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Molecular machines /
Molecular machines are complex biomolecules, proteins, nucleic acids, and carbohydrates that consume energy in order to perform specific functions. The concerted action of all those machines underlies all the activities of the living cell. To understand how such molecular machines are able to perfor...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Singapore ; Hackensack, NJ :
World Scientific,
©2011.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Molecular machines / |c editor, Benoît Roux. |
| 260 | |a Singapore ; |a Hackensack, NJ : |b World Scientific, |c ©2011. | ||
| 300 | |a 1 online resource (xii, 275 pages) : |b illustrations (some color) | ||
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| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a Molecular machines are complex biomolecules, proteins, nucleic acids, and carbohydrates that consume energy in order to perform specific functions. The concerted action of all those machines underlies all the activities of the living cell. To understand how such molecular machines are able to perform their function, it is necessary to identify the different moving parts and understand how they act together. Breaking new ground with these difficult problems is likely to require novel paradigms permitting a seamless integration of structural, dynamical and functional data from experiments and theory. The goal of this volume is to provide an introduction to the world of biological molecular machines to a broad audience of students and researchers in biosciences. Each chapter is written by leading experts to cover results from cutting-edge research, while remaining broadly accessible. The volume presents the current state of knowledge for several important systems, ranging from polymerases, the ribosome, chaperonins, the chromatophore, kinases, actin and myosin, membrane transporters, and voltage-gated ion channels, thus giving students and researches in biosciences a pedagogically integrated picture of this exciting and rapidly expanding field. | ||
| 505 | 0 | 0 | |t Molecular behavior in biological cells: the bacterial cytoplasm as a model system -- |t The Light-harvesting apparatus in purple photosynthetic bacteria: introduction to a quantum biological device -- |t DNA polymerases: structure, function, and modeling -- |t Information processing by nanomachines: decoding by the ribosome -- |t Chaperonins: the machines which fold proteins -- |t Muscle and myosin -- |t Protein kinases: phosphorylation machines -- |t Computational studies of Na+/H+ antiporter: structure, dynamics and function -- |t Membrane transporters: molecular machines coupling cellular energy to vectorial transport across the membrane -- |t ABC transporters -- |t Sodium-coupled secondary transporters: insights from structure-based computations -- |t Voltage-gated ion channels: the machines responsible for the nerve impulse -- |t Voltage-gated channels and the heart. |
| 590 | |a eBooks on EBSCOhost |b EBSCO eBook Subscription Academic Collection - Worldwide | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Molecular biology. | |
| 650 | 0 | |a Bioenergetics. | |
| 650 | 0 | |a Biomolecules. | |
| 650 | 0 | |a Cell interaction. | |
| 650 | 0 | |a Cytology. | |
| 650 | 0 | |a Microbiology. | |
| 650 | 0 | |a Molecular structure. | |
| 650 | 1 | 2 | |a Molecular Structure |
| 650 | 2 | 2 | |a Models, Molecular |
| 650 | 2 | 2 | |a Cell Communication |
| 650 | 2 | |a Molecular Biology | |
| 650 | 2 | |a Cell Biology | |
| 650 | 2 | |a Microbiology | |
| 650 | 2 | |a Cytology | |
| 650 | 6 | |a Biologie moléculaire. | |
| 650 | 6 | |a Bioénergétique. | |
| 650 | 6 | |a Biomolécules. | |
| 650 | 6 | |a Cellules |x Interaction. | |
| 650 | 6 | |a Cytologie. | |
| 650 | 6 | |a Microbiologie. | |
| 650 | 6 | |a Structure moléculaire. | |
| 650 | 7 | |a molecular biology. |2 aat | |
| 650 | 7 | |a microbiology. |2 aat | |
