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Stereoselective synthesis of drugs and natural products /
Emphasizing synthetic strategy and practice, Stereoselective Synthesis of Drugs and Natural Products features experimental procedures for stereoselective synthetic reactions applicable to drug targets and natural products. Compiling material from leading contributors into one cohesive resource, this...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, New Jersey :
Wiley,
[2013]
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
| LEADER | 00000cam a2200000 i 4500 | ||
|---|---|---|---|
| 001 | EBOOKCENTRAL_ocn823930418 | ||
| 003 | OCoLC | ||
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| 008 | 130109s2013 nju ob 001 0 eng | ||
| 010 | |a 2013000938 | ||
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| 082 | 0 | 0 | |a 615.1/9 |2 23 |
| 049 | |a UAMI | ||
| 245 | 0 | 0 | |a Stereoselective synthesis of drugs and natural products / |c edited by Vasyl Andrushko, Natalia Andrushko, Karlsruhe, Germany. |
| 264 | 1 | |a Hoboken, New Jersey : |b Wiley, |c [2013] | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 500 | |a Includes index. | ||
| 588 | 0 | |a Print version record and CIP data provided by publisher. | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a V. 1. Part I: general methods and strategies -- Principles, concepts, and strategies of stereoselective synthesis -- Chiral auxiliaries in drug synthesis -- Solid-phase organic synthesis of drugs and natural products -- Asymmetric phase-transfer catalysis -- Microwave-assisted stereoselective synthesis -- Application of microreactor methodology for organic synthesis -- Part II: stereoselective synthesis by bond formation -- Stereoselective methods for C-C bond formation -- Asymmetric [alpha]-alkylation of aldehydes, ketones, and carboxylic acids -- Asymmetric aldol reactions in the total syntheses of natural products -- Asymmetric michael addition and related reactions -- Construction of polypropionate fragments in natural product synthesis -- Organocatalytic conjugate addition in stereoselective synthesis -- Stereoselective nozaki-hiyama-kishi reaction -- Transition-metal-catalyzed asymmetric C-C cross-couplings in stereoselective synthesis -- Asymmetric hydroformylation, hydroxycarbonylation, and alkoxycarbonylation for stereoselective synthesis -- Intramolecular oxycarbonylation in stereoselective synthesis -- Stereoselective cycloaddition reactions -- Sigmatropic rearrangements in stereoselective synthesis -- Ring contraction reactions in the total synthesis of biologically active natural products -- Electrocyclic reactions in stereoselective synthesis -- Transannular cyclization in natural product total synthesis -- Cascade reactions in stereoselective synthesis -- Sulfur dioxide: a powerful tool for the stereoselective construction of c-c bonds -- Transition metal c-h activation: application to stereoselective synthesis of natural products and drugs -- Metathesis reactions in drug and natural product synthesis -- Radicals in stereoselective C-C bond formation -- Trifluoromethyl (CF3) group insertion methods in stereoselective synthesis -- Stereoselective organocatalyzed C-C bond-forming reactions -- Enzyme-catalyzed stereoselective C-C bond formation reactions in total syntheses. | |
| 505 | 0 | |a V.2. Stereoselective methods for C-H bond formation -- Stereoselective hydrogenation of C=C bonds: application to drug and natural product synthesis -- Asymmetric hydrogenation of C=O and C=N bonds in stereoselective synthesis -- Asymmetric protonation of carbanions and polar double bonds: application to total syntheses -- Organocatalytic reduction in stereoselective synthesis -- Biocatalytic asymmetric reduction of C=O and activated C=C bonds in stereoselective synthesis -- Stereoselective methods for C-O bond formation -- Transition-metal-catalyzed stereoselective oxidations in drug and natural product synthesis -- Asymmetric epoxidation in stereoselective synthesis -- Biocatalytic asymmetric oxidations in stereoselective synthesis -- Ether transfer methodology: application to the synthesis of polyketide natural products -- Stereoselective formation of 2-deoxyglycosidic bonds in biologically active natural products -- Stereoselective methods for C-N Bond formation -- Asymmetric hydroamination and reductive amination in total synthesis -- Carboamination and alkylative cyclization with C-N bond formation in stereoselective syntheses -- Cycloadditions with stereoselective C-N bond formation in total syntheses -- Stereoselective formation of other C-heteroatomand other bonds -- Stereoselective halogenations -- Stereoselective synthesis of halogenated natural products -- Asymmetric fluorination methods: application in the stereoselective synthesis of fluorinated drugs -- Enzymatic halogenation in stereoselective synthesis -- Stereoselective carbon-sulfur (C-S) bond formation -- Stereoselective methods for carbon-phosphorus (C-P) bond formation -- Transition-metal-catalyzed asymmetric sulfoxidation in drug and natural product synthesis -- Part III: methods of analysis and chiral separation -- NMR spectroscopy in drug and natural product analysis -- Determination of enantiomeric purity and absolute configuration by NMR spectroscopy -- Solid-state NMR spectroscopy in drug design and discovery -- Capillary electrophoresis in chiral separations -- Determination of absolute configuration using chiroptical methods -- Chiral chromatographic methods in the analysis and purification of enantiomers -- X-ray crystallography and 1H NMR anisotropy methods for determination of absolute configurations -- Crystallization-based separation of enantiomers -- Enzymatic dynamic kinetic resolution in stereoselective synthesis. | |
| 520 | |a Emphasizing synthetic strategy and practice, Stereoselective Synthesis of Drugs and Natural Products features experimental procedures for stereoselective synthetic reactions applicable to drug targets and natural products. Compiling material from leading contributors into one cohesive resource, this practical resource on synthetic methodology, reaction mechanisms, and applications for medicinal chemistry and drug discovery explores strategy and interdisciplinary work, laboratory synthesis for natural products, the preparative aspects of stereoselective synthesis for drugs, natural produ. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Chiral drugs. | |
| 650 | 0 | |a Drug development. | |
| 650 | 0 | |a Molecular pharmacology. | |
| 650 | 0 | |a Stereoisomers. | |
| 650 | 1 | 2 | |a Pharmaceutical Preparations |x chemical synthesis |
| 650 | 2 | 2 | |a Biological Factors |x chemical synthesis |
| 650 | 2 | 2 | |a Drug Discovery |
| 650 | 2 | 2 | |a Stereoisomerism |
| 650 | 6 | |a Médicaments chiraux. | |
| 650 | 6 | |a Médicaments |x Développement. | |
| 650 | 6 | |a Pharmacologie moléculaire. | |
| 650 | 6 | |a Stéréo-isomères. | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a Stereoisomers |2 fast | |
| 650 | 7 | |a Chiral drugs |2 fast | |
| 650 | 7 | |a Drug development |2 fast | |
| 650 | 7 | |a Molecular pharmacology |2 fast | |
| 700 | 1 | |a Andrushko, Vasyl, |d 1976- |e editor. | |
| 700 | 1 | |a Andrushko, Natalia, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Stereoselective synthesis of drugs and natural products. |d Hoboken, New Jersey : Wiley, [2013] |z 9781118032176 |w (DLC) 2012048287 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=1435995 |z Texto completo |
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