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Pharmaceutical Dosage Forms - Tablets : Rational Design and Formulation.
Pharmaceutical Dosage Forms: Tablets, Third Editionis acomprehensive treatment of the design, formulation, manufacture, and evaluation of the tablet dosage form. The ultimate goal of drug product development is to design a system that maximizes the therapeutic potential of the drug substance and fac...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Informa Healthcare,
2008.
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| Edición: | 3rd ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover Page; Pharmaceutical Dosage Forms: Tablets; Copyright Page; Preface; Contents; INTRODUCTION; MATERIAL PROPERTIES; SYSTEMS AND BALANCES; MOTION IN MIXTURES; EFFECT OF A MATRIX; SUMMARY; LIST OF SYMBOLS; REFERENCES; 1 Mass Transfer from Solid Oral Dosage Forms; INTRODUCTION; PHYSICAL MODIFICATIONS-PARTICLE SIZE REDUCTION; SALT FORMATION; CO-CRYSTAL FORMATION; COMPLEXATION USING CYCLODEXTRIN; MODIFICATION OF CRYSTAL; LIPID-BASED FORMULATION; PRODRUG FORMATION; SUMMARY; REFERENCES; 2 Approaches for Improving Bioavailability of Poorly Soluble Drugs; BASIC STATISTICAL CONSIDERATIONS.
- FACTORIAL DESIGNRESPONSE SURFACE METHODOLOGY; MATHEMATICAL OPTIMIZATION; REFERENCES; 3 Aims and Objectives and of Experimental Design and Optimization in Formulation and Process Development; INTRODUCTION AND THE SCOPE OF THE CHAPTER; KNOWLEDGE-BASED SYSTEMS; NEURAL NETWORKS AND NEURAL COMPUTING; OTHER MODELS FOR INTELLIGENT SYSTEMS; SOME PRACTICAL APPLICATIONS IN PRODUCT AND PROCESS DEVELOPMENT; THE FUTURE; REFERENCES; 4 Knowledge-based Systems and Other AI Applications for Tableting; INTRODUCTION; THE DC PROCESS; DC FORMULATION; DC BINDERS AND FILLERS; INORGANIC CALCIUM SALTS.
- COPROCESSED ACTIVE INGREDIENTSFUTURE OF DC TABLETING; APPENDIX 1; APPENDIX 2: DIRECTORY OF TRADE NAMES OF COMMON DC EXCIPIENTS; REFERENCES; 5 Direct Compression and the Role of Filler-binders; INTRODUCTION; A GENERAL STRUCTURE AND FORM FOR TABLET DISINTEGRANTS; POSSIBLE MECHANISMS OF TABLET DISINTEGRATION; INFLUENCE OF PHARMACEUTICAL PROCESSING ON DISINTEGRANTS; INTERACTIONS WITH OTHER FORMULATION COMPONENTS; USE AND INCORPORATION OF DISINTEGRANTS IN TABLET FORMULATIONS; REVIEW OF TABLET DISINTEGRANTS; METHODS FOR THE EVALUATION OF TABLET DISINTEGRANTS.
- METHODS FOR THE EVALUATION OF TABLET DISINTEGRATIONCONCLUSION; REFERENCES; 6 Disintegrants in Tableting; INTRODUCTION; LUBRICANTS; ANTIADHERENTS; GLIDANTS; REFERENCES; 7 Lubricants, Glidants, and Antiadherents; INTRODUCTION; SURFACTANTS; COLORING; CONCLUSION; REFERENCES; 8 Surfactants and Colors in Tablets; INTRODUCTION; FORMULATION CONSIDERATIONS OF ORALLY DISINTEGRATING TABLETS; TECHNOLOGIES FOR MANUFACTURING ORALLY DISINTEGRATING TABLETS; CHOICE OF EXCIPIENTS; DISINTEGRATING AGENTS; SWEETENERS; MEASUREMENT OF TASTE; MEASUREMENT OF DISINTEGRATION TIME; OTHER TABLET FORMULATIONS; SUMMARY.