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Heme Biology : the Secret Life of Heme in Regulating Diverse Biological Processes /
This invaluable book provides the first description of the diverse and fascinating functions of heme in life processes for a broad audience. It begins with an introduction to the intricate chemical properties of heme and the history of early observations of human diseases associated with heme. It th...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Singapore :
World Scientific,
©2011.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Bach1: A heme-dependent transcriptional regulator in mammalian cellsBach1, like Hap1, binds to heme via HRMs; Heme affects Bach1 at three levels; Perspectives; References; Chapter 4 Heme-Regulated eIF2[alpha] Kinase in Translation and Erythropoiesis Jane-Jane Chen and Rajasekhar NVS Suragani; Overview; Introduction; HRI is responsible for heme-regulated translation in erythroid precursors; Phosphorylation of eIF2[alpha] under diverse cellular stresses by the family of eIF2[alpha] kinases; Activation of HRI by autophosphorylation; Inhibition of HRI activity by heme.
- Preface; List of Contributors; Chapter 1 Introduction Li Zhang; Overview; References; Chapter 2 Heme Biosynthesis and Degradation: What Happens when it goes Haywire? Li Zhang and Rebekah Sessoms; Overview; Heme is synthesized by the actions of eight enzymes in humans; Heme biosynthesis is regulated according to the needs for heme in human cells; Defective heme biosynthesis causes serious diseases in humans; Heme is degraded continuously in the human body; Defects in heme degradation can cause serious diseases; References.
- Chapter 3 Heme: An Ingenious Regulator of Gene Transcription Li ZhangOverview; Heme can control the activity of diverse transcriptional regulators; Heme serves as a secondary messenger of oxygen in yeast; Heme can control the expression of a high number of genes in yeast; The heme activator protein Hap1 is a key regulator of gene transcription in response to fluctuations in oxygen and heme levels; Heme regulation of Hap1 transcription-activating activity requires the proper functioning of Hsp90 and Hsp70 molecular chaperones.
- Two distinct heme-binding domains in the cooperation of heme-regulation of HRITissue expression and phylogenetic conservation of HRI; Coordination of heme and globin synthesis by HRI; Regulation of erythroid differentiation by HRI; Integrated stress response of eIF2[alpha]P signaling; Concluding remarks; Acknowledgement; References; Chapter 5 Role of Heme in Brain Functions: Dr. Jekyll or Mr. Hyde? Tatyana Chernova and Andrew G. Smith; Overview; Heme synthesis and disturbances pertinent to neuronal cells; Contradictory roles of heme as a toxic and a physiological molecule.
- Neurotoxic effects of hemeAcute damage; Chronic damage; Neuroglobin, hemoglobin and their neuroprotective roles; Heme oxygenases and neurodegenerative diseases: Where does heme come from?; Emerging regulatory roles for heme in neurons; Neurotrophic effects of heme; Heme can act as a gas-sensing regulator of brain functions; Heme and brain aging: Role of heme for protection from drug-induced neurotoxicity; May sufficient availability of heme delay aging?; Deficiency of heme and Alzheimer's disease; Heme in circadian pathways; References; Chapter 6 Heme and microRNA Biogenesis Feng Guo.