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Blockbuster Drugs : the Rise and Decline of the Pharmaceutical Industry.

Blockbuster drugs-each of which generates more than a billion dollars a year in revenue-have revolutionized the industry since the early 1980s, when sales of Tagamet alone transformed a minor Philadelphia-based firm into the world's ninth-largest pharmaceutical company. In Blockbuster Drugs, Ji...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Li, Jie Jack
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Oxford University Press, USA, 2013.
Temas:
Acceso en línea:Texto completo

MARC

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505 0 |a Cover; Contents; Preface; 1. Before the Age of Blockbuster Drugs; 2. Beginning of an Era: The First Blockbuster; 2.1. James Black and the Discovery of Tagamet; 2.2. From a Frog into a Prince; 2.3. Zantac and More "Me-Toos"; 2.4. Lessons; 3. More Blockbuster Drugs for Ulcers: Prilosec, Nexium, and Other Proton-Pump Inhibitors; 3.1. Better Ulcer Drugs Still Needed; 3.2. Prilosec; 3.3. Nexium; 3.4. "Me-Too" Proton-Pump Inhibitors; 3.5. The Saga Continues-Ulcers Are Caused; 4. Antihistamines as Allergy Drugs; 4.1. What Causes Allergies?; 4.2. Conventional Antihistamines. 
505 8 |a 4.3. Second-Generation Antihistamines5. Blood Thinners: From Heparin to Plavix; 5.1. Tales of Two Old Drugs: Heparin and Warfarin; 5.2. Good Old Aspirin; 5.3. From Ugly Duckling to Beautiful Swan-From Ticlid to Plavix; 5.4. Blood Feud; 5.5. Beyond Plavix; 6. Conquest of Pain: Analgesics: From Morphine to Lyrica; 6.1. Aspirin and Other NSAIDs; 6.2. Celebrex and COX-2 Inhibitors; 6.3. Morphine and Opiates; 6.4. Fentanyl and Opioids; 6.5. Effexor and Other Antidepressants; 6.6. Parke-Davis and Dilantin; 6.7. Parke-Davis and Neurontin; 6.8. Silverman and His Theory on GABA Compounds. 
505 8 |a 6.9. Parke-Davis and Lyrica6.10. Lyrica, the Blockbuster Windfall; 6.11. How Does Lyrica Work, Exactly?; 7. Reflections; 7.1. What Makes a Blockbuster Drug?; 7.2. How Do You Sustain Blockbuster Drugs?; 7.3. The Rise and Decline of the Pharmaceutical Industry; APPENDIX: CHEMICAL STRUCTURES OF THE DRUGS; BIBLIOGRAPHY; INDEX; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z. 
520 |a Blockbuster drugs-each of which generates more than a billion dollars a year in revenue-have revolutionized the industry since the early 1980s, when sales of Tagamet alone transformed a minor Philadelphia-based firm into the world's ninth-largest pharmaceutical company. In Blockbuster Drugs, Jie Jack Li tells the fascinating stories behind the discovery and development of these highly lucrative medicines, while also exploring the tumult the industry now faces as the ""patent cliff"" nears. Having spent most of his career in drug research and development, Li brings an insider's eye to the narra. 
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