDENCE-BASED TOXICOLOGY -- 1.10 SUMMARY -- SUGGESTED READING -- Chapter 2 Xenobiotic Absorption, Distribution, Metabolism, and Excretion -- 2.1 XENOBIOTIC INTERACTIONS WITH THE BIOLOGICAL (CELL) MEMBRANE -- Membrane Structure -- Ionization of Xenobiotics -- 2.2 ABSORPTION -- Gastrointestinal Tract -- Lungs -- Skin -- 2.3 DISTRIBUTION -- Overview -- Albumin Binding -- 2.4 Metabolism -- Overview -- Metabolism Enzymes and Reactions -- Xenobiotic-Metabolizing Enzyme Induction -- 2.5 EXCRETION (ELIMINATION) -- Renal -- Biliary Excretion -- Respiration -- Milk -- 2.6 SUMMARY -- SUGGESTED READING -- Chapter 3 Toxicokinetics -- 3.1 INTRODUCTION -- Absorption, Distribution, Metabolism, and Elimination -- Toxicokinetic Modeling -- 3.2 TOXICOKINETIC MODELING FUNDAMENTALS -- Kinetic Processes -- Compartmental Analysis -- Clearance Modeling. | |
| 505 | 8 | |a PBPK Modeling -- 3.3 APPLICATIONS OF TOXICOKINETICS -- Risk Assessment -- Chemical-Specific Adjustment Factors -- Interindividual Variability -- 3.4 CASE STUDY: TOXICOKINETICS OF DIBUTYL PHTHALATE -- Design of Kinetic Studies -- Analysis of Kinetic Studies -- Development of a PBPK Model -- Model Parameterization -- Model Validation -- Application of PBPK Model -- 3.5 TOXICOKINETICS IN THE FUTURE -- Interpretation of Human Biomonitoring Data -- Quantitative In Vitro to In Vivo Extrapolation -- Modeling of Pharmacodynamics -- 3.6 SUMMARY -- REFERENCES AND SUGGESTED READING -- Chapter 4 Omics Technologies in Toxicology -- 4.1 INTRODUCTION TO OMICS -- How Omics Came to Be -- 4.2 GENOMICS -- Change in Semantics for Microarrays -- Printing of Microarrays -- Preparing Target Molecules -- Hybridization of Microarrays -- Data Analysis for Gene Expression Microarrays -- Microarray Platforms -- MicroRNA Expression Profiling -- 4.3 PROTEOMICS -- 4.4 METABOLOMICS -- 4.5 PHARMACOGENOMICS -- 4.6 SYSTEMS BIOLOGY -- Trends in Data Analysis -- 4.7 SUMMARY -- SUGGESTED READING -- Chapter 5 Toxicity of the Hematopoietic System -- 5.1 HEMATOPOIESIS: ORIGINS OF HEMATOPOIETIC CELLS -- Myelopoiesis -- Erythropoiesis -- Thrombopoiesis -- Granulopoiesis -- Monopoiesis -- Lymphopoiesis -- 5.2 HEMATOTOXICITY: ASSAYS USED FOR ANALYSIS -- Complete Blood Count -- Peripheral Blood Smear -- Bone Marrow Aspirate and Biopsy -- Flow Cytometry/Immunophenotyping -- Chromosome Analysis -- Colony-Forming Units Assay -- 5.3 DISEASES OF THE HEMATOPOIETIC SYSTEM -- Anemia -- Neutropenia and Agranulocytosis -- Thrombocytopenia -- Aplastic Anemia -- Myeloproliferative Neoplasms -- Myelodysplastic/Myeloproliferative Neoplasms -- Myelodysplastic Syndromes -- Acute Myeloid Leukemia -- 5.4 HEMATOTOXINS: KNOWN HEMATOTOXIC AGENTS -- REFERENCES AND SUGGESTED READING. | |
