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Microwaves in organic and medicinal chemistry.
Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with an additional volume. As in the predecessor, a short introductory section covers the theoretical backg...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | , , , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken :
John Wiley & Sons,
2012.
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| Edición: | 2nd ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Microwaves in Organic and Medicinal Chemistry; Contents; Preface; Personal Foreword to the First Edition; Personal Foreword to the Second Edition; 1 Introduction: Microwave Synthesis in Perspective; 1.1 Microwave Synthesis and Medicinal Chemistry; 1.2 Microwave-Assisted Organic Synthesis (MAOS): A Brief History; 1.3 Scope and Organization of the Book; References; 2 Microwave Theory; 2.1 Microwave Radiation; 2.2 Microwave Dielectric Heating; 2.3 Dielectric Properties; 2.4 Microwave versus Conventional Thermal Heating; 2.5 Microwave Effects; 2.5.1 Temperature Monitoring in Microwave Chemistry.
- 2.5.2 Thermal Effects (Kinetics)2.5.3 Specific Microwave Effects; 2.5.4 Nonthermal (Athermal) Microwave Effects; References; 3 Equipment Review; 3.1 Introduction; 3.2 Domestic Microwave Ovens; 3.3 Dedicated Microwave Reactors for Organic Synthesis; 3.4 Single-Mode Instruments; 3.4.1 Anton Paar GmbH; 3.4.1.1 Monowave 300; 3.4.2 Biotage AB; 3.4.2.1 Initiator Platform; 3.4.2.2 Chemspeed SWAVE; 3.4.2.3 Peptide Synthesizers; 3.4.3 CEM Corporation; 3.4.3.1 Discover Platform; 3.4.3.2 Explorer Systems; 3.4.3.3 Voyager System; 3.4.3.4 Peptide Synthesizers; 3.5 Multimode Instruments.
- 3.5.1 Anton Paar GmbH3.5.1.1 Synthos 3000; 3.5.1.2 Masterwave Benchtop Reactor; 3.5.2 Biotage AB; 3.5.3 CEM Corporation; 3.5.3.1 MARS Scale-Up System Accessories; 3.5.3.2 MARS Parallel System Accessories; 3.5.4 Milestone s.r.l; 3.5.4.1 MultiSYNTH System; 3.5.4.2 MicroSYNTH Labstation; 3.5.4.3 StartSYNTH; 3.5.4.4 Scale-Up Systems; 3.5.4.5 Microwave-Heated Autoclave Systems; References; 4 Microwave Processing Techniques; 4.1 Solvent-Free Reactions; 4.2 Phase-Transfer Catalysis; 4.3 Open- versus Closed-Vessel Conditions; 4.4 Pre-pressurized Reaction Vessels; 4.5 Nonclassical Solvents.
- 4.5.1 Water as Solvent4.5.2 Ionic Liquids; 4.6 Passive Heating Elements; 4.7 Processing Techniques in Drug Discovery and High-Throughput Synthesis; 4.7.1 Automated Sequential versus Parallel Processing; 4.7.2 High-Throughput Synthesis Methods; 4.7.2.1 Solid-Phase Synthesis; 4.7.2.2 Soluble Polymer-Supported Synthesis; 4.7.2.3 Fluorous-Phase Organic Synthesis; 4.7.2.4 Polymer-Supported Reagents, Catalysts, and Scavengers; 4.8 Scale-Up in Batch and Continuous Flow; 4.8.1 Scale-Up in Batch and Parallel; 4.8.2 Scale-Up Using Continuous Flow Techniques; 4.8.3 Scale-Up Using Stop-Flow Techniques.
- 4.8.4 Microwave Reactor Systems for Production ScaleReferences; 5 Literature Survey Part A: Transition Metal-Catalyzed Reactions; 5.1 General Comments; 5.2 Carbon-Carbon Bond Formations; 5.2.1 Heck Reactions; 5.2.2 Suzuki-Miyaura Reactions; 5.2.3 Sonogashira Reactions; 5.2.4 Stille Reactions; 5.2.5 Negishi, Kumada, and Related Reactions; 5.2.6 Carbonylation Reactions; 5.2.7 Asymmetric Allylic Alkylations; 5.2.8 Miscellaneous Carbon-Carbon Bond-Forming Reactions; 5.3 Carbon-Heteroatom Bond Formations; 5.3.1 Buchwald-Hartwig Reactions; 5.3.2 Ullmann Condensation Reactions.
- 5.3.3 Miscellaneous Carbon-Heteroatom Bond-Forming Reactions.