The Neutrophils : New Outlook for Old Cells.

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This is a third edition of the popular book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been recently demonstrated to be a major contributor to tumor associa...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Gabrilovich, Dmitry I.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Singapore : World Scientific Publishing Company, 2013.
Edición:3rd ed.
Temas:
Immunology.
Neutrophils.
Allergy and Immunology
Neutrophils
Immunologie.
Neutrophiles.
Immunology
Acceso en línea:Texto completo
Tabla de Contenidos:
  • List of Contributors; Preface; Contents; Chapter 1: Molecular Regulation of Granulopoiesis Sachin Kumar and Marie-Dominique Filippi; 1.1 Introduction; 1.2 Sequential Steps of PMN Development; 1.2.1 From HSC to granulocytic precursors; 1.2.2 Final stages of granulocytic maturation
  • Acquisition of granulocyte characteristics; 1.3 Regulation of Steady State Granulopoiesis; 1.3.1 Growth factors; 1.3.1.1 G-CSF: Sources and functions; 1.3.1.2 G-CSFR and downstream signaling pathways; 1.3.1.3 G-CSFR signaling: Instructive or permissive?; 1.3.2 Transcription factors (TF)
  • 2.2.4 p40phox2.2.5 Rac; 2.2.6 Rap1A; 2.3 Oxidase Protein Binding Interactions; 2.3.1 Flavocytochrome b-p47phox interactions; 2.3.2 p40phox-p47phox-p67phox interactions; 2.3.3 Rac interactions; 2.4 Model of NADPH Oxidase Assembly; 2.5 Oxidant Production; 2.5.1 Superoxide anion (O2
  • ); 2.5.2 Hydrogen peroxide (H2O2); 2.5.3 Hypochlorous acid (HOCl); 2.5.4 Hydroxyl radical (HO); 2.5.5 Singlet oxygen (1O2 *); 2.5.6 Nitric oxide (NO) and peroxynitrite (ONOO- ); 2.7 Summary; Acknowledgments; References
  • Chapter 3: Novel Neutrophil Receptors and Their Signal Transduction Nicole R. Fortenbery, Xianhong Chen and Sheng Wei3.1 Introduction; 3.2 Siglecs; 3.2.1 Identification of siglecs; 3.2.2 Characterization of siglecs; 3.2.3 Siglec-5; 3.2.4 Siglec-9; 3.2.5 Siglec-14; 3.2.6 Siglec signaling; 3.2.7 Clinical applications; 3.3 Triggering Receptor Expressed by Myeloid Cells (TREM); 3.3.1 Identification of TREM; 3.3.2 Characterization of TREM-1; 3.3.3 TREM-1-DAP12 and signal transduction; 3.3.4 TREM-1 ligand(s); References
  • Chapter 4 Mechanisms of Neutrophil Migration Fong W. Lam, Rolando E. Rumbaut and Alan R. Burns4.1 Introduction; 4.2 Historical Perspective on Leukocyte Adhesion and Emigration (1669-1955); 4.2.1 The first observations; 4.2.2 Mechanistic insight; 4.3 Molecular Adhesive Events Preceding Neutrophil Transendothelial Migration; 4.4 Integrin Regulation of Neutrophil Transendothelial Migration; 4.5 Paracellular Neutrophil Transendothelial Migration; 4.5.1 Endothelial cleft organization; 4.5.2 Tight junctions and preferred transmigration sites; 4.5.3 Adherens junctions; 4.5.4 Gap junctions

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