| 650 | 7 | |a molecular structure. |2 aat | |
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| 650 | 7 | |a Bioenergetics |2 fast | |
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| 650 | 7 | |a Cell interaction |2 fast | |
| 650 | 7 | |a Cytology |2 fast | |
| 650 | 7 | |a Microbiology |2 fast | |
| 650 | 7 | |a Molecular biology |2 fast | |
| 700 | 1 | |a Roux, Benoît, |d 1958- |1 https://id.oclc.org/worldcat/entity/E39PCjMpQbc9FkbQRQkhFrfF83 | |
| 758 | |i has work: |a Molecular machines (Text) |1 https://id.oclc.org/worldcat/entity/E39PCGmtcHbBFmrWkxdvyv6KYd |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |t Molecular machines. |d Singapore ; Hackensack, NJ : World Scientific, ©2011 |z 9789814343442 |w (OCoLC)765783309 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=840683 |z Texto completo |
| 880 | 0 | |6 505-00/(S |a Contents -- Preface -- About the Authors -- Chapter 1 Molecular Behavior in Biological Cells: The Bacterial Cytoplasm as a Model System Adrian H. Elcock and Andrew S. Thomas -- 1. Introduction -- 2. A Simple Analogy for Molecular Behavior in vivo -- 3. Macromolecular Crowding Effects -- 4. The Bacterial Cytoplasm as a Model System -- 5. A Structural Model of the Bacterial Cytoplasm -- 6. Some Issues in Simulating Such a System -- 7. A Dynamic Model of the Bacterial Cytoplasm -- 8. Quantifying Protein Diffusion in the Bacterial Cytoplasm -- 9. Thermodynamic Stability of Proteins in the Bacterial Cytoplasm -- 10. Conclusion -- Acknowledgments -- Suggested Additional Reading Material -- References -- Chapter 2 The Light-Harvesting Apparatus in Purple Photosynthetic Bacteria: Introduction to a Quantum Biological Device Johan Strümpfer, Jen Hsin, Melih Şener, Danielle Chandler and Klaus Schulten -- 1. Introduction -- 2. Components of a Chromatophore Vesicle -- 2.1 The light-harvesting complex LH2 -- 2.2 The RC-LH1 core complex -- 2.2.1 Organization of RC-LH1 -- 2.2.2 Structures of LH1 and RC -- 2.3 Spatial organization of the chromatophore -- 3. Energy Harvesting and Transfer -- 3.1 Excitons -- 3.2 Excitation transfer -- 3.3 Chromatophore-wide exciton transfer -- 4. Discussion -- Acknowledgments -- References -- Appendix -- Chapter 3 DNA Polymerases: Structure, Function, and Modeling Tamar Schlick -- 1. Introduction -- 1.1 Venerable task -- 1.2 Replication and repair fidelity -- 1.3 Polymerase structure and function -- 2. Modeling Studies -- 2.1 Need for modeling -- 2.2 Conformational pathways in pol β, pol λ, pol X, and pol µ -- 2.3 Pol β's closing pathway -- 2.4 Pol β's chemical mechanism for G:C vs. G:A systems -- 2.5 Pol λ's pathway and slippage tendency -- 2.6 Dpo4's handling of 8-oxoG -- 2.7 Pol X mispair incorporation -- 3. Conclusion. | |
| 880 | 8 | |6 505-00/(S |a 5.2 Results from elastic network models -- 6. Conclusion -- References -- Chapter 12 Voltage-Gated Ion Channels: The Machines Responsible for the Nerve Impulse Benoît Roux and Francisco Bezanilla -- 1. Introduction -- 2. Biological Membranes and Channels -- 3. The Nernst Potential -- 4. Selective Channels and the Action Potential -- 5. Channel Function at the Atomic Level -- 5.1 Fast ion conduction and selectivity -- 5.2 Channel gating and membrane voltage -- 5.3 The functional implications of a focused field -- 6. Future Outlook -- Suggested Additional Reading Materials -- References -- Chapter 13 Voltage-Gated Channels and the Heart Jonathan R. Silva and Yoram Rudy -- 1. Introduction -- 2. Cardiac Electrophysiology Background -- 2.1 Organ level physiology -- 2.2 Cellular level electrophysiology -- 2.2.1 The Hodgkin-Huxley model -- 2.2.2 Modeling the cardiac ventricular action potential -- 2.2.3 Rate dependence -- 2.2.4 β-adrenergic regulation -- 2.2.5 The long QT syndrome -- 3. I as a Molecular Machine -- 3.1 Structure and kinetics -- 3.2 Kinetic modeling of I -- 3.3 Molecular modeling of I -- Conclusion -- Further Reading -- References -- Index. | |
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