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Parasitic helminths : targets, screens, drugs, and vaccines /
This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals. The result is a broad overview of different drug target evaluation methods, including specific examples of successful d...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken :
John Wiley & Sons,
2012.
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| Colección: | Drug discovery in infectious diseases.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Parasitic helminths : |b targets, screens, drugs, and vaccines / |c edited by Conor R. Caffrey. |
| 260 | |a Hoboken : |b John Wiley & Sons, |c 2012. | ||
| 300 | |a 1 online resource (542 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Drug Discovery in Infectious Diseases | |
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Parasitic Helminths: Targets, Screens, Drugs and Vaccines; Foreword to Parasitic Helminths: Targets, Screens, Drugs and Vaccines; Contents; Preface; List of Contributors; Part One: Targets; 1 Ligand-Gated Ion Channels as Targets for Anthelmintic Drugs: Past, Current, and Future Perspectives; Introduction; Established LGIC Anthelmintic Drug Targets; GluCls -- Targets for Ivermectin; L-Type nAChRs -Targets for Levamisole, Pyrantel, Morantel, and Tribendimidine; nAChRs (DEG-3 Group) -- Targets for AADs; GABA-Gated Chloride Channels -- Targets for Piperazine. | |
| 505 | 8 | |a Evaluating Possible Anthelmintic Targets for the FutureN-Type nAChRs; Nematode-Specific nAChRs and Orphan nAChR-Like Subunits; GABA Receptor Cation Channels; 5-HT Channels; ACh Chloride Channels; GGR-1 Group; GGR-3 Group; LGC-45 Group; Ungrouped Subunits; Cys-Loop LGIC Superfamilies of Other Nematodes; Genomics; Chemistry-to-Gene Screens to Identify New Targets; First Crystal Structure of a Cys-Loop LGIC Complexed with a Commercial Animal Health Drug; Conclusions and Future Lines of Research; References. | |
| 505 | 8 | |a 2 How Relevant is Caenorhabditis elegans as a Model for the Analysis of Parasitic Nematode Biology?; Introduction; Comparative Genome Analysis for the Phylum Nematoda; Functional Characterization of Parasite Genes by Heterologous Expression in C. elegans; Comparative Pharmacology of C. elegans and Parasitic Nematode Neurotransmitter Receptors; C. elegans as a Tool to Understand the Mode of Action of Novel Anthelmintics; C. elegans as a Platform for Target Discovery; Conclusions; References; 3 Integrating and Mining Helminth Genomes to Discover and Prioritize Novel Therapeutic Targets. | |
| 505 | 8 | |a Introduction; Availability of Genome Sequence Information for Parasitic Helminths; Overview of Genome Annotation Datasets that Aid Target Identification; Orthology-Based Annotations and Comparative Genomics; Predictions of Essentiality; Orthology-Based RNAi Phenotype Data Mapping Between C. elegans and Parasitic Helminths; The TDR Targets Database; Target Prioritization in B. malayi and S. mansoni Using the TDR Targets Database; Currently Unavailable Genomic Datasets that will Improve Target Prioritization for Parasitic Helminths; Conclusions; Acknowledgments; References. | |
| 505 | 8 | |a 4 Recent Progress in Transcriptomics of Key Gastrointestinal Nematodes of Animals -- Fundamental Research Toward New Intervention Strategies; Introduction; Recent Developments in the Bioinformatic Tools and Pipelines for the Analysis of Expressed Sequence Tag Data; Characterizing the Transcriptomes of Strongylid Nematodes; Conclusions and Prospects; Acknowledgments; References; 5 Harnessing Genomic Technologies to Explore the Molecular Biology of Liver Flukes-Major Implications for Fundamental and Applied Research; Introduction. | |
| 520 | |a This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals. The result is a broad overview of different drug target evaluation methods, including specific examples of successful drug development against helminthes, and with a whole section devoted to vaccine development. With its well-balanced mix of high-profile contributors from academia and industry, this handbook and reference will appeal to a wide audience, including parasitologists, pharmaceutical industry, epidemiologists, and. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Anthelmintics |x Development. | |
| 650 | 0 | |a Helminthiasis |x Chemotherapy. | |
| 650 | 6 | |a Anthelminthiques |x Développement. | |
| 650 | 6 | |a Helminthiase |x Chimiothérapie. | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a Helminthiasis |x Chemotherapy |2 fast | |
| 700 | 1 | |a Caffrey, Conor R. | |
| 700 | 1 | |a Selzer, P. M. |q (Paul M.) |1 https://id.oclc.org/worldcat/entity/E39PCjyRPY3YdH4d8Qt86J8P33 | |
| 758 | |i has work: |a Parasitic helminths (Text) |1 https://id.oclc.org/worldcat/entity/E39PCFB8Xcbfh3Vjy7TwVcpF8C |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |a Caffrey, Conor R. |t Parasitic Helminths. |d Hoboken : John Wiley & Sons, ©2012 |z 9783527330591 |
| 830 | 0 | |a Drug discovery in infectious diseases. | |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=945185 |z Texto completo |
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