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Perspectives On Vasopressin.
Vasopressin is a hormone which has an increasingly important profile. Not only does it play a physiologically significant role in