Understanding and exploiting protein-protein interactions as drug targets /

The ten chapters of this book provide an understanding of the key aspects in targeting PPIs with synthetic agents in a concise yet comprehensive manner.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Zinzalla, Giovanna (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London, England : Future Science Ltd (Unitec House, 2 Albert Place, London N3 1QB, UK), [2013]
Temas:
Protein-protein interactions.
Drug development.
Proteins > metabolism
Drug Discovery > methods
Interactions protéine-protéine.
Médicaments > Développement.
Drug development
Protein-protein interactions
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Understanding and exploiting protein-protein interactions as drug targets / Giovanna Zinzalla
  • Protein-protein interactions : an emerging class of molecular targets for anticancer drugs / Alex W. White, Jitka Soukupová & Andrew D. Westwell
  • Druggability of protein-protein interactions / Veronique Hamon & Xavier Morelli
  • Chemical library screening approaches to aid the design of protein-protein inhibitors / Luca Laraia & David R. Spring
  • Peptides as protein-protein interaction modulators / Erika Nieddu, Luisa Merello & Carlo Bidoia
  • Constrained peptide helices / Andrew B. Mahon & Paramjit S. Arora
  • Synthesis of peptidomimetic scaffolds / Andrew J. Wilson
  • Computational approaches for the design of protein-protein interaction inhibitors / Wenbo Yu, Olgun Guvench & Alexander D. MacKerell Jr.
  • Biochemical assays and biophysical tools for inhibitor identification and validation / Adrian Fowkes, Helene Bertrand & Geoff Wells
  • Cell-based assays for identifying, validating and optimizing protein-protein interaction modulators / Abigail L. Male & Ali Tavassoli
  • Future directions / Alexander L. Breeze
  • Index.

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