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Human Oncogenic Viruses.
Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and the cancers th...
| Clasificación: | Libro Electrónico |
|---|---|
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
World Scientific
2009.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover13;
- Contents
- Foreword
- Preface
- Chapter 1 Oncogenic Viruses, Cellular Transformation and Human Cancers Yanyan Zheng and Jing-hsiung James Ou
- 1. Introduction and Historical Aspects
- 2. Human Oncogenic Viruses
- 2.1. Hepatitis B Virus (HBV)
- 2.2. Hepatitis C Virus (HCV)
- 2.3. Human Papilloma Virus (HPV)
- 2.4. Epstein-Barr Virus (EBV)
- 2.5. Kaposis Sarcoma-associated Herpesvirus (KSHV)
- 2.6. Human T-cell Leukemia Virus-1 (HTLV-1)
- 3. Mechanisms of Virus-induced Cellular Transformation
- 3.1. Perturbation of Signaling Pathways
- 3.2. Deregulation of the Cell Cycle
- 3.3. Escape of Apoptosis
- 3.4. Immortalization of Cells
- 3.5. Induction of Genetic Instability
- 3.6. Insertional Mutagenesis
- 3.7. Induction of Chronic Inflammation
- 4. Concluding Remarks
- Bibliography
- Chapter 2 Hepatitis B Virus and Hepatocellular Carcinogenesis T.S. Benedict Yen
- 1. Hepatitis B Virus and Hepatocellular Carcinoma
- 2. Biology and Epidemiology of HBV
- 3. HBV Virology
- 4. Prevention and Treatment of HBV
- 5. Mechanisms of HBV Carcinogenesis
- 5.1. Overview
- 5.2. HBV-specific Factors
- 5.3. Role of Liver Injury and Inflammation
- 5.4. Dietary Carcinogens
- 5.5. Other Aspects of HBV Oncogenesis
- 6. Summary
- Note
- References
- Chapter 3 Molecular Mechanism of Hepatitis C Virus Carcinogenesis Keigo Machida, Jing-hsiung James Ou and Michael M.C. Lai
- 1. Introduction
- 2. Molecular Carcinogenesis of HCV
- 2.1. Induction of Mutator Phenotype
- 2.2. Chromosome Translocation
- 2.3. Reactive Oxygen Species (ROS)
- 2.4. Nitric Oxide
- 2.5. Inhibition of DNA Damage Repair
- 2.6. Oncogenic Activities of the HCV Core Protein
- 2.7. Oncogenic Activities of the HCV NS5A Protein
- 3. Other Causative Factors in HCV-associated HCC
- 3.1. Chronic Liver Inflammation
- 3.2. Alcohol
- 4. Endoplasmic Reticulum Stress and HCV Pathogenesis
- 5. Gene Expression Profile of HCC
- 6. HCV and Lymphomagenesis
- 6.1. Induction of IgHypermutation by HCV
- 6.2. Induction of DNA Translocation between IgGenes and Proto-Oncogenes by HCV
- 6.3. Dual Signaling Model for HCV-induced Mutagenesis in B Cells
- 6.4. HCV and Non-Hodgkins B-cell Lymphomas
- 7. Conclusions
- References
- Chapter 4 Human Papillomaviruses and Associated Malignancies Christine L. Nguyen, Margaret E. McLaughlin-Drubin and Karl M252;nger
- 1. Introduction
- 2. Viral Life Cycle
- 2.1. Viral Genome
- 2.2. Infection
- 2.3. Productive Viral Infection
- 3. Clinical Disease
- 3.1. Prevalence
- 3.2. Pathology
- 4. Detection, Treatment, and Prevention
- 4.1. Screening and Detection
- 4.2. Diagnosis and Treatment
- 4.3. Prevention and Vaccines
- 5. Carcinogenic Progression and Viral Oncoproteins
- 5.1. Carcinogenic Progression
- 5.2. Viral Oncoproteins
- 6. Genomic Instability in HPV-Associated Cancers
- 6.1. Deregulation of the Cell Cycle in HPV-Associated Cancers
- 6.2. Centrosomal Defects in HPV-Associated Cancers
- 6.3. Mitotic Errors in HPV-Associated Cancers
- 7. Concluding Remarks
- References
- Chapter 5 Epstein-Barr Virus and Its Oncogenesis Hsin-Pai Li, Mei Chao, Shu-Jen Chen and Yu-Sun Chang
- 1. Introduction
- 2. EBNA1
- 2.1. Differential Promoter Selection of EBNA1 Transcripts
- 2.2. EBNA1 Protein Dom.