Kinetics of Enzyme Action : Essential Principles for Drug Hunters /

"Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions a...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Stein, Ross L.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, N.J. : Wiley, ©2011.
Temas:
Enzymes > Pharmacokinetics.
Enzyme inhibitors > Pharmacokinetics.
Enzyme activation.
Enzymes > pharmacokinetics
Drug Discovery
Enzyme Activation
Enzyme Inhibitors > pharmacokinetics
Enzymes > Pharmacocinétique.
Antienzymes > Pharmacocinétique.
Enzymes > Activation.
SCIENCE > Life Sciences > Biochemistry.
Enzyme activation
Electronic resource.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Frontmatter
  • Introduction
  • Kinetics of Single-Substrate Enzymatic Reactions
  • Kinetics of Single-Substrate Enzymatic Reactions: Special Topics
  • Enzyme Inhibition: The Phenomenon and Mechanism-Independent Analysis
  • Kinetic Mechanism of Inhibition of One-Substrate Enzymatic Reactions
  • Tight-Binding, Slow-Binding, and Irreversible Inhibition
  • Kinetics of Two-Substrate Enzymatic Reactions
  • Kinetic Mechanism of Inhibition of Two-Substrate Enzymatic Reactions
  • Allosteric Modulation of Enzyme Activity
  • Kinetics-Based Probes of Mechanism
  • Appendix A: Basic Principles of Chemical Kinetics
  • Appendix B: Transition State Theory and Enzymology: Enzyme Catalytic Power and Inhibitor Design
  • Appendix C: Selecting Substrate Concentrations for High-Throughput Screens
  • Index.
  • Kinetics of single-substrate enzymatic reactions
  • Kinetics of single-substrate enzymatic reactions : special topics
  • Enzyme inhibition : the phenomenon and mechanistic analysis
  • Kinetic mechanism of inhibition of one-substrate enzymatic reactions
  • Tight-binding, slow-binding, and irreversible inhibitors
  • Kinetics of two-substrate enzymatic reactions
  • Kinetic mechanism of inhibition of two-substrate enzymatic reactions
  • Allosteric modulation of enzyme-catalyzed reactions
  • Kinetics-based probes of enzyme mechanisms.

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