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Neuroscience for Neurologists.
The last decade has seen major advances in our understanding of the basic scientific principles that underpin clinical neurology. Many of these advances have already had a major impact on routine clinical practice, and this is likely to continue in the future. Although this makes it an exciting time...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Singapore :
World Scientific Publishing Company,
2006.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Chinnery, Patrick F. | |
| 245 | 1 | 0 | |a Neuroscience for Neurologists. |
| 260 | |a Singapore : |b World Scientific Publishing Company, |c 2006. | ||
| 300 | |a 1 online resource (468 pages) | ||
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| 520 | |a The last decade has seen major advances in our understanding of the basic scientific principles that underpin clinical neurology. Many of these advances have already had a major impact on routine clinical practice, and this is likely to continue in the future. Although this makes it an exciting time to practice neurology, it also presents new challenges. How can established general neurologists keep up-to-date with clinically relevant scientific advances, and how can the specialist remain competent outside his own field? What should trainee neurologists learn to prepare themselves for the futu. | ||
| 505 | 0 | |a 1. Neurogenetics-single gene disorders. Genetic linkage analysis. Linkage disequilibrium and association. Mutational spectrum. Molecular genetic tools. Molecular genetic testing. Animal models. Web-based information for genetic diagnosis and testing.Outlook. Acknowledgements. References -- 2. Neurogenetics II: complex disorders. Guiding principles. Applications to clinical neurology. Tauopathies. New technologies. Conclusions. Appendix A. Human genetic variation. Appendix B. Genetic linkage and association analyses. References -- 3. Functional genomics and proteomics: application in neurosciences. Functional genomics. RNA preparation. Differential display. SAGE. Microarrays. Real time Q-PCR. Proteomics. Two dimensional gel electrophoresis. ICAT-isotope coded affinity tags. Protein microarrays. Mass spectrometry. SELDI. Future prospects. Acknowledgements. References -- 4. Mitochondria. Historical introduction. What are mitochondria and what do they do? The genetic basis of mitochondrial biogenesis. Mitochondrial disease: genotype and phenotype. Mitochondrial genetic factors. Confirming suspected mitochondrial disease. Managing mitochondrial disease- the future. Animal models. Conclusion. Acknowledgements. References -- 5. Nanotechnology for neuronal ion channels. Channels-essential for neuronal excitability. History of the voltage clamp technique. Application to clinical neurology. Principles behind the techniques. Potential application of the technologies in the future. Conclusions. Acknowledgements. Appendix 1. Glossary of terms. Appendix 2. Associated websites of interest. References -- 6. Molecular and cellular pathways of neurodegeneration in motor neurone disease. What do we know about the causes of motor neurone degeneration? Genetics of ALS/MND. Oxidative stress. Excitotoxicity. Mitochondrial dysfunction. Cytoskeletal elements and axonal transport. Protein aggregation. Inflammatory cascades and the role of non-neuronal cells. Apoptosis. Cell specific features of motor neurones which may predispose to neurodegeneration. Conclusions. Acknowledgements. References -- 7. Neurodegenerative disorders: Parkinson's disease and Huntington's disease. Parkinson's disease. Huntington's disease. Conclusions. References -- 8. Molecular pathogenesis of neuroinflammation. A brief history of immune privilege. Experimental autoimmune encephalomyelitis-an animal model to study interactions of the immune system with the CNS. How modern techniques contributed to our understanding of neuroinflammation in EAE and multiple sclerosis. Microdissection and molecular analyses of single cells involved in the disease process. Novel techniques and their contribution to clinical neurology-a future perspective. Conclusion. Acknowledgements. References -- 9. Neurovirology. Introduction. Specific techniques and their applications. Acknowledgements. References -- 10. Molecular neurology of prion disease. Introduction to prions and historical perspective. Molecular biology of prions. Application to clinical neurology. References -- 11. Monitoring and interpretation of intracranial pressure. Methods of measurement. Typical events and trends in ICP monitoring. Waveform analysis of ICP. Pressure-volume compensatory reserve. Cerebrovascular pressure reactivity. Other methods of ICP analysis. Practical use of the ICP derived parameters: "optimal CPP" and multiple trend analysis. Association with outcome following severe head injury. ICP in hydrocephalus and benign intracranial hypertension. Attempts to measure ICP and CPP non-invasively. Is ICP monitoring useful. Acknowledgements. References -- 12. Cerebral perfusion and stroke. Cerebrovascular anatomy. Methods for measurement of cerebral blood flow. Regulation of the normal cerebral circulation. Cerebral circulation responses to focal ischaemia. The ischaemic penumbra. Mechanisms of infarction in penumbral tissue. Summary. References -- 13. A review of structural magnetic resonance neuroimaging. Definition(s) of structural MRI. Applications of structural MRI. The next ten years. Conclusion. Acknowledgements. References -- 14. Applications of positron emission tomography (PET) in neurology. Principles of PET. Application of PET to clinical neurology. Potential future applications. References -- 15. Functional magnetic resonance imaging. Principles of functional MRI. Clinical applications of fMRI. fMRI as a marker of pathological state. Linking fMRI to other MRI techniques for characterising pathology and other directions for the future. Acknowledgements. References -- 16. How to spot bias and other potential problems in randomised controlled trials. Bias. Precision. Analysis and inferences. The future. Conclusions. Acknowledgements. References. | |
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Neurosciences. | |
| 650 | 0 | |a Neurology. | |
| 650 | 2 | |a Neurosciences | |
| 650 | 2 | |a Neurology | |
| 650 | 6 | |a Neurosciences. | |
| 650 | 6 | |a Neurologie. | |
| 650 | 7 | |a Neurology |2 fast | |
| 650 | 7 | |a Neurosciences |2 fast | |
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