Case studies in modern drug discovery and development /

"Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples....

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Huang, Xianhai, Aslanian, Robert G.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Oxford : Hoboken, N.J. : Wiley-Blackwell ; John Wiley & Sons, 2012.
Temas:
Drug development > Case studies.
Drugs > Design > Case studies.
Pharmaceutical chemistry > Case studies.
Pharmaceutical chemistry.
Pharmacology.
Chemistry.
Life sciences.
Physical sciences.
Chemistry, Pharmaceutical
Investigative Techniques
Evaluation Studies as Topic
Pharmacology
Chemistry
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Biological Science Disciplines
Natural Science Disciplines
Disciplines and Occupations
Drug Discovery
Drug Evaluation
Health & Biological Sciences.
Pharmacy, Therapeutics, & Pharmacology.
Médicaments > Développement > Études de cas.
Médicaments > Conception > Études de cas.
Chimie pharmaceutique > Études de cas.
Chimie pharmaceutique.
Pharmacologie.
Chimie.
Sciences de la vie.
Sciences physiques.
pharmacology.
chemistry.
biological sciences.
physical sciences.
MEDICAL > Drug Guides.
MEDICAL > Nursing > Pharmacology.
MEDICAL > Pharmacology.
MEDICAL > Pharmacy.
Physical sciences
Life sciences
Drug development
Drugs > Design
Pharmaceutical chemistry
Case studies
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Introduction: drug discovery in difficult times / Malcom MacCoss
  • Discovery and development of the DPP-4 inhibitor JANUVIA (Sita-gliptin) / Emma R. Parmee [and others]
  • Olmesartan medoxomil, an angiotensin II receptor blocker / Hiroaki Yanagisawa, Hiroyuki Koike, and Shini-chiro Miura
  • Discovery of heterocyclic phosphonic acids as novel AMP mimics that are potent and selective fructose-1,6-bisphosphatase inhibitors and elicit potent glucose-lowering effects in diabetic animals and humans / Qun Dang and Mark D. Erion
  • Setting the paradigm of targeted drugs for the treatment of cancer : Imatinib and Nilotinib, therapies for chronic myelogenous leukemia / Paul W. Manley and Jürg Zimmermann
  • Amrubicin, a completely synthetic 9-aminoanthracycline for extensive-disease small-cell lung cancer / Mitsuharu Hanada
  • The discovery of dual IGF-1R and IR inhibitor FQIT for the treatment of cancer / Meizhong Jin, Elizabeth Buck, and Mark J. Mulvihill
  • Discovery and development of Montelukast (Singulair) / Robert N. Young
  • Discovery and development of Maraviroc, a CCR5 antagonist for the treatment of HIV infection / Patrick Dorr, Blanda Stammen, Elna van der Ryst
  • Discovery of antimalarial drug Artemisinin and beyond / Weiwei Mao, Yu Zhang, and Ao Zhang
  • Discovery and process development of MK-4965, a potent nonnucleoside reverse transcriptase inhibitor / Yong-Li Zhong, Thomas J. Tucker, and Jingjun Yin
  • Discovery of Boceprevir and Narlaprevir : the first and second generation of HCV NS3 protease inhibitors / Kevin X. Chen and F. George Njoroge
  • The discovery of Samsca (Tolvaptan) : the first oral nonpeptide vasopressin receptor antagonist / Kazumi Kondo and Yoshitaka Yamamura
  • SILODOSIN (Urief, Rapaflo, Thrupas, Urorec, Silodix) : a selective à1A adrenoceptor antagonist for the treatment of benign prostatic hyperplasia / Masaki Yoshida [and others]
  • Raloxifene : a selective estrogen receptor modulator (SERM) / Jeffrey A. Dodge and Henry U. Bryant.

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