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Human Oncogenic Viruses.

Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and the cancers th...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Formato: Electrónico eBook
Idioma:Inglés
Publicado: World Scientific 2009.
Temas:
Acceso en línea:Texto completo

MARC

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505 0 |a Cover13; -- Contents -- Foreword -- Preface -- Chapter 1 Oncogenic Viruses, Cellular Transformation and Human Cancers Yanyan Zheng and Jing-hsiung James Ou -- 1. Introduction and Historical Aspects -- 2. Human Oncogenic Viruses -- 2.1. Hepatitis B Virus (HBV) -- 2.2. Hepatitis C Virus (HCV) -- 2.3. Human Papilloma Virus (HPV) -- 2.4. Epstein-Barr Virus (EBV) -- 2.5. Kaposis Sarcoma-associated Herpesvirus (KSHV) -- 2.6. Human T-cell Leukemia Virus-1 (HTLV-1) -- 3. Mechanisms of Virus-induced Cellular Transformation -- 3.1. Perturbation of Signaling Pathways -- 3.2. Deregulation of the Cell Cycle -- 3.3. Escape of Apoptosis -- 3.4. Immortalization of Cells -- 3.5. Induction of Genetic Instability -- 3.6. Insertional Mutagenesis -- 3.7. Induction of Chronic Inflammation -- 4. Concluding Remarks -- Bibliography -- Chapter 2 Hepatitis B Virus and Hepatocellular Carcinogenesis T.S. Benedict Yen -- 1. Hepatitis B Virus and Hepatocellular Carcinoma -- 2. Biology and Epidemiology of HBV -- 3. HBV Virology -- 4. Prevention and Treatment of HBV -- 5. Mechanisms of HBV Carcinogenesis -- 5.1. Overview -- 5.2. HBV-specific Factors -- 5.3. Role of Liver Injury and Inflammation -- 5.4. Dietary Carcinogens -- 5.5. Other Aspects of HBV Oncogenesis -- 6. Summary -- Note -- References -- Chapter 3 Molecular Mechanism of Hepatitis C Virus Carcinogenesis Keigo Machida, Jing-hsiung James Ou and Michael M.C. Lai -- 1. Introduction -- 2. Molecular Carcinogenesis of HCV -- 2.1. Induction of Mutator Phenotype -- 2.2. Chromosome Translocation -- 2.3. Reactive Oxygen Species (ROS) -- 2.4. Nitric Oxide -- 2.5. Inhibition of DNA Damage Repair -- 2.6. Oncogenic Activities of the HCV Core Protein -- 2.7. Oncogenic Activities of the HCV NS5A Protein -- 3. Other Causative Factors in HCV-associated HCC -- 3.1. Chronic Liver Inflammation -- 3.2. Alcohol -- 4. Endoplasmic Reticulum Stress and HCV Pathogenesis -- 5. Gene Expression Profile of HCC -- 6. HCV and Lymphomagenesis -- 6.1. Induction of IgHypermutation by HCV -- 6.2. Induction of DNA Translocation between IgGenes and Proto-Oncogenes by HCV -- 6.3. Dual Signaling Model for HCV-induced Mutagenesis in B Cells -- 6.4. HCV and Non-Hodgkins B-cell Lymphomas -- 7. Conclusions -- References -- Chapter 4 Human Papillomaviruses and Associated Malignancies Christine L. Nguyen, Margaret E. McLaughlin-Drubin and Karl M252;nger -- 1. Introduction -- 2. Viral Life Cycle -- 2.1. Viral Genome -- 2.2. Infection -- 2.3. Productive Viral Infection -- 3. Clinical Disease -- 3.1. Prevalence -- 3.2. Pathology -- 4. Detection, Treatment, and Prevention -- 4.1. Screening and Detection -- 4.2. Diagnosis and Treatment -- 4.3. Prevention and Vaccines -- 5. Carcinogenic Progression and Viral Oncoproteins -- 5.1. Carcinogenic Progression -- 5.2. Viral Oncoproteins -- 6. Genomic Instability in HPV-Associated Cancers -- 6.1. Deregulation of the Cell Cycle in HPV-Associated Cancers -- 6.2. Centrosomal Defects in HPV-Associated Cancers -- 6.3. Mitotic Errors in HPV-Associated Cancers -- 7. Concluding Remarks -- References -- Chapter 5 Epstein-Barr Virus and Its Oncogenesis Hsin-Pai Li, Mei Chao, Shu-Jen Chen and Yu-Sun Chang -- 1. Introduction -- 2. EBNA1 -- 2.1. Differential Promoter Selection of EBNA1 Transcripts -- 2.2. EBNA1 Protein Dom. 
520 |a Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and the cancers they cause. Viruses that are discussed in the individual chapters include hepatitis B virus, hepatitis C virus, human papilloma viruses, Epstein-Barr virus, Kaposi's sarcoma virus and human T-cell leukemia virus type 1. This book provides up-to-date information for graduate students, postdoctoral fell. 
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650 0 |a Oncogenic viruses. 
650 0 |a Hepatitis viruses. 
650 0 |a Herpesviruses. 
650 0 |a Life sciences. 
650 0 |a Physiology. 
650 0 |a Physical sciences. 
650 0 |a Viruses. 
650 2 |a Biological Science Disciplines 
650 2 |a Vertebrate Viruses 
650 2 |a Physiology 
650 2 |a Oncogenic Viruses 
650 2 |a Natural Science Disciplines 
650 2 |a Viruses 
650 2 |a Organisms 
650 2 |a Disciplines and Occupations 
650 2 |a Hepatitis Viruses 
650 6 |a Virus oncogènes. 
650 6 |a Virus de l'hépatite. 
650 6 |a Herpèsvirus. 
650 6 |a Sciences de la vie. 
650 6 |a Physiologie. 
650 6 |a Sciences physiques. 
650 6 |a Virus. 
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650 7 |a physiology.  |2 aat 
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650 7 |a Viruses  |2 fast 
650 7 |a Physiology  |2 fast 
650 7 |a Physical sciences  |2 fast 
650 7 |a Life sciences  |2 fast 
650 7 |a Hepatitis viruses  |2 fast 
650 7 |a Herpesviruses  |2 fast 
650 7 |a Oncogenic viruses  |2 fast 
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720 |a Ou Jing-Hsiung James Et Al. 
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