The Biostatistics of Aging : From Gompertzian Mortality to an Index of Aging-Relatedness.

A practical and clarifying approach to aging and aging-related diseases Providing a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtlenotion-with consequential biomedical and public h...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Levy, Gilberto
Otros Autores: Levin, Bruce
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken : Wiley, 2014.
Temas:
Aging > Statistical methods.
Mortality > Statistical methods.
Life spans (Biology)
Life expectancy.
Mortality.
Aging > pathology
Epidemiologic Methods
Life Expectancy
Models, Statistical
Mortality
Vieillissement > Méthodes statistiques.
Mortalité > Méthodes statistiques.
Durée de vie (Biologie)
Espérance de vie.
Mortalité.
mortality.
Life expectancy
Aging > Statistical methods
Mortality > Statistical methods
Acceso en línea:Texto completo
Tabla de Contenidos:
  • THE BIOSTATISTICS OF AGING: From Gompertzian Mortalitytoan Index of Aging-Relatedness; Copyright; CONTENTS; PREFACE AND ACKNOWLEDGMENT; 1 Introduction; 2 An Account of Gompertzian Mortality through Statisticaland Evolutionary Arguments; 2.1 The Statistical Theory of Extreme Values; 2.1.1 Background to Results; 2.1.2 Original Results; 2.2 The Evolutionary Theory of Aging; 2.2.1 The Argument for Gompertzian Mortality; 2.2.2 Boundaries of the Argument; 3 The Argument against Gompertzian Mortality; 3.1 Departures from the Gompertz Model; 3.2 An Evolution-Based Model of Causation.
  • 4 The Index of Aging-Relatedness4.1 A Survival Mixture Model of the Gompertz and WeibullDistributions; 4.2 Definition and Interpretation of the Index of Aging-Relatedness; 4.3 The Survival Mixture Model and Competing Risks; 4.4 Estimation of the Model Parameters; 4.5 Illustrative Application: The Israeli Ischemic Heart Disease Study; 4.6 Precision of Estimation; 5 Discussion: Implications; 5.1 The Meaning of the Gompertz Parameter; 5.2 Age as a Risk Factor for Disease; 5.3 Are Aging-Related Diseases an Integral Part of Aging?; 5.4 Biological versus Chronological Aging.
  • 5.5 The Public Health Notion of Compression of Morbidity5.6 A Picture of Aging for the Twenty-First Century; APPENDIX A: PROOFS OF RESULTS IN SECTION 2.1.2 WITHSOME EXTENSIONS; APPENDIX B: DERIVATION OF HAMILTON'S EQUATIONFOR THE FORCE OF NATURAL SELECTIONON MORTALITY; APPENDIX C: SOME PROPERTIES OF THE GOMPERTZ ANDWEIBULL DISTRIBUTIONS; APPENDIX D: FIRST AND SECOND PARTIAL DERIVATIVES OFTHE MIXTURE LOG-LIKELIHOOD FUNCTION; APPENDIX E: EXPECTATION-CONDITIONAL MAXIMIZATION(ECM) ALGORITHM; APPENDIX F: R PROGRAM; REFERENCES; AUTHOR INDEX; SUBJECT INDEX.

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