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Cancer and inflammation mechanisms : chemical, biological, and clinical aspects /
A new perspective on the link between inflammation and cancer Inflammation is the human body's normal biological response to threats in the modern world, as well as a defense against the harmful influence of pathogens, the environment, and poor nutrition. But what happens when the inflammatory...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, New Jersey :
Wiley,
[2014]
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Titlepage; Copyright; Contents; CONTRIBUTORS; PREFACE; CHAPTER 1 INFECTION, INFLAMMATION, AND CANCER: OVERVIEW; INFECTION, INFLAMMATION, AND CANCER: POSSIBLE MECHANISMS; PRODUCTION OF INFLAMMATORY MEDIATORS AND REACTIVE OXIDANTS; DNA AND PROTEIN DAMAGE BY ROSs AND RNSs; INFLAMMATION, EPIGENETIC MODIFICATION, AND microRNA; CONCLUDING REMARKS; REFERENCES; CHAPTER 2 STEM CELL THEORY AND INFLAMMATION-RELATED CANCER; CHRONIC INFLAMMATION AND CANCER; CANCER STEM CELLS; CARCINOGENIC FACTORS ARISING FROM CHRONIC INFLAMMATION; CHRONIC INFLAMMATION AND NORMAL STEM CELL FUNCTION.
- Inflammation and the development and regulation of cancer stem cellsconcluding remarks; references; chapter 3 epithelial-mesenchymal transition: a link between cancer and inflammation; emt: a link between cancer and inflammation; q1: how are emt-permissive, inflammatory tumor microenvironments created?; q2: which emt-promoting signals are provided by inflammatory tumor microenvironments?; q3: how do emt-promoting signals influence the migratory behavior of tumor cells?; conclusions and future prospects; references; chapter 4 role of nitrative dna damage in inflammation- related carcinogenesis.
- Dna damage during chronic inflammationliver fluke-induced cholangiocarcinoma; hpv-induced cervical cancer; ebv-induced nasopharyngeal carcinoma; dna damage induced by asbestos exposure; dna damage induced by carbon nanotube; soft tissue tumors and prognosis of tumor patients; conclusions and future prospects; references; chapter 5 lipid peroxidation-derived dna adducts and the role in inflammation-related carcinogenesis; lpo-derived reactive products contribute to dna damage; results and discussion; conclusions and future prospects; references.
- CHAPTER 6 LEVEL OF INFLAMMATION-RELATED DNA ADDUCTS IN HUMAN TISSUESLEVEL OF 4-ONE- AND 4-OHE-DERIVED DNA ADDUCTS IN HUMAN TISSUES; BIOLOGICAL PROPERTIES OF 4-ONE- AND 4-OHE-DERIVED DNA ADDUCTS; INFLAMMATION AND FORMATION OF 4-ONE; CONCLUDING REMARKS; REFERENCES; CHAPTER 7 TOLL-LIKE RECEPTORS: ROLE IN INFLAMMATION AND CANCER; TLRs AND THEIR LIGANDS; TLR SIGNALING; MYD88-DEPENDENT SIGNALING PATHWAYS; TRIF-DEPENDENT SIGNALING PATHWAYS; INNATE IMMUNE CELLS IN CANCER TISSUES; TLRs AND TUMOR MICROENVIRONMENT; TOLL-LIKE RECEPTORS IN CANCER AND TUMOR THERAPY; ANTITUMOR ACTIVITY OF TLR LIGANDS.
- ROLES OF TLRs IN CANCER PROGRESSIONCURRENT AND FUTURE DEVELOPMENTS; REFERENCES; CHAPTER 8 INFLAMMASOMES AND INFLAMMATION; NOD-LIKE RECEPTORS AND THE INFLAMMASOMES; THE NLRP3 INFLAMMASOME; THE IPAF INFLAMMASOME; THE NLRP1 INFLAMMASOME; THE NLRP12 INFLAMMASOME; THE NLRP7 INFLAMMASOME; THE NLRP6 INFLAMMASOME; THE AIM2 INFLAMMASOME; CYTOKINE TARGETS OF THE INFLAMMASOME; INFLAMMASOME DYSREGULATION IN DISEASE; CONCLUDING REMARKS; REFERENCES; CHAPTER 9 ACTIVATION-INDUCED CYTIDINE DEAMINASE: AN INTRINSIC GENOME MODULATOR IN INFLAMMATION-ASSOCIATED CANCER DEVELOPMENT.