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Therapeutic Proteins : Strategies to Modulate Their Plasma Half-life.
For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Weinheim :
John Wiley & Sons,
2011.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Therapeutic Proteins: Strategies to Modulate Their Plasma Half-Lives; Contents; Preface; List of Contributors; Part One: General Information; 1: Half-Life Modulating Strategies
- An Introduction; 1.1 Therapeutic Proteins; 1.2 Renal Clearance and FcRn-Mediated Recycling; 1.3 Strategies to Modulate Plasma Half-Life; 1.3.1 Strategies to Increase the Hydrodynamic Radius; 1.3.2 Strategies Implementing FcRn-Mediated Recycling; 1.4 Half-Life Extension Strategies Applied to a Bispecific Single-Chain Diabody
- A Case Study; 1.5 Conclusion; References.