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049 |a UAMI 
100 1 |a Symposium, CIBA Foundation. 
245 1 0 |a Environmental Chemicals, Enzyme Function and Human Disease. 
260 |a Hoboken :  |b John Wiley & Sons,  |c 2009. 
300 |a 1 online resource (392 pages) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Novartis Foundation Symposia ;  |v v. 868 
588 0 |a Print version record. 
505 0 |a Environmental Chemicals Enzyme Function and Human Disease; Contents; Chairman's introduction; The role of the drug-metabolizing enzymes; Discussion; The influence of inducers on drug-metabolizing enzyme activity and on formation of reactive drug metabolites in the liver; Discussion; Effects of inducers and inhibitors on drug-metabolizing enzymes and on drug toxicity in extrahepatic tissues; Discussion; Induction of enzymes involved in DNA repair and mutagenesis; Discussion. 
505 8 |a Induction of drug-metabolizing enzymes by polycyclic aromatic hydrocarbons: mechanisms, and some implications in environmental health researchDiscussion; Discussion; Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects; Substrate-dependent irreversible inactivation of cytochrome P-450: conversion of its haem moiety into modified porphyrins; Discussion; General Discussion I; Regulation of human drug metabolism by dietary factors; Discussion; Influence of foreign compounds on formation and disposition of reactive metabolites; Discussion. 
505 8 |a Pharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolitesDiscussion; Toxicological implications of polymorphic drug metabolism; Immunologically mediated toxicity; Discussion; Toxicological significance of liver hypertrophy produced by inducers of drug-metabolizing enzymes; Discussion; Discussion; Discussion; The influence of nutrition and inducers on mechanisms of toxicity in humans and animals; Influence of environmental chemicals on drug therapy in humans: studies with contraceptivesteroids; Discussion; General Discussion II. 
505 8 |a Vitamin D metabolism in patients treated with phenytoin and phenobarbitoneDiscussion; Chemical disease in humans: problems in comparative toxicology; Discussion; Implications for future studies in humans; Final General Discussion; Index of Contributors; Subject Index. 
590 |a ProQuest Ebook Central  |b Ebook Central Academic Complete 
650 0 |a Toxicology  |v Congresses. 
650 0 |a Drugs  |x Metabolism  |v Congresses. 
650 0 |a Enzyme induction  |v Congresses. 
650 0 |a Biotransformation (Metabolism)  |v Congresses. 
650 6 |a Toxicologie  |v Congrès. 
650 6 |a Médicaments  |x Métabolisme  |v Congrès. 
650 6 |a Induction enzymatique  |v Congrès. 
650 6 |a Biotransformation (Métabolisme)  |v Congrès. 
650 7 |a Biotransformation (Metabolism)  |2 fast 
650 7 |a Drugs  |x Metabolism  |2 fast 
650 7 |a Enzyme induction  |2 fast 
650 7 |a Toxicology  |2 fast 
655 7 |a Conference papers and proceedings  |2 fast 
776 0 8 |i Print version:  |a Symposium, CIBA Foundation.  |t Environmental Chemicals, Enzyme Function and Human Disease.  |d Hoboken : John Wiley & Sons, ©2009  |z 9780470663875 
830 0 |a Novartis Foundation Symposia. 
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