Cargando…

NMR of Biomolecules.

NMR is one of the most powerful methods for imaging of biomolecules. This book is the ultimate NMR guide for researchers in the biomedical community and gives not only background and practical tips but also a forward looking view on the future of NMR in systems biology.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Bertini, Ivano
Otros Autores: McGreevy, Kathleen S., Parigi, Giacomo
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken : John Wiley & Sons, 2012.
Temas:
Acceso en línea:Texto completo

MARC

LEADER 00000cam a2200000Mu 4500
001 EBOOKCENTRAL_ocn784885263
003 OCoLC
005 20240329122006.0
006 m o d
007 cr |n|---|||||
008 120409s2012 xx o 000 0 eng d
040 |a EBLCP  |b eng  |e pn  |c EBLCP  |d OCLCQ  |d YDXCP  |d OCLCQ  |d DEBSZ  |d IDEBK  |d DEBBG  |d OCLCQ  |d ZCU  |d OCLCQ  |d MERUC  |d ICG  |d OCLCO  |d OCLCF  |d AU@  |d OCLCQ  |d DKC  |d OCLCQ  |d OCLCO  |d OCLCQ  |d OCLCO 
019 |a 813397903  |a 813534728  |a 817822717 
020 |a 9783527644513 
020 |a 3527644512 
029 1 |a AU@  |b 000055805454 
029 1 |a DEBBG  |b BV041900829 
029 1 |a DEBBG  |b BV044049757 
029 1 |a DEBSZ  |b 43110591X 
029 1 |a DEBSZ  |b 449290484 
035 |a (OCoLC)784885263  |z (OCoLC)813397903  |z (OCoLC)813534728  |z (OCoLC)817822717 
050 4 |a QV744 
060 4 |a 2012 F-296 
060 4 |a QU 25 190 
082 0 4 |a 572  |a 615.9 
049 |a UAMI 
100 1 |a Bertini, Ivano. 
245 1 0 |a NMR of Biomolecules. 
260 |a Hoboken :  |b John Wiley & Sons,  |c 2012. 
300 |a 1 online resource (1746 pages) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
505 0 |a Cover; Related Titles; Title Page; Copyright; Preface; List of Contributors; List of Abbreviations; Part One: Introduction; Chapter 1: NMR and its Place in Mechanistic Systems Biology; Chapter 2: Structure of Biomolecules: Fundamentals; 2.1 Structural Features of Proteins; 2.2 Nucleic Acids; Chapter 3: What Can be Learned About the Structure and Dynamics of Biomolecules from NMR; 3.1 Proteins Studied by NMR; 3.2 Nucleic Acids Studied by NMR; Part Two: Role of NMR in the Study of the Structure and Dynamics of Biomolecules; Chapter 4: Determination of Protein Structure and Dynamics. 
505 8 |a 4.1 Determination of Protein Structures4.2 NMR Restraints; 4.3 Structure Calculations; 4.5 Protein Dynamics and NMR Observables; 4.6 Protocols; 4.7 Troubleshooting; Further Reading; Chapter 5: DNA; 5.1 NMR studies of DNA; 5.2 Assessment of the Folding Topology; 5.3 Resonance Assignment through Sequential and Interstrand Interactions; 5.4 Pseudorotation of Deoxyribofuranose Rings; 5.5 Backbone Conformation; 5.6 Natural Abundance Nucleobase Substitutions; 5.7 Natural Abundance Heteronuclear Experiments; 5.8 Site-Specific Low Isotopic Enrichment; 5.9 Translational Diffusion Coefficients. 
505 8 |a 5.10 Determination of Three-Dimensional Structure5.11 Search for Transient Structures; 5.12 Protocols; 5.13 Example Experiments and Troubleshooting; Acknowledgments; Further Reading; Chapter 6: RNA; 6.1 NMR Spectroscopy of RNA; 6.2 Preparation of RNA Samples for NMR; 6.3 Probing of the RNA Fold; 6.4 Assessment of the Spectral Resolution; 6.5 Strategy for the Resonance Assignment; 6.6 Collection of Structural Information; 6.7 Structural Calculation of RNA; 6.8 Assessment of Quality of NMR Structures; 6.9 Protocols; 6.10 Troubleshooting; Acknowledgments; Further Reading. 
505 8 |a Chapter 7: Intrinsically Disordered Proteins7.1 Intrinsically Disordered Proteins; 7.2 Importance of NMR to Study IDPs; 7.3 Structural and Dynamic Information on IDPs -- NMR Observables; 7.4 Protocols; 7.5 Troubleshooting; Further Reading; Chapter 8: Paramagnetic Molecules; 8.1 Paramagnetism-Assisted NMR; 8.2 Scalar and Dipolar Electron Spin-Nuclear Spin Interactions: Hyperfine Shift; 8.3 Scalar and Dipolar Electron Spin-Nuclear Spin Interactions: PRE; 8.4 Indirect Electron Spin-Nuclear Spin Effects: Paramagnetism-Induced RDCs; 8.5 Cross-Correlation Between Curie and Dipolar Relaxation. 
505 8 |a 8.6 "Good" Metal Ions and "Bad" Metal Ions8.7 Paramagnetism-Based Drug Discovery; 8.8 Protocols; 8.9 Troubleshooting; Further Reading; Part Three: Role of NMR in the Study of the Structure and Dynamicsof Biomolecular Interactions; Chapter 9: NMR Methodologies for the Analysis of Protein-Protein Interactions; 9.1 Introduction; 9.2 Dynamics and Ligand Binding; 9.3 General Strategy; 9.4 Overview of Methods; 9.5 Outlook; 9.6 Protocols for the Analysis of Protein Complexes; 9.7 Troubleshooting; Further Reading; Chapter 10: Metal-Mediated Interactions; 10.1 Theoretical Background. 
500 |a 10.2 Protocol for the Structural Determination of a Metal-Mediated Complex. 
588 0 |a Print version record. 
520 |a NMR is one of the most powerful methods for imaging of biomolecules. This book is the ultimate NMR guide for researchers in the biomedical community and gives not only background and practical tips but also a forward looking view on the future of NMR in systems biology. 
590 |a ProQuest Ebook Central  |b Ebook Central Academic Complete 
650 0 |a Biomolecules. 
650 0 |a Biological systems. 
650 0 |a Nuclear magnetic resonance spectroscopy. 
650 0 |a Systems biology. 
650 2 |a Magnetic Resonance Spectroscopy 
650 2 |a Systems Biology 
650 6 |a Biomolécules. 
650 6 |a Systèmes biologiques. 
650 6 |a Spectroscopie de la résonance magnétique nucléaire. 
650 6 |a Biologie systémique. 
650 7 |a Biological systems  |2 fast 
650 7 |a Biomolecules  |2 fast 
650 7 |a Nuclear magnetic resonance spectroscopy  |2 fast 
650 7 |a Systems biology  |2 fast 
700 1 |a McGreevy, Kathleen S. 
700 1 |a Parigi, Giacomo. 
776 0 8 |i Print version:  |a Bertini, Ivano.  |t NMR of Biomolecules.  |d Hoboken : John Wiley & Sons, ©2012  |z 9783527328505 
856 4 0 |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=871260  |z Texto completo 
938 |a EBL - Ebook Library  |b EBLB  |n EBL871260 
938 |a ProQuest MyiLibrary Digital eBook Collection  |b IDEB  |n 395653 
938 |a YBP Library Services  |b YANK  |n 7598384 
938 |a YBP Library Services  |b YANK  |n 7581253 
994 |a 92  |b IZTAP