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Pharmaceutical process development : current chemical and engineering challenges /
Pharmaceutical process R & D is an exacting, multidisciplinary effort but a somewhat neglected discipline in the chemical curriculum. This book presents an overview of the many facets of process development and how recent advances in synthetic organic chemistry, process technology and chemical e...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge :
Royal Society of Chemistry,
2011.
|
| Colección: | RSC drug discovery series.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 037 | |a T3449 |b Royal Society of Chemistry |n http://www.rsc.org/spr | ||
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| 245 | 0 | 0 | |a Pharmaceutical process development : |b current chemical and engineering challenges / |c editors: John Blacker, Michael T. Williams. |
| 260 | |a Cambridge : |b Royal Society of Chemistry, |c 2011. | ||
| 300 | |a 1 online resource (xx, 354 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a RSC Drug Discovery | |
| 588 | 0 | |a Online resource; title from title screen (viewed on September 19, 2011). | |
| 520 | |a Pharmaceutical process R & D is an exacting, multidisciplinary effort but a somewhat neglected discipline in the chemical curriculum. This book presents an overview of the many facets of process development and how recent advances in synthetic organic chemistry, process technology and chemical engineering have impacted on the manufacture of pharmaceuticals. In 15 concise chapters the book covers such diverse subjects as route selection and economics, the interface with medicinal chemistry, the impact of green chemistry, safety, the crucial role of physical organic measurements in gaining a deeper understanding of chemical behaviour, the role of the analyst, new tools and innovations in reactor design, purification and separation, solid state chemistry and its role in formulation. The book ends with an assessment of future trends and challenges. The book provides a valuable overview of:- Both early and late stage chemical development- How safe and scaleable synthetic routes are designed, selected and developed- The importance of the chemical engineering, analytical & manufacturing interfaces- The key enabling technologies, including catalysis & biocatalysis- The importance of the Green Chemical perspective and solid form issues. The book, written and edited by experts in the field, is a contemporary, holistic treatise, with a logical sequence for process development and mini-case histories within the chapters to bring alive different aspects of the process. It is completely pharmaceutical themed, encompassing all essential aspects, from route and reagent selection to manufacture of the active compound. The book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry. It informs them about the breadth of the work carried out in chemical research and development departments, and gives them a feel for the challenges involved in the job. The book is also of value to academics who often understand the drug discovery arena, but have far less appreciation of the drug development area, and are thus unable to advise their students about the relative merits of careers in chemical development versus discovery. | ||
| 500 | |a Includes index. | ||
| 505 | 0 | |a Foreword; Preface; Introduction; Process Research and Development in the Pharmaceutical Industry: Origins, Evolution and Progress; Active Pharmaceutical Ingredients: Structure and Impact on Synthesis; Rapid Early Development of Potential Drug Candidates; Route Design and Selection The Importance of Green Chemistry in Process Research and Development; Kinetic Approaches for Faster and Efficient Process Development; The Design of Safe Chemical Reactions -- It's No Accident; Physicochemical Data Requirements for the Design of Fine Chemical Processes -- Acquisition and Application; Liquid-Liquid Extraction for Process Development in the Pharmaceutical Industry; Development Enabling Technologies; The Analytical Interface and the Impact on Pharmaceutical Process Development; Materials Science -- Solid Form Design and Crystallisation Process Development; Technology Transfer of API; Future Trends and Challenges. | |
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Drug development. | |
| 650 | 0 | |a Pharmaceutical chemistry. | |
| 650 | 0 | |a Drugs |x Design. | |
| 650 | 2 | |a Drug Design | |
| 650 | 2 | |a Chemistry, Pharmaceutical | |
| 650 | 6 | |a Médicaments |x Développement. | |
| 650 | 6 | |a Chimie pharmaceutique. | |
| 650 | 6 | |a Médicaments |x Conception. | |
| 650 | 7 | |a Industrial applications of scientific research & technological innovation. |2 bicssc | |
| 650 | 7 | |a MEDICAL |x Drug Guides. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Nursing |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Pharmacy. |2 bisacsh | |
| 650 | 7 | |a Drugs |x Design |2 fast | |
| 650 | 7 | |a Drug development |2 fast | |
| 650 | 7 | |a Pharmaceutical chemistry |2 fast | |
| 700 | 1 | |a Blacker, J. G. C. | |
| 700 | 1 | |a Williams, Michael. | |
| 758 | |i has work: |a Pharmaceutical process development (Text) |1 https://id.oclc.org/worldcat/entity/E39PCGbKgBc6mpKYWRrDqKBbHP |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 830 | 0 | |a RSC drug discovery series. | |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=1185963 |z Texto completo |
| 938 | |a Askews and Holts Library Services |b ASKH |n AH30548364 | ||
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| 994 | |a 92 |b IZTAP | ||