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20240329122006.0 |
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131230s2014 enk ob 001 0 eng |
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|a 9781118494028
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|2 23
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|a UAMI
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| 245 |
0 |
0 |
|a Antiplatelet therapy in cardiovascular disease /
|c edited by Ron Waksman, Paul A. Gurbel, Michael A. Gaglia, Jr.
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| 264 |
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1 |
|a Chichester, West Sussex :
|b Wiley-Blackwell,
|c 2014.
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| 300 |
|
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|a 1 online resource
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 504 |
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|a Includes bibliographical references and index.
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| 588 |
0 |
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|a Print version record and CIP data provided by publisher.
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0 |
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|a Antiplatelet Therapy in Cardiovascular Disease; Copyright; Contents; List of Contributors; Foreword; Preface; Section I Platelet Biology and Pathophysiology; 1 Platelet Pathophysiology and its Role in Thrombosis; Role of platelets during initiation of atherosclerosis and plaque formation; Role of platelets in thrombosis; References; 2 Platelet Receptors and Drug Targets: COX-1; Structure, expression, and catalytic activity of platelet COX-1; Functional role of platelet COX -1; Genetic polymorphisms of COX-1 and COX-2 expression in platelets.
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| 505 |
8 |
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|a Platelet COX-1 as a target for antithrombotic therapyInteraction between aspirin and naNSAIDs at the level of platelet COX-1; In vitro and in vivo evidence for aspirin/naNSAID interaction; Concluding remarks; References; 3 Platelet Receptors and Drug Targets: P2Y12; P2 receptors; Roles of adenine nucleotides in platelet function; P2Y12; Conclusions; References; 4 Platelet Receptors and Drug Targets: GP IIb/IIIa; Introduction; Biology of the receptor; Glycoprotein IIb/IIIa receptor in platelet physiology; Platelet aggregation phase; "Inside-out" and "outside-in" GPIIb/IIIa signaling phenomenon.
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| 505 |
8 |
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|a Glycoprotein IIb/IIIa receptor and thrombus formationGlycoprotein IIb/IIIa receptor antagonists; Intravenous versus oral preparations: clinical aspects; Acknowledgment; References; 5 Platelet Receptors and Drug Targets: PAR1, Collagen, vWF, Thromboxane, and Other Novel Targets; Introduction; Protease-activated receptor 1 (PAR1); References; 6 Role of Inflammation and Hypercoagulability in Thrombosis; References; Section II Platelet Function Tests; 7 Light Transmission Aggregometry; Technique; References; 8 Vasodilator-Stimulated Phosphoprotein (VASP) Assay; Introduction; The VASP index assay.
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| 505 |
8 |
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|a VASP index and clinical eventsAlteration of antiplatelet therapy based on the VASP index; VASP index and new oral antiplatelet agents; Conclusions; References; 9 VerifyNow P2Y12 and Plateletworks Assays; Introduction; Verifynow P2Y12; Plateletworks; Validity of the test in measuring antiplatelet effect and its association with clinical outcomes; Conclusion; References; 10 Multiplate Analyzer; Historical background; Principles of the Multiplate® analyzer; Advantages; Disadvantages; Clinical studies in cardiovascular medicine; Studies in cardiovascular surgery.
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| 505 |
8 |
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|a Consensus definitions and cutoff values concerning platelet reactivitySummary; Acknowledgment; References; 11 Shear Stress-Based Platelet Function Tests; PFA-100; IMPACT-R; References; 12 Thrombelastography and Other Novel Techniques; Novel techniques; T2 magnetic resonance (T2MR); Shear-induced platelet aggregation assays; References; Section III Antiplatelet pharmacology; 13 Aspirin; Mode of antiplatelet action; Time dependency of inhibition of platelet function by aspirin; Dose-dependent inhibition of platelet function by aspirin; Negative interactions with other drugs.
|
| 590 |
|
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
|
| 650 |
|
0 |
|a Cardiovascular system
|x Diseases
|x Chemotherapy.
|
| 650 |
|
0 |
|a Anticoagulants (Medicine)
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| 650 |
1 |
2 |
|a Cardiovascular Agents
|x therapeutic use
|
| 650 |
1 |
2 |
|a Platelet Aggregation Inhibitors
|x therapeutic use
|
| 650 |
|
2 |
|a Anticoagulants
|
| 650 |
2 |
2 |
|a Cardiovascular Diseases
|x blood
|
| 650 |
2 |
2 |
|a Cardiovascular Diseases
|x drug therapy
|
| 650 |
2 |
2 |
|a Platelet Function Tests
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| 650 |
|
6 |
|a Appareil cardiovasculaire
|x Maladies
|x Chimiothérapie.
|
| 650 |
|
6 |
|a Anticoagulants.
|
| 650 |
|
7 |
|a HEALTH & FITNESS
|x Diseases
|x General.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Clinical Medicine.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Diseases.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Evidence-Based Medicine.
|2 bisacsh
|
| 650 |
|
7 |
|a MEDICAL
|x Internal Medicine.
|2 bisacsh
|
| 650 |
|
7 |
|a Anticoagulants (Medicine)
|2 fast
|
| 650 |
|
7 |
|a Cardiovascular system
|x Diseases
|x Chemotherapy
|2 fast
|
| 655 |
|
4 |
|a Internet Resources.
|
| 700 |
1 |
|
|a Waksman, Ron,
|e editor.
|
| 700 |
1 |
|
|a Gurbel, Paul A.,
|e editor.
|
| 700 |
1 |
|
|a Gaglia, Michael A.,
|c Jr,
|e editor.
|
| 758 |
|
|
|i has work:
|a Antiplatelet therapy in cardiovascular disease (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCGPYJc4RC8tgX4jw33YqXq
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
| 776 |
0 |
8 |
|i Print version:
|t Antiplatelet therapy in cardiovascular disease.
|d Chichester, West Sussex : John Wiley & Sons, 2014
|z 9781118275757
|w (DLC) 2013049556
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=1652083
|z Texto completo
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