Biopharmaceutics modeling and simulations : theory, practice, methods, and applications /

A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design,...

Description complète

Détails bibliographiques
Cote:Libro Electrónico
Auteur principal: Sugano, Kiyohiko
Format: Électronique eBook
Langue:Inglés
Publié: Hoboken, N.J. : Chichester : Wiley-Blackwell ; John Wiley [distributor], 2012.
Sujets:
Biopharmaceutics.
Computer simulation.
Digital computer simulation.
Pharmacology.
Pharmaceutical technology.
Medical personnel.
Life sciences.
Physical sciences.
Methodology.
Mathematical models.
Computing Methodologies
Pharmacology
Investigative Techniques.
Technology, Pharmaceutical
Analytical, Diagnostic and Therapeutic Techniques and Equipment.
Health Occupations
Information Science
Biological Science Disciplines
Natural Science Disciplines
Disciplines and Occupations.
Methods
Biopharmaceutics
Models, Theoretical
Drug Compounding
Computer Simulation
Health Workforce.
Health Personnel
Biopharmacie.
Simulation par ordinateur.
Pharmacologie.
Techniques pharmaceutiques.
Personnel médical.
Sciences de la vie.
Sciences physiques.
Méthodologie.
Modèles mathématiques.
simulation.
pharmacology.
biological sciences.
physical sciences.
methodology.
mathematical models.
MEDICAL > Pharmacology.
Physical sciences
Pharmaceutical technology
Methodology
Medical personnel
Mathematical models
Life sciences
Digital computer simulation
Computer simulation
Health & Biological Sciences.
Pharmacy, Therapeutics, & Pharmacology.
Accès en ligne:Texto completo
Table des matières:
  • Introduction
  • Theoretical framework I : solubility
  • Theoretical framework II : dissolution
  • Theoretical framework III : biological membrane permeation
  • Theoretical framework IV : gastrointestinal transit models and integration
  • Physiology of gastrointestinal tract and other administration sites in humans and animals
  • Drug parameters
  • Validation of mechanistic models
  • Bioequivalence and biopharmaceutical classification system
  • Dose and particle size dependency
  • Enabling formulations
  • Food effect
  • Biopharmaceutical modeling for miscellaneous cases
  • Intestinal transporters
  • Strategy in drug discovery and development
  • Epistemology of biopharmaceutical modeling and good simulation practice.

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