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Protein-protein interactions in drug discovery /
Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of prote...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Weinheim :
Wiley-VCH,
2013.
|
| Colección: | Methods and principles in medicinal chemistry ;
v. 56. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Protein-protein interactions in drug discovery / |c edited by Alexander Dömling. |
| 260 | |a Weinheim : |b Wiley-VCH, |c 2013. | ||
| 300 | |a 1 online resource (xxi, 314 pages) : |b illustrations | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Methods and principles in medicinal chemistry ; |v v. 56 | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Protein-protein interactions: an vverview / Christian Ottman -- Prediction of intra- and interspecies protein-protein interactions facilitating systems biology studies / Sylvia Schleker, Seshan Ananthasubramanian, Judith Klein-Seetharaman, Madhavi K Ganapathiraju -- Modulators of protein-protein interactions: importance of three-dimensionality / David C Fry, Sung-Sau So -- A leap into the chemical space of protein-protein interaction inhibitors / Bruno O Villoutreix, C Labbé, David Lagorce, Guillaume Laconde, Olivier Sperandio -- Interactive technologies for leveraging the known chemistry of anchor residues to disrupt protein interactions / Carlos J Camacho, David R Koes, Alexander S Dömling -- SH3 domains as drug targets / James Luccarelli, Sam Thompson, Andrew D Hamilton -- p53/MDM2 antagonists: towards nongenotoxic anticancer treatments / Kareem Khoury, Tad A Holak, Alexander Dömling -- Inhibition of LFA-1/ICAM interaction for the treatment of autoimmune diseases / Kevin M Guckian, Daniel M Scott -- The PIF pocket of AGC kinases: a target site for allosteric modulators and protein-protein interaction inhibitors / Matthias Engel -- Retosiban and epelsiban: potent and selective orally available oxytocin antagonists / Alan D Borthwick, John Liddle -- Peptidic inhibitors of protein-protein interactions for cell adhesion receptors: RGD peptides and beyond / Carlos Mas-Moruno, Horst Kessler -- REPLACE strategy for generating non-ATP-competitive inhibitors of cell cycle protein kinases / Campbell McInnes -- Index. | |
| 520 | |a Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the devel. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Protein-protein interactions. | |
| 650 | 0 | |a Protein binding. | |
| 650 | 0 | |a Proteins |x Inhibitors. | |
| 650 | 0 | |a Carrier proteins. | |
| 650 | 1 | 2 | |a Carrier Proteins |
| 650 | 2 | 2 | |a Drug Discovery |
| 650 | 2 | 2 | |a Protein Interaction Domains and Motifs |
| 650 | 2 | |a Protein Binding | |
| 650 | 6 | |a Interactions protéine-protéine. | |
| 650 | 6 | |a Protéines |x Fixation. | |
| 650 | 6 | |a Protéines |x Inhibiteurs. | |
| 650 | 6 | |a Protéines de liaison. | |
| 650 | 7 | |a MEDICAL |x Drug Guides. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Nursing |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Pharmacy. |2 bisacsh | |
| 650 | 7 | |a Carrier proteins |2 fast | |
| 650 | 7 | |a Protein binding |2 fast | |
| 650 | 7 | |a Protein-protein interactions |2 fast | |
| 700 | 1 | |a Dömling, Alexander. | |
| 758 | |i has work: |a Protein-protein interactions in drug discovery (Text) |1 https://id.oclc.org/worldcat/entity/E39PCFP6MB76myWKGCf3DBYyr3 |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |t Protein-protein interactions in drug discovery. |d Weinheim : Wiley-VCH Verlag GmbH, 2013 |z 9783527331079 |
| 830 | 0 | |a Methods and principles in medicinal chemistry ; |v v. 56. | |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=1117395 |z Texto completo |
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