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Computational biology : new research /
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Nova Science Publishers,
©2009.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Computational Biology: New Research; Contents; Preface; Expressed Sequence Tags in Cancer Genomics; Abstract; Introduction; Gene Expression; SNPs; Databases; Advantages and Limitations; Conclusions; Acknowledgement; References; Short Commentaries; Protein Bioinformatics for Drug Discovery Concavity Druggability and Antibody Druggability; Abstract; Introduction; Protein Sequence and Structure Analysis; Concavity Druggability; Antibody Modeling and Druggability; Conclusion; References.
- A Linkage Disequilibrium-Based Statistical Approach to Discovering Interactions among SNP Alleles at Multiple Loci Contributing to Human Skin Pigmentation VariationAbstract; Introduction; Materials and Methods; Results; Conclusion; References; Sufficient Conditions for Exact Penalty in Constrained Optimization on Complete Metric Spaces; Abstract; Introduction; The Main Results; Proofs of Theorems 2.1 and 2.2; References; How to Create a Computational Medicine Study; Abstract; Introduction; Research Design: The First Step; Database and Tool for Manipulation; Simulation Experiment; References.
- Identifying Related Cancer TypesAbstract; Introduction; Methods; Results; Conclusion; Acknowledgment; References; Research and Review Studies; Sample Size Calculation and Power in Genomics Studies; Introduction; Preliminaries; General Simulation-Based Approaches to Sample Size and Power Planning; Methods Assuming Independence in Gene Expression; Methods Accounting for Dependence in Gene Expression; Methods for Controlling Family-Wise Error; Other Approaches and Relevant Literature; Discussion; Acknowledgment; References.
- Coupling Computational and Experimental Analysis for the Prediction of Transcription Factor E2F Regulatory Elements in the Human Gene PromoterAbstract; Introduction; DNA Microarray and Bioinformatics; Computational Prediction of E2F Binding Site Locations; Experimental Verification of E2F Binding Site Locations; ChIP-on-Chip; Systems Biology; Conclusion; Acknowledgement; References; Solving a Stochastic Generalized Assignment Problem with Branch and Price; Abstract; Introduction; Literature Review; Mathematical Formulation; Reformulating the Stochastic GAP; Branch-and-Price Algorithm.
- Computational ResultsSummary and Conclusions; Acknowledgments; References; Reconstruction and Analysis of Large-Scale Phylogenetic Data, Challenges abd Opportunities; Abstract; Introduction; The Standard Phylogenetic Analysis Pipeline; Scaling up the Pipeline; Challenges in the Analysis and Interpretation of Large-Scale Datasets; Addressing Biological Questions Through Phylogenomics; References; Chromatin Fiber: 30 Years of Models; Abstract; Introduction; Nucleosome/Chromatosome as the Chromatin Fundamental Subunit; Nucleosome Computation; Nucleosomal Arrays and the ""30 nm Fiber""