Tabla de Contenidos:
  • 1 Pteridines
  • 1.1 Historical remarks
  • 1.2 Occurrence
  • 1.3 Biosynthesis
  • 1.4 Biochemical functions
  • References
  • 2 Neopterin
  • 2.1 Chemical characteristics
  • 2.2 Catabolism
  • 2.3 Biochemical and physiological relevance
  • References
  • 3 Measurement of Neopterin
  • 3.1 Historical remarks
  • 3.2 Measurement by reversed phase HPLC without pretreatment of samples
  • 3.3 Measurement of neopterin by reversed phase HPLC with on-line deproteinization
  • 3.4 Measurement of neopterin by immunoassays
  • References.
  • 4 Normal Ranges of Neopterin Concentrations in Various Body Fluids. 4.1 Normal ranges of neopterin concentrations in urine
  • 4.2 Normal ranges of neopterin concentrations in serum
  • 4.3 Normal ranges of neopterin concentrations in cerebrospinal fluid
  • 4.4 Normal ranges of neopterin concentrations in synovial fluid
  • 4.5 Normal ranges of neopterin concentrations in saliva
  • 4.6 Discussion
  • References
  • 5 Biosynthesis of Pteridines and the Human Immune System
  • 5.1 Immunological activation and cytokines
  • 5.2 Cytokines and pteridine biosynthesis.
  • 5.3 Inducers of pteridine synthesis in human cells. 5.4 Cell culture techniques
  • 5.5 Determination of pteridines in cell homogenates and supernatants
  • 5.6 Enzyme activities of pteridine synthesis in cell extracts
  • 5.7 Biological significance of cytokine-induced pteridine synthesis
  • References
  • 6 Neopterin in Organ Transplantation
  • 6.1 Renal transplantation
  • 6.2 Transplantation of solid organs other than kidney
  • 6.3 Transplantation of bone marrow
  • References
  • 7 Neopterin in Autoimmune Diseases and Related Inflammatory Disorders.
  • 7.1 Neopterin in rheumatoid arthritis. 7.2 Neopterin in inflammatory bowel diseases
  • 7.3 Neopterin in autoimmune diabetes
  • 7.4 Neopterin in autoimmune diseases of the thyroid
  • 7.5 Neopterin in systemic lupus erythematosus
  • 7.6 Neopterin in multiple sclerosis
  • 7.7 Neopterin in sarcoidosis
  • 7.8 Neopterin in celiac disease
  • References
  • 8 Neopterin in Malignant Diseases
  • 8.1 Hematological malignancies
  • 8.2 Gynecological malignancies
  • 8.3 Malignancies of the urogenital tract
  • 8.4 Lung cancer.
  • 8.5 Gastrointestinal, pancreatic and hepatic cancer. 8.6 Breast cancer
  • 8.7 Cancers of the head and neck region
  • 8.8 Malignant melanoma
  • 8.9 Neopterin in malignant diseases
  • a summary
  • References
  • 9 Neopterin in Infectious Diseases
  • 9.1 Infections by viruses
  • 9.2 Neopterin during infection by human immunodeficiency virus type 1 (HIV-1) and the acquired immunodeficiency syndrome (AIDS)
  • 9.3 Infections by intracellular protozoa
  • 9.4 Infections by bacteria
  • 9.5 Neopterin during sepsis and trauma
  • References.