Ex-vivo and In-vivo Optical Molecular Pathology.

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The result of a unique collaboration between clinicians and physicists, this book provides an unparalleled overview of a new generation of diagnostic tools in clinical pathology. The introductory three chapters cover the present status and limitations of currently used methods, followed by an outlin...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Popp, Jürgen
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken : Wiley, 2014.
Temas:
Pathology, Molecular.
Physiology, Pathological > Animal models.
Spectrum analysis.
Pathology, Molecular
Pathologie moléculaire.
Physiopathologie > Modèles animaux.
Physiology, Pathological > Animal models
Spectrum analysis
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Ex-vivo and In-vivo Optical Molecular Pathology; Contents; List of Contributors; Preface; Chapter 1 Clinical Pathology; 1.1 Introduction; 1.2 Pathology as a Medical and Research Discipline; 1.3 Historical Perspectives; 1.4 Specimens; 1.4.1 Biopsies, Resections, and Cytology; 1.5 Conventional Diagnostic Methods in Pathology; 1.5.1 Cytology; 1.5.2 Histology; 1.5.3 Microscopy; 1.5.4 Intraoperative Assessment (Frozen Section Examination); 1.5.5 Why Pathologists Do Not Like Frozen Tissue Examination?; 1.5.6 Microdissection.
  • 1.6 Nonconventional (Ancillary) Diagnostic Methods in Pathology (Molecular Assessment of Tissues)1.6.1 In Situ Reactions; 1.6.1.1 Immunofluorescence (IF); 1.6.1.2 Immunohistochemistry (IHC); 1.6.1.3 Fluorescent In Situ Hybridization (FISH); 1.6.2 Non-In Situ Methods; 1.7 Summary of Major Terms in Clinical Pathology; 1.7.1 Injury and Adaptation; 1.7.2 Inflammation and Repair; 1.7.3 Neoplastic Diseases; 1.8 Limitations of Clinical and Diagnostic Pathology; 1.8.1 Prediction of Tumor Behavior; 1.8.2 Diagnosis of Tumor Origin in a Case with Metastatic Tumor Disease.
  • 1.8.3 Individualized Medicine and Targeted TherapyFurther Readings; Chapter 2 Clinical Endoscopy in Gastrointestinal Diseases; 2.1 Introduction; 2.2 White-Light Endoscopy; 2.3 Chromoendoscopy; 2.4 Virtual Chromoendoscopy; 2.5 Endomicroscopy and Endocytoscopy; 2.6 Endoscopic Spectroscopy; 2.6.1 Autofluorescence Imaging; 2.6.2 Raman Spectroscopy; 2.7 Perspectives and Conclusions; References; Chapter 3 Molecular Pathology via Infrared and Raman Spectral Imaging; 3.1 Introduction; 3.2 Background; 3.3 Methods; 3.3.1 Sample Preparation; 3.3.2 Collection of Hyperspectral Data Cubes.
  • 3.3.3 Data Preprocessing3.3.4 Presorting (Cluster Analysis); 3.3.5 Visual Imaging; 3.3.6 Annotation; 3.3.7 Diagnostic Data Analysis; 3.3.8 Visual Data Analysis: Factor Methods; 3.4 Results and Discussion; 3.4.1 IR-SHP: Detection of Metastases and Micro-Metastases in Lymph Nodes; 3.4.1.1 IR-SHP of Micro-Metastases in Lymph Nodes; 3.4.1.2 IR-SHP of Lymphocyte Activation in Lymph Nodes; 3.4.2 SHP of Squamous Cell Carcinoma and Adenocarcinomas; 3.4.2.1 Distinction of Different Cancer Types by IR-SHP; 3.4.2.2 Diagnosis of Lung SqCC and Lung ADC via IR-SHP.
  • 3.4.2.3 Diagnosis of Cervical SqCC and Cervical ADC via SHP3.4.3 Results from Infrared Spectral Cytopathology (SCP); 3.4.3.1 Background; 3.4.3.2 Design and Methods of the Preclinical Trial for Oral Screening; 3.4.3.3 SCP Results for the Oral Mucosa; 3.4.3.4 SCP Results for the Cervical Mucosa; 3.4.4 IR and Raman-SHP of Brain Metastases; 3.4.4.1 IR and Raman Spectra of Brain Tissue; 3.4.4.2 Identification of Tumor Margins; 3.4.4.3 Determination of Primary Tumor; 3.4.5 Raman-SCP of Circulating Tumor Cells; 3.4.5.1 Dried Cells; 3.4.5.2 Tweezed Cells in Buffer.

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