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Vaccinology : Principles and Practice.
Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requir...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken :
John Wiley & Sons,
2012.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Vaccinology: Principles and Practice; Contents; List of Contributors; Preface; PART 1 Introduction; CHAPTER 1 Concept and Scope of Modern Vaccines; Introduction; Triumphs and limitations of current vaccination; Modern approaches that impact vaccine design; Genomics; Improved delivery systems and adjuvants; Therapeutic vaccination; A return to attenuated organisms?; Improve existing vaccines and vaccine uptake; Hurdles and challenges for the future; Non-infectious diseases as targets for modern vaccines; Transition from research to trial; References; PART 2 Principles of Vaccine Design.
- CHAPTER 2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine AdjuvantsPrinciples of vaccine design: stimulation of innate immunity; Innate immune stimulators; Toll-like receptors; Non-Toll-like receptors; Practical applications for adjuvants; Action; Safety; Summary; Acknowledgements; References; CHAPTER 3 Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules; MHC class I and II structure; Structural composition; The peptide-binding grooves; Nonclassical MHC class I molecules; MHC molecule assembly.
- Pre-peptide loading complex stage of MHC class I foldingThe peptide-loading complex and export to the cell surface; MHC class II molecules and the invariant chain; The MHC class II peptide loading complex; Peptide generation; Peptide generation in the MHC class I pathway; Peptide generation in the MHC class II pathway; Cross- and criss-cross presentation; Summary; Acknowledgments; References; CHAPTER 4 Understanding the Mucosal Immune System for Better Mucosal Vaccine Design; Introduction; Anatomy of the mucosal immune system; Players of the mucosal immune system; Mucosal epithelium.
- Mucosal-associated lymphoreticular tissueMucosal draining lymph nodes; Lamina propria; Mucosal vaccines: current strategies and ongoing challenges; Mucosal vaccines for human use; Final word; References; CHAPTER 5 Immunologic Memory: T Cells in Humans; Introduction; Generation of memory T cells; Different types of memory T cells in humans; Parameters influencing the induction of a T-cell response; Induction of T-cell memory with a vaccine; Major obstacles; Manipulating the immune response with a vaccine; Examples of vaccine-induced memory T-cell responses; Concluding remarks; Acknowledgments.