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Antiviral drugs : from basic discovery through clinical trials /
This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, N.J. :
Wiley,
©2011.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Frontmatter
- Color Plates
- Human Immunodeficiency Virus. Discovery and Development of Atazanavir / Awny Farajallah, R Todd Bunch, Nicholas A Meanwell
- Discovery and Development of PL-100, A Novel HIV-1 Protease Inhibitor / Jinzi J Wu, Joseph Musto
- Darunavir (Prezista, TMC114): From Bench to Clinic, Improving Treatment Options for HIV-Infected Patients / Marie-Pierre de B̌thune, Vanitha Sekar, Sabrina Spinosa-Guzman, Marc Vanstockem, Sandra De Meyer, Piet Wigerinck, Eric Lefebvre
- Discovery and Development of Tipranavir / Karen R Romines
- TMC278 (Rilpivirine): A Next-Generation NNRTI in Phase III Clinical Development for Treatment-Naive Patients / Jerome Guillemont, Katia Boven, Herta Crauwels, Marie-Pierre de B̌thune
- Etravirine: From TMC125 to Intelence: A Treatment Paradigm Shift for HIV-Infected Patients / Koen Andries, Ann Debunne, Thomas N Kakuda, Michael Kukla, Ruud Leemans, Johan Vingerhoets, Brian Woodfall, Marie-Pierre de B̌thune
- Discovery and Development of Tenofovir Disoproxil Fumarate / Erik De Clercq
- Discovery and Development of Apricitabine / Susan Cox, John Deadman, Justine Southby, Jonathan Coates
- Discovery and Development of Maraviroc and PF-232798: CCR5 Antagonists for the Treatment of HIV-1 Infection / Patrick Dorr, Paul Stupple
- Discovery of the CCR5 Antagonist Vicriviroc (Sch 417690/Sch-D) for the Treatment of HIV-1 Infection / Jayaram R Tagat, Julie M Strizki, Lisa M Dunkle
- Discovery and Development of HIV-1 Entry Inhibitors That Target gp120 / John F Kadow, John Bender, Alicia Regueiro-Ren, Yasutsugu Ueda, Tao Wang, Kap-Sun Yeung, Nicholas A Meanwell
- Discovery of MK-0536: A Potential Second-Generation HIV-1 Integrase Strand Transfer Inhibitor with a High Genetic Barrier to Mutation / Melissa S Egbertson, John S Wai, Mark Cameron, R Scott Hoerrner
- Discovery and Development of HIV Integrase Inhibitor Raltegravir / Vincenzo Summa, Paola Pace
- Elvitegravir: A Novel Monoketo Acid HIV-1 Integrase Strand Transfer Inhibitor / Hisashi Shinkai, Masanori Sato, Yuji Matsuzaki
- Hepatitis C Virus. Discovery and Development of Telaprevir / Anne-Laure Grillot, Luc J Farmer, B Govinda Rao, William P Taylor, Ilan S Weisberg, Ira M Jacobson, Robert B Perni, Ann D Kwong
- Discovery and Development of BILN 2061 and Follow-Up BI 201335 / Montse Llin̉s-Brunet, Peter W White
- Intervention of Hepatitis C Replication through NS3-4A, the Protease Inhibitor Boceprevir / Srikanth Venkatraman, F George Njoroge
- Discovery and Development of the HCV NS3/4A Protease Inhibitor Danoprevir (ITMN-191/RG7227) / Scott D Seiwert, Karl Kossen, Lin Pan, Jyanwei Liu, Brad O Buckman
- Discovery and Development of the HCV Protease Inhibitor TMC435 / Pierre Raboisson, Gregory Fanning, Herman de Kock, Asa Rosenquist, Rene Verloes, Kenneth Simmen
- Discovery and Clinical Evaluation of the Nucleoside Analog Balapiravir (R1626) for the Treatment of HCV Infection / Klaus Klumpp, David B Smith
- Discovery and Development of PSI-6130/RG7128 / Phillip A Furman, Michael J Otto, Michael J Sofia
- Discovery of Cyclophilin Inhibitor NIM811 as a Novel Therapeutic Agent for HCV / Kai Lin
- HCV Viral Entry Inhibitors / Flossie Wong-Staal, Guohong Liu, Jeffrey McKelvy
- Respiratory Syncytial Virus Inhibitors. Discovery of the RSV Inhibitor TMC353121 / Jean-Fraṅois Bonfanti, Gabriela Ispas, Frans Van Velsen, Wieslawa Olszewska, Tom Gevers, Dirk Roymans
- Discovery and Development of Orally Active RSV Fusion Inhibitors / Nicholas A Meanwell, Christopher W Cianci, Mark R Krystal
- Discovery and Development of RSV604 / Joanna Chapman, Stuart Cockerill
- Influenza, Hepatitis B, and Cytomegalovirus Inhibitors. Discovery and Development of Influenza Virus Sialidase Inhibitor Relenza / Robin Thomson, Mark von Itzstein
- Discovery and Development of Entecavir / Richard Wilber, Bruce Kreter, Marc Bifano, Stephanie Danetz, Lois Lehman-McKeeman, Daniel J Tenney, Nicholas Meanwell, Robert Zahler, Helena Brett-Smith
- Benzimidazole Ribonucleosides: Novel Drug Candidates for the Prevention and Treatment of Cytomegalovirus Diseases / Karen K Biron, Kristjan S Gudmundsson, John C Drach
- Index.