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Genetics of Human Pain Perception : Basic to Translational Science.
Pain Genetics: Basic to Translational Science is a timely synthesis of the key areas of research informing our understanding of the genetic basis of pain. The book opens with foundational information on basic genetic mechanisms underlying pain perception and progresses recently discovered complex co...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken :
Wiley,
2013.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Pain Genetics: Basic to Translational Science; Copyright; Contents; Contributors; Editors' Biographies; 1 How Do Pain Genes Affect Pain Experience?; Introduction; Variability in Pain Experience; Heritability of Pain: Historical Roots; Why is Pain Genetics Interesting and Potentially Useful?; What Are Pain Genes?; How Many Pain Genes Are There?; How Do Pain Genes Affect Pain Experience?; Direct Effects of Allelic Variation on Pain Mechanisms; Indirect Effects of Allelic Variation on Pain Mechanisms; Disease Susceptibility Genes Versus Pain Susceptibility Genes; Perspective; Acknowledgments.
- Long-Term Potentiation and Long-Term Depression in Neuropathic Pain in MammalsNeuropathic Pain in Drosophila; Conclusions; References; 3 Defining Human Pain Phenotypes for Genetic Association Studies; Introduction; What is a Pain Phenotype?; Pain Scaling; Heritability; Genotype-Phenotype Matching; Reliability and Temporal Stability; Clinical Phenotypes; Designing Clinical Pain Genetic Studies; The Heritability of Specific Clinical Pain Conditions; Experimental Phenotypes; The Heritability of Experimental Phenotypes; Extended Phenotypes; Practical Concerns; Conclusions.
- Conflict of Interest StatementReferences; 4 Genetic Contributions to Pain and Analgesia: Interactions with Sex and Stress; Introduction; Brief Overview of Sex and Gender Differences in Pain and Analgesia; Brief Overview of Stress and Pain/Analgesia; Sex X Gene Interactions in Pain and Analgesia; Sex Chromosome-Linked Genes; Genes Related to Hormone Function; Sex-Dependent Mechanisms: Qualitative Versus Quantitative Differences; Preclinical Findings; Human Findings; Translational Findings; Summary; References; 5 Abnormal Pain Conditions in Humans Related to Genetic Mutations.
- Introduction to SCN9A, NTRK1, and NGF and the Roles They Play in PainIntroduction to SCN9A and Its Omnipotent Role in Pain Sensing; Phenotypes Caused by SCN9A Mutations; SCN9A Gene; Pathogenic SCN9A Mutations; Nav1.7 Protein; The Role of SCN9A/Nav1.7 in Pain; Future Development of Nav1.7 Antagonists; Introduction to NTRK1 and Its Role in Development and Function in the Pain and Sympathetic Nervous Systems; Phenotype Caused by NTRK1 Gene Mutations (OMIM 256800); NTRK1 Gene; Pathogenic NTRK1 Mutations; TRKA Protein; Role of NTRK1/TRKA and NGF in Pain and the HSAN Phenotype.