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Microneedle-mediated Transdermal and Intradermal Drug Delivery.
One of the latest techniques in drug delivery, microneedles are used for administering a wide range of drug substances used to treat various medical conditions. Thorough background information is included providing a history of the field. Various methods used to produce micorneedles are described as...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken :
John Wiley & Sons,
2012.
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| Edición: | 2nd ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Microneedle-mediated Transdermal and Intradermal Drug Delivery; Contents; Preface; About the Authors; 1 Transdermal Drug Delivery; 1.1 Genesis of transdermal drug delivery; 1.2 Skin anatomy; 1.2.1 The epidermis; 1.2.2 The stratum corneum; 1.2.3 The dermis; 1.2.4 Skin appendages; 1.3 Routes to percutaneous drug absorption; 1.4 Facilitated transdermal drug delivery; 1.4.1 Cryopneumatic and photopneumatic technologies; 1.4.2 Sonophoresis (low-frequency ultrasound); 1.4.3 Iontophoresis; 1.4.4 Electroporation; 1.4.5 Jet injection; 1.4.6 Microneedles; References.
- 2 Microneedles: Design, Microfabrication and Optimization2.1 Introduction; 2.2 Methods of fabricating microneedles; 2.2.1 Microfabrication of silicon microneedles; 2.2.2 Microfabrication of metal and other types of MNs; 2.2.3 Microfabrication of polymeric microneedles; 2.3 Optimization to MN design for transdermal drug delivery; 2.4 Conclusion; References; 3 Microneedle Applicator Designs for Transdermal Drug Delivery Applications; 3.1 Introduction; 3.2 Considerations of microneedle applicators designs; 3.3 Conclusion; References; 4 Transdermal Delivery Applications; 4.1 Introduction.
- 4.2 Transdermal drug delivery4.2.1 Partition co-efficient between 1 and 3; 4.2.2 A relatively low melting point; 4.2.3 A molecular weight less than 500 Da; 4.2.4 Unionized; 4.3 Modulation of transdermal penetration using microneedles; 4.4 Transdermal delivery using solid microneedles; 4.4.1 Transdermal delivery of low molecular weight compounds (RMM <600 Da) in vitro using solid microneedles; 4.4.2 Transdermal delivery of low molecular weight compounds (RMM <600 Da) in vivo using solid microneedles.
- 4.4.3 Transdermal delivery of high molecular weight compounds (RMM> 600 Da) in vitro using solid microneedles4.4.4 Transdermal delivery of high molecular weight compounds (RMM> 600 Da) in vivo using solid microneedles; 4.5 Transdermal delivery using hollow microneedles; 4.5.1 Transdermal delivery of low molecular weight compounds (RMM <600 Da) in vitro using hollow microneedles; 4.5.2 Transdermal delivery of low molecular weight compounds (RMM <600 Da) in vivo using hollow microneedles.
- 4.5.3 Transdermal delivery of high molecular weight compounds (RMM> 600 Da) in vitro using hollow microneedles4.5.4 Transdermal delivery of high molecular weight compounds (RMM> 600 Da) in vivo using hollow microneedles; 4.6 Transdermal delivery using biodegradable microneedles; 4.6.1 Transdermal delivery of low molecular weight compounds in vitro using biodegradable MN; 4.6.2 Transdermal delivery of low molecular weight compounds in vivo using biodegradable MN; 4.6.3 Transdermal delivery of high molecular weight compounds in vitro using biodegradable MN.