Posttranscriptional gene regulation : RNA processing in eukaryotes /

Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focusing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA edi...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Wu, Jane Y. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Weinheim, Germany : Wiley-Blackwell, 2013.
Edición:First edition.
Temas:
Genetic regulation.
Eukaryotic cells.
Gene Expression Regulation
RNA Processing, Post-Transcriptional > genetics
Eukaryotic Cells
Régulation génétique.
Cellules eucaryotes.
Eukaryotic cells
Genetic regulation
Eukaryoten
Posttranskriptionelle Regulation
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover; Related Titles; Title page; Copyright page; Contents; Foreword; List of Contributors; 1: The Role of Cotranscriptional Recruitment of RNA-Binding Proteins in the Maintenance of Genomic Stability; 1.1 Introduction; 1.2 THO/TREX; 1.2.1 THO/TREX in Saccharomyces cerevisiae; 1.2.2 THO/TREX in Higher Eukaryotes; 1.2.3 THO/TREX and R-loop Formation; 1.3 Linking Transcription to Export of mRNP; 1.3.1 The Thp1-Sac3-Sus1-Cdc31 (THSC) Complex; 1.3.2 SR Proteins; 1.3.3 The Exon Junction Complex; 1.3.4 The Exosome; 1.4 Cotranscriptional R-loop Formation; 1.4.1 R-loops in Escherichia coli.
  • 1.4.2 Naturally Occurring R-loops1.4.3 TREX Protects against R-loop Formation; 1.4.4 SR Proteins Protect against R-loop Formation; 1.5 R-loop-induced Double-Stranded (ds) DNA Breaks; 1.5.1 Class Switch Recombination; 1.5.2 Formation of Double-Strand Breaks; 1.5.3 Rrm3 and Pif1 DNA Helicases; 1.6 Concluding Remarks; References; 2: Transcription Termination by RNA Polymerase II; 2.1 Messenger RNA Gene Termination; 2.1.1 The Allosteric Model; 2.1.2 The Torpedo Model; 2.2 Small Nucleolar RNA Gene Termination Pathway; 2.3 Choice between the Two Termination Pathways.
  • 2.4 Regulation of Transcription by Termination2.4.1 Transcription Attenuation, Promoter Upstream/Associated Transcription, and Pausing of RNApII; 2.4.2 Alternative Polyadenylation and Termination; 2.5 Mechanisms of Termination by Other RNA Polymerases; 2.6 Future Perspectives; Acknowledgments; References; 3: Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in RNA Editing; 3.1 Introduction; 3.2 The RNA Editing Kinship; 3.3 The ADAR Gene Family; 3.4 The Role of RNA in the A-to-I Editing Mechanism; 3.5 Splice Site Alterations.
  • 3.6 A-to-I RNA Recoding Modifies Proteins Such As Neurotransmitters3.6.1 Glutamate Receptor Editing
  • GluR-B; 3.6.2 Serotonin Receptor Editing
  • 5-HT2CR; 3.7 Cellular Effects and in Vivo Phenotypes of ADAR Gene Inactivation; 3.8 Noncoding RNA and Repetitive Sequences; 3.9 Effects on the RNA Interference Silencing Pathway; 3.10 Effects on MicroRNA Processing and Target Selection; 3.11 RNA Editing Role as an Antiviral Mechanism; 3.12 Conclusions; Acknowledgments; References; 4: Posttranslational Modification of Sm Proteins: Diverse Roles in snRNP Assembly and Germ Line Specification.
  • 4.1 Introduction4.2 Protein Methylation
  • Flavors and Functions; 4.3 Sm Proteins Contain sDMA- and aDMA-Modified Arginines; 4.4 SnRNP Assembly, the Survival Motor Neuron (SMN) Complex, and Spinal Muscular Atrophy (SMA); 4.5 PRMT5 and PRMT7
  • The Sm Protein Methyltransferases; 4.6 Sm Protein Methylation is Required for sn/RNP Assembly in Mammals; 4.7 Sm Protein Methylation in Drosophila; 4.8 Unresolved Questions: Sm Protein Methylation and snRNP Assembly; 4.9 Conclusion
  • The Evolution of snRNP Assembly; 4.10 Sm Proteins Are Required for Germ Cell Specification.

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