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Lysophospholipid receptors : signaling and biochemistry /
"This state-of-the-art reference addresses lysophospholipids, a special kind of fat that has been found to have a growing number of receptors within the cell and that has important, natural roles in the body, being essential for normal reproduction, development, maturation and life. This book c...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, N.J. :
Wiley,
©2013.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- TITLE PAGE; COPYRIGHT PAGE; PREFACE; CONTRIBUTORS; CHAPTER 1 Lysophosphatidic Acid (LPA) Receptor Signaling; 1.1. INTRODUCTION; 1.2. LPA METABOLISM; 1.3. AUTOTAXIN; 1.4. LPA RECEPTORS; 1.5. LPA RECEPTOR AGONISTS AND ANTAGONISTS; CHAPTER 2 Sphingosine 1-Phosphate (S1P) Receptors; 2.1. INTRODUCTION; 2.2. S1P METABOLISM/ENZYME, AND TRANSPORT; 2.3. S1P RECEPTOR SUBTYPES, AND PHYSIOLOGICAL FUNCTIONS; 2.4. CONCLUDING REMARKS; CHAPTER 3 Global Gene Expression Program of Lysophosphatidic Acid (LPA)-Stimulated Fibroblasts; 3.1. INTRODUCTION; 3.2. THE GLOBAL TRANSCRIPTIONAL RESPONSE OF MEFS TO LPA.
- 3.3. UPREGULATED GENES3.4. DOWNREGULATED GENES; 3.5. INDUCTION OF GENES THAT ENCODE SECRETED FACTORS; 3.6. OVERLAP BETWEEN THE EXPRESSION PROFILES OF LPA AND EGF; 3.7. CONCLUSIONS; ACKNOWLEDGMENTS; CHAPTER 4 Identification of Direct Intracellular Targets of Sphingosine 1-Phosphate (S1P); 4.1. INTRODUCTION; 4.2. INTRACELLULAR TARGETS FOR S1P; 4.3. METHODS TO IDENTIFY INTRACELLULAR S1P TARGETS; 4.4. OTHER POTENTIALLY USEFUL METHODS TO IDENTIFY LIPID BINDING PROTEINS; 4.5. CONCLUDING REMARKS; ACKNOWLEDGMENTS.
- CHAPTER 5 Lysophospholipid Receptor Signaling Platforms: The Receptor Tyrosine Kinase-G Protein-Coupled Receptor Signaling Complex5.1. INTRODUCTION; 5.2. LYSOPHOSPHOLIPID RECEPTOR-RECEPTOR TYROSINE KINASE COMPLEXES; 5.3. OTHER LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS; 5.4. OTHER EXAMPLES OF RTK-GPCR SIGNALING PLATFORMS; 5.5. INTERACTION OF RGS PROTEINS WITH RECEPTOR TYROSINE KINASE-LYSOPHOSPHOLIPID RECEPTOR SIGNALING COMPLEXES; 5.6. S1P AND RTK TRANSACTIVATION; 5.7. APPROACHES FOR THE STUDY OF RECEPTOR TYROSINE KINASE-LYSOPHOSPHOLIPID RECEPTOR SIGNALING COMPLEXES.
- 5.8. SOME USEFUL PROTOCOLS FOR STUDYING RTK-LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS5.9. CONCLUSION; ACKNOWLEDGMENT; CHAPTER 6 Autotaxin: A Unique Ecto-Type Pyrophosphodiesterase with Diverse Functions; 6.1. HISTORY OF AUTOTAXIN (ATX); 6.2. STRUCTURE OF ATX; 6.3. EXPRESSION OF ATX; 6.4. ATX KNOCKOUT MICE AND TRANSGENIC MICE; 6.5. ROLE OF ATX IN BLOOD VESSEL FORMATION; 6.6. ROLE OF ATX IN CANCER; 6.7. CLINICAL ASPECTS OF ATX; 6.8. ATX INHIBITORS; 6.9. AUTOTAXIN RESEARCH PERSPECTIVES.
- CHAPTER 7 Studies on Autotaxin Signaling in Endocytic Vesicle Biogenesis and Embryonic Development Using Whole Embryo Culture and Electroporation7.1. INTRODUCTION; 7.2. RESULTS AND DISCUSSION; 7.3. METHODS; ACKNOWLEDGMENTS; CHAPTER 8 Standardization and Quantification of Lysophosphatidic Acid Compounds by Normal-Phase and Reversed-Phase Chromatography-Tandem Mass Spectrometry; 8.1. PREPARATION AND HANDLING OF LYSOPHOSPHATIDIC ACID (LPA) COMPOUNDS; 8.2. 1H AND 31P NMR CHARACTERIZATION; 8.3. LC/MS/MS OF LPA COMPOUNDS; 8.4. DISCUSSION; ACKNOWLEDGMENTS.