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Lecture Notes : Clinical Pharmacology and Therapeutics.
Clinical Pharmacology and Therapeutics Lecture Notes provides a clear and accessible overview of all the key prescribing topics needed for medical finals and beyond. Detailed coverage and discussion of pharmacology in a clinical context, combined with an easy-to-understand, readable style, helps imp...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken :
Wiley,
2013.
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| Edición: | 9th ed. |
| Colección: | Lecture Notes.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Clinical Pharmacology and Therapeutics : Lecture Notes; Contents; Contributors; Preface; Foreword; Part 1 Principles of clinical pharmacology; 1 Pharmacodynamics and pharmacokinetics; Introduction; Principles of drug action (pharmacodynamics); Mechanism of drug action; Action on a receptor; Action on an enzyme; Action on membrane ionic channels; Cytotoxic actions; Dose-response relationship; Principles of pharmacokinetics; Absorption; Distribution; Plasma protein binding; Clearance; Linear versus non-linear kinetics; Principles of drug elimination; Drug metabolism; Metabolic drug interactions.
- InductionInhibition; Genetic factors in metabolism; Renal excretion; 2 Clinical trials and drug development; Introduction; Drug development and regulation; Preclinical studies; Animal studies of efficacy and toxicity; Clinical trials; Phase I clinical trials; Phase II clinical trials; Phase III clinical trials; Phase IIIb and IV studies; Yellow card scheme; Translational research; Part 2 Aspects of therapeutics; 3 Drugs and gastrointestinal disease; Introduction; Gastro-oesophageal reflux disease; Relevant pathophysiology; Drugs used in the treatment of gastro-oesophageal reflux disease.
- Drugs that inhibit gastric acid secretionDrugs that act on oesophageal and/or gastric motility; Peptic ulcer; Relevant pathophysiology; Drugs used in the treatment of peptic ulcer; Drug combinations to eradicate H. pylori; Nausea and vomiting; Relevant pathophysiology; Drugs used in treatment of vomiting; Diarrhoea and constipation; Diarrhoea; Irritable bowel syndrome; Pancreatic insufficiency; Drugs used in non-specific diarrhoea; Constipation; Inflammatory bowel disease; Relevant pathophysiology; Drugs used in the treatment of inflammatory bowel disease.
- Drugs adversely affecting gastrointestinal function4 Management of coronary artery disease and its complications; Introduction; Angina pectoris and acute coronary syndromes; Aims of treatment; Relevant pathophysiology; Drugs used in angina; General principles of management of angina; Cardiac arrhythmia; Relevant pathophysiology; Classification of anti-arrhythmic drugs; Pharmacological versus non-pharmacological therapy; Class I agents; Class II agents; Class III agents; Class IV agents; Digitalis glycosides; Adenine nucleotides; Heart failure; Definition; Relevant pathophysiology.
- Neuroendocrine activation in heart failureDiuretics; Neuroendocrine antagonists; Drugs with a positive inotropic effect; Drugs affecting preload; Drugs affecting preload and afterload; General principles of management of heart failure; Long-term management of chronic heart failure; 5 Primary and secondary prevention of cardiovascular disease; Introduction; Hypertension; Relevant pathophysiology; Primary and secondary hypertension; Benefits of treatment; Principles of antihypertensive treatment; Antihypertensive drugs; Hypertensive emergencies; Cholesterol and lipids; Aim.