| 505 | 8 | |a Chapter 6 Hepatotoxicity: Toxic Effects on the Liver -- 6.1 PHYSIOLOGICAL AND MORPHOLOGICAL BASES OF LIVER INJURY -- Physiological Considerations -- Morphological Consideration -- 6.2 TYPES OF LIVER INJURY -- Hepatocellular Degeneration and Death -- Fatty Liver -- Cholestasis -- Vascular Injury -- Cirrhosis -- Tumors -- 6.3 EVALUATION OF LIVER INJURY -- Symptoms of Liver Toxicity -- Morphological Evaluation -- Blood Tests -- 6.4 SUMMARY -- REFERENCES AND SUGGESTED READING -- Chapter 7 Nephrotoxicity: Toxic Responses of the Kidney -- 7.1 RENAL STRUCTURE AND PHYSIOLOGY -- Overview of Kidney Structure and Function -- Nephron Structure and Heterogeneity -- Countercurrent Flow and Urinary Concentration Mechanism -- Membrane Transport Processes -- Summary of Physiological Factors Contributing to the Kidneys as a Target Organ for Toxic Chemicals -- 7.2 CLASSIFICATIONS OF RENAL INJURY -- Acute Kidney Injury -- Chronic Kidney Injury -- Responses at the Cellular Level -- 7.3 ASSESSMENT OF RENAL FUNCTION AND INJURY IN THE CLINIC AND IN IN VIVO ANIMAL MODELS -- Measurement of GFR -- Basic Urinalysis -- Secretion of Enzymes and Other Proteins into Urine as Biomarkers of Renal Injury and Site and Mechanism of Action -- 7.4 IN VITRO MODELS TO STUDY RENAL FUNCTION AND INJURY -- Isolated Perfused Kidney -- Renal Slices -- Isolated Tubules and Tubular Fragments -- Suspensions of Isolated Renal Cells and Primary Cell Culture -- Immortalized Cell Lines -- 7.5 EXAMPLES OF ENVIRONMENTAL, INDUSTRIAL, AND THERAPEUTIC CHEMICALS THAT PRODUCE NEPHROTOXICITY -- Halogenated Solvents: Tri- and Perchloroethylene -- Heavy Metals: Mercury and Cadmium -- Analgesics: Acetaminophen -- Antibiotics: Cephalosporins -- Antineoplastics: Cisplatin -- 7.6 SUMMARY -- SUGGESTED READING -- Chapter 8 Neurotoxicity: Toxic Effects on the Nervous System -- 8.1 Nervous System. | |
| 505 | 8 | |a Central Nervous System -- Peripheral Nervous System -- Neurons -- Glia -- Blood-Brain Barrier -- 8.2 Neurotoxicological Agents -- 8.3 Neurotoxicants that Induce Neuronopathy -- 8.4 Neurotoxicants that Induce Axonopathy -- 8.5 Neurotoxicants that Induce Myelinopathy -- 8.6 Neurotoxicants that Induce Alterations of Neurotransmission at the Synapse -- 8.7 Role for Glia in Neurotoxicity -- 8.8 Evaluation of Neurotoxic Injury -- 8.9 Summary -- Suggested Reading -- Chapter 9 Dermatotoxicity: Toxic Effects on the Skin -- 9.1 HISTOLOGY -- 9.2 FUNCTIONS -- 9.3 TYPES OF DERMAL TOXICITY -- Irritant Dermatitis -- Allergic Contact Dermatitis -- Systemic Contact Dermatitis -- Photosensitivity (Photoirritation and Photoallergic Contact Dermatitis) -- Contact Urticaria Syndrome (Nonimmunological [NICU] and Immunological [ICU]) -- Toxic Epidermal Necrolysis -- Acneiform Dermatoses -- Pigment Disturbances -- Skin Cancer -- 9.4 SUMMARY -- SUGGESTED READING -- Chapter 10 Pulmonotoxicity: Toxic Effects in the Lung -- 10.1 ANATOMY AND PHYSIOLOGY OF RESPIRATORY SYSTEM -- Respiratory Tract -- Lung -- 10.2 GENERAL PRINCIPLES OF INHALATION TOXICOLOGY -- Gases -- H2S -- Other Respiratory Irritants -- Particles -- Particle Size -- Particle Deposition -- Particle Clearance -- 10.3 ACUTE RESPONSES OF THE RESPIRATORY SYSTEM TO INJURY -- Burden of Oxidative Stress in Response to Respiratory Injury -- Immune Reactivity in Response to Respiratory Injury -- Alteration of Airway Function -- Acute Pulmonary Edema -- 10.4 CHRONIC RESPONSE OF THE RESPIRATORY SYSTEM TO INJURY -- Chronic Obstructive Pulmonary Disease -- Fibrosis -- Asthma -- Silicosis -- Lung Cancer -- Other Lung Diseases -- 10.5 EVALUATION OF TOXIC DAMAGE IN THE RESPIRATORY SYSTEM -- Studies in Humans -- Studies in Animals -- Animal Exposure -- Pulmonary Function Test -- Lung Lavage Assay -- Lung Perfusion. | |
