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MicroRNAs in Toxicology and Medicine.
During the past decade it has become evident that microRNAs regulate gene expressions and control many developmental and cellular processes in eukaryotic organisms. Recent studies suggest that microRNAs play an important role in toxicogenomics and are likely to play an important role in a range of h...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken :
Wiley,
2013.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Acknowledgments; Part I microRNAs and Toxicology; Chapter 1 Introduction; References; Chapter 2 Environmental Toxicants and Perturbation of miRNA Signaling; 2.1 Introduction; 2.2 miRNAs: Description and Biological Significance; 2.2.1 miRNA Biosynthesis and Processing; 2.2.2 Interaction of miRNAs with mRNA Targets; 2.3 Environmental Toxicant-Associated miRNA Perturbations; 2.3.1 Toxicant Class 1: Carcinogenic Metals (Arsenic and Cadmium); 2.3.1.1 Arsenic; 2.3.1.2 Cadmium.
- 2.3.2 Toxicant Class 2: Air Toxicants (Formaldehyde, Diesel Exhaust Particles, Cigarette Smoke)2.3.2.1 Formaldehyde; 2.3.2.2 Diesel Exhaust Particles (DEPs); 2.3.2.3 Cigarette Smoke; 2.3.3 Toxicant Class 3: Polycyclic Aromatic Hydrocarbon (B(a)P); 2.3.4 Toxicant Class 4: Endocrine Disruptors (BPA, DDT, Fludioxonil, Fenhexamid, and Nonylphenol); 2.3.4.1 BPA, DDT, Fludioxonil, Fenhexamid; 2.3.4.2 Nonylphenol (NP); 2.4 Conclusions and Future Directions; Acknowledgments; References; Chapter 3 microRNAs in Drug-Induced Liver Toxicity; 3.1 Introduction; 3.2 miRNA Tissue Distribution and Abundance.
- 3.2.1 miRNA in Solid Tissues3.2.2 microRNA in Body Fluids; 3.3 miRNA and Drug-Induced Liver Toxicity; 3.3.1 Acetaminophen; 3.3.2 Carbon Tetrachloride (CCl_4); 3.3.3 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD); 3.3.4 Benzo[a]pyrene; 3.3.5 Tamoxifen; 3.3.6 Others; 3.4 Circulating miRNAs as Potential Biomarkers for Drug-Induced Liver Toxicity; 3.4.1 Introduction of Circulating miRNAs; 3.4.1.1 Exosomes; 3.4.1.2 HDL; 3.4.1.3 Ago2; 3.4.2 Blood miRNAs in Drug-Induced Liver Toxicity; 3.4.3 Urine miRNAs in Drug-Induced Liver Toxicity; 3.4.4 Technique Challenges.
- 3.5 Mechanistic Studies and PerspectivesDisclaimer; References; Chapter 4 Fishing for microRNAs in Toxicology; 4.1 microRNAs in Toxicology; 4.2 Fish Models in Toxicology; 4.2.1 Small Fish Models in Toxicology; 4.2.2 Large Fish Models in Toxicology; 4.3 Fish as Models for Studying miRNA Function; 4.3.1 miRNA Studies in Zebrafish; 4.3.2 miRNA Studies in Other Fish Models; 4.4 Application of Fish Models in Toxicity Studies of miRNA Alterations; 4.4.1 Zebrafish in Toxicity Studies of miRNA Alterations; 4.4.2 Other Fish Models in Toxicity Studies of miRNA Alterations; 4.5 Summary; Acknowledgments.