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|a Bioactive heterocyclic compound classes :
|b pharmaceuticals /
|c edited by Jürgen Dinges and Clemens Lamberth.
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260 |
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|a Weinheim :
|b Wiley-VCH ;
|a Chichester :
|b John Wiley [distributor],
|c 2012.
|
300 |
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|a 1 online resource (xv, 356 pages)
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|a text
|b txt
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|a Includes bibliographical references and index.
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|a This volume presents important pharmaceuticals. Each of the around 20 chapters covers in a concise manner one class of heterocycles, clearly structured as follows:* Structural formulas of most important examples (market products)* Short background of history or discovery* Typical syntheses of important examples* Mode of action* Characteristic biological activity* Structure-activity relationship* Additional chemistry information (e.g. further transformations, alternative syntheses, metabolic pathways, etc.)* References. A valuable one-stop reference source for researchers in academia and industr.
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|a Introduction. The significance of heterocycles for pharmaceuticals and agrochemicals / Clemens Lamberth, Jürgen Dinges -- Neurological disorders. Tropane-based alkaloids as muscarinic antagonists for the treatment of asthma, obstructive pulmonary disease, and motion sickness / Michael L Schulte, Craig W Lindsley ; Morphinone-based opioid receptor agonist analgesics / Stephanie M Ng ; Barbituric acid-based GABA(A) receptor modulators for the treatment of sleep disorder and epilepsy and as anesthetics / Ingo Janser, Romy Janser ; Phenothiazine-based dopamine D antagonists for the treatment of schizophrenia / Cristiana A Zaharia ; Arylpiperazine-based 5-HT receptor partial agonists and 5-HT antagonists for the treatment of autism, depression, anxiety, psychosis, and schizophrenia / Irini Akritopoulou-Zanze ; Arylpiperidine-based dopamine D antagonists/5-HT antagonists for the treatment of autism, depression, schizophrenia, and bipolar disorder / Ying Wang ; Dibenzazepine-based sodium channel blockers for the treatment of neuropathic pain / Derek W Nelson -- Cardiovascular diseases. Dihydropyridine-based calcium channel blockers for the treatment of angina pectoris and hypertension / Milan Bruncko ; Tetrazole-based angiotensin II type 1 (AT) antagonists for the treatment of heart failure and congestive hypertension / Edward C Lawson, Brian C Shook, James C Lanter ; Thiazide-based diuretics for the treatment of hypertension and genitourinary disorders / Jürgen Dinges ; Tetrahydropyranone-based HMG-CoA reductase inhibitors for the treatment of arterial hypercholesterolemia / Hongyu Zhao -- Infectious diseases. Adenine-based reverse transcriptase inhibitors as anti-HIV agents / Alastair Donald ; Guanine-based nucleoside analogs as antiviral agents / Maurizio Franzini ; Penicillin and cephalosporin antibiotics / Michael Z Hoemann -- Oncology. Pyrimidine-based kinase inhibitors in cancer chemotherapy / Robert Mah ; Benzyl triazole-based aromatase inhibitors for the treatment of breast cancer / Dawn George, Stacy Van Epps -- Inflammation and gastrointestinal diseases. Acetonide-based glucocorticoids for the treatment of asthma, skin inflammation, and diseases of the eye / Kevin P Cusack, Vikram G Kalthod, Rajarathnam E Reddy, Sanjay R Chemburkar ; Benzimidazole-based H/K-ATPase inhibitors for the treatment of gastroesophageal reflux disease / Steve Swann -- Metabolic diseases. Thiazolidinedione-based insulin sensitizers: PPAR-? agonists for the treatment of type 2 diabetes / Steven Richards -- Index.
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590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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650 |
|
0 |
|a Heterocyclic compounds.
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650 |
|
0 |
|a Pharmaceutical chemistry.
|
650 |
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6 |
|a Composés hétérocycliques.
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650 |
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6 |
|a Chimie pharmaceutique.
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|a SCIENCE
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|x Organic.
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|a Lamberth, Clemens.
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|a Dinges, Jurgen.
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|i has work:
|a Bioactive heterocyclic compound classes Agrochemicals (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCFVdXwffk3dFFFwTVj7Q9C
|4 https://id.oclc.org/worldcat/ontology/hasWork
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|i Print version:
|t Bioactive heterocyclic compound classes.
|d Weinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2012
|z 9783527333950
|w (OCoLC)807249672
|
856 |
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|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=999416
|z Texto completo
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|6 505-00/(S
|a Introduction. The significance of heterocycles for pharmaceuticals and agrochemicals / Clemens Lamberth, Jürgen Dinges -- Neurological disorders. Tropane-based alkaloids as muscarinic antagonists for the treatment of asthma, obstructive pulmonary disease, and motion sickness / Michael L Schulte, Craig W Lindsley ; Morphinone-based opioid receptor agonist analgesics / Stephanie M Ng ; Barbituric acid-based GABA(A) receptor modulators for the treatment of sleep disorder and epilepsy and as anesthetics / Ingo Janser, Romy Janser ; Phenothiazine-based dopamine D antagonists for the treatment of schizophrenia / Cristiana A Zaharia ; Arylpiperazine-based 5-HT receptor partial agonists and 5-HT antagonists for the treatment of autism, depression, anxiety, psychosis, and schizophrenia / Irini Akritopoulou-Zanze ; Arylpiperidine-based dopamine D antagonists/5-HT antagonists for the treatment of autism, depression, schizophrenia, and bipolar disorder / Ying Wang ; Dibenzazepine-based sodium channel blockers for the treatment of neuropathic pain / Derek W Nelson -- Cardiovascular diseases. Dihydropyridine-based calcium channel blockers for the treatment of angina pectoris and hypertension / Milan Bruncko ; Tetrazole-based angiotensin II type 1 (AT) antagonists for the treatment of heart failure and congestive hypertension / Edward C Lawson, Brian C Shook, James C Lanter ; Thiazide-based diuretics for the treatment of hypertension and genitourinary disorders / Jürgen Dinges ; Tetrahydropyranone-based HMG-CoA reductase inhibitors for the treatment of arterial hypercholesterolemia / Hongyu Zhao -- Infectious diseases. Adenine-based reverse transcriptase inhibitors as anti-HIV agents / Alastair Donald ; Guanine-based nucleoside analogs as antiviral agents / Maurizio Franzini ; Penicillin and cephalosporin antibiotics / Michael Z Hoemann -- Oncology. Pyrimidine-based kinase inhibitors in cancer chemotherapy / Robert Mah ; Benzyl triazole-based aromatase inhibitors for the treatment of breast cancer / Dawn George, Stacy Van Epps -- Inflammation and gastrointestinal diseases. Acetonide-based glucocorticoids for the treatment of asthma, skin inflammation, and diseases of the eye / Kevin P Cusack, Vikram G Kalthod, Rajarathnam E Reddy, Sanjay R Chemburkar ; Benzimidazole-based H/K-ATPase inhibitors for the treatment of gastroesophageal reflux disease / Steve Swann -- Metabolic diseases. Thiazolidinedione-based insulin sensitizers: PPAR-γ agonists for the treatment of type 2 diabetes / Steven Richards -- Index.
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