| 505 | 8 | |a Fixation Technique for Morphological Study -- In vitro Approaches for Both Human and Animal Study -- Morphologic Techniques -- Microdissection -- Cell Culture -- 10.6 SUMMARY -- REFERENCES AND SUGGESTED READING -- Chapter 11 Immunotoxicity: Toxic Effects on the Immune System -- 11.1 BIOLOGY OF THE IMMUNE RESPONSE -- 11.2 TYPES OF IMMUNE REACTIONS AND DISORDERS -- Allergic Reactions -- Immunosuppression and Immune Enhancement -- Autoimmunity -- 11.3 CLINICAL TESTS FOR DETECTING IMMUNOTOXICITY -- Immunoglobulin Concentrations -- T- and B-Cell Concentrations -- Cutaneous Anergy -- In Vitro Tests -- Fluorescent Antinuclear Antibody Assay -- 11.4 TESTS FOR DETECTING IMMUNOTOXICITY IN ANIMAL MODELS -- 11.5 SPECIFIC CHEMICALS THAT ADVERSELY AFFECT THE IMMUNE SYSTEM -- Metals -- Polychlorinated Dibenzo(p)dioxins -- Dust and Particulates -- Pesticides -- Solvents -- Miscellaneous Agents -- 11.6 SUMMARY -- SUGGESTED READING -- Chapter 12 Toxic Effects on Reproduction -- 12.1 GENERAL PHYSIOLOGY OF THE MALE AND FEMALE REPRODUCTIVE SYSTEM -- The Male Reproductive System -- The Female Reproductive System -- 12.2 GENERAL METHODS TO ANALYZE REPRODUCTIVE TOXICANTS -- The Mammary Gland -- New Technologies to Assess Reproductive Toxicants -- 12.3 REPRODUCTIVE TOXICANTS -- Male Reproductive Toxicants -- Female Reproductive Toxicants -- REFERENCES AND SUGGESTED READING -- Chapter 13 Developmental Toxicology -- 13.1 BIRTH AND DEVELOPMENTAL ANOMALIES: TERATOLOGY -- The Principles of Teratology -- Birth Defect Prevalence -- 13.2 PHYSIOLOGY OF PREGNANCY -- Maternal Cardiovascular System -- Metabolism in the Prospective Mother -- Metabolism in the Fetus -- Metabolism in the Placenta -- Maternal Respiration -- Maternal Renal Function -- Summary of Pregnancy Physiology -- 13.3 WORKPLACE, OCCUPATION, AND ADVERSE REPRODUCTIVE EFFECTS -- Nursing/Health Care Workers. | |
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Toxicology. | |
| 650 | 0 | |a Industrial toxicology. | |
| 650 | 0 | |a Environmental toxicology. | |
| 650 | 2 | |a Toxicology | |
| 650 | 2 | |a Ecotoxicology | |
| 650 | 6 | |a Toxicologie. | |
| 650 | 6 | |a Toxicologie industrielle. | |
| 650 | 6 | |a Écotoxicologie. | |
| 650 | 7 | |a toxicology. |2 aat | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a Environmental toxicology |2 fast | |
| 650 | 7 | |a Industrial toxicology |2 fast | |
| 650 | 7 | |a Toxicology |2 fast | |
| 700 | 1 | |a Williams, Phillip L., |d 1952- | |
| 700 | 1 | |a James, Robert C. | |
| 700 | 1 | |a Roberts, Stephen M., |d 1950- | |
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| 776 | 0 | 8 | |i Print version: |t Principles of toxicology. |b Third edition. |d Hoboken, New Jersey : John Wiley and Sons, Inc., [2014] |z 9780470907917 |w (DLC) 2014020557 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=1889220 |z Texto completo |
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