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Peptidomimetics in Organic and Medicinal Chemistry.
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics i...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken :
Wiley,
2014.
©2014 |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 020 | |a 9781119950608 | ||
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| 049 | |a UAMI | ||
| 100 | 1 | |a Guarna, Antonio. | |
| 245 | 1 | 0 | |a Peptidomimetics in Organic and Medicinal Chemistry. |
| 260 | |a Hoboken : |b Wiley, |c 2014. | ||
| 264 | 4 | |c ©2014 | |
| 300 | |a 1 online resource (320 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 588 | 0 | |a Print version record. | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Cover; Title Page; Copyright; Contents; Preface; Abbreviations; Part I The Basics of Peptidomimetics; Chapter 1 The Basics of Peptidomimetics; 1.1 Introduction; 1.2 Definition and Classification; 1.3 Strategic Approaches to Peptidomimetic Design; 1.3.1 Modification of Amino Acids; 1.3.2 Compounds with Global Restrictions; 1.3.3 Molecular Scaffolds Mimicking the Peptidic Backbone; 1.4 Successful Examples of Peptidomimetic Drugs; 1.4.1 ACE Inhibitors; 1.4.2 Thrombin Inhibitors; 1.5 Conclusion; References; Chapter 2 Synthetic Approaches towards Peptidomimetic Design; 2.1 Introduction | |
| 505 | 8 | |a 2.2 Local Modifications2.2.1 Single Amino Acid Modifications; 2.2.2 Dipeptide Isosteres; 2.2.3 Retro-inverso Peptides; 2.2.4 N-Methylation of Peptides; 2.2.5 Azapeptides; 2.2.6 Peptoids; 2.3 Global Restrictions through Cyclic Peptidomimetics; 2.4 Peptidomimetic Scaffolds; 2.5 Conclusions; References; Part II Synthetic Methods and Molecules; Chapter 3 Peptidomimetic Bioisosteres; 3.1 Introduction; 3.2 Peptide Bond Isosteres; 3.2.1 Thioamides; 3.2.2 Esters; 3.2.3 Alkenes and Fluoroalkenes; 3.2.4 Transition-State Isosteres; 3.3 Side-Chain Isosteres | |
| 505 | 8 | |a Chapter 5 Click Chemistry: The Triazole Ring as a Privileged Peptidomimetic Scaffold5.1 Introduction; 5.1.1 CuAAC Reaction; 5.1.2 Triazole Ring as a Peptidomimetic Isostere; 5.2 Triazole-Containing Peptidomimetics Elaborated through `Click Chemistry'; 5.2.1 Macrocycles; 5.2.2 Oligomers and Foldamers; 5.3 Relevant Applications in Drug Discovery; 5.3.1 AChE Inhibitors; 5.3.2 HIV Protease Inhibitors; 5.3.3 MMP Inhibitors; 5.3.4 Integrin Ligands; 5.4 Conclusions; Acknowledgements; References; Chapter 6 Peptoids; 6.1 Introduction and Basics of Peptoids; 6.2 Synthetic Methods | |
| 520 | |a A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chai. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Peptide drugs. | |
| 650 | 0 | |a Proteins |x Therapeutic use. | |
| 650 | 0 | |a Drugs |x Design. | |
| 650 | 1 | 2 | |a Drug Design |
| 650 | 1 | 2 | |a Peptidomimetics |x therapeutic use |
| 650 | 2 | 2 | |a Peptidomimetics |x metabolism |
| 650 | 6 | |a Médicaments peptidiques. | |
| 650 | 6 | |a Protéines |x Emploi en thérapeutique. | |
| 650 | 6 | |a Médicaments |x Conception. | |
| 650 | 7 | |a Drugs |x Design |2 fast | |
| 650 | 7 | |a Peptide drugs |2 fast | |
| 650 | 7 | |a Proteins |x Therapeutic use |2 fast | |
| 700 | 1 | |a Trabocchi, Andrea. | |
| 758 | |i has work: |a Peptidomimetics in organic and medicinal chemistry (Text) |1 https://id.oclc.org/worldcat/entity/E39PCH3vcHmtjCJphphPpqCB4C |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |a Guarna, Antonio. |t Peptidomimetics in Organic and Medicinal Chemistry. |d Hoboken : Wiley, ©2014 |z 9781119950608 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=1653576 |z Texto completo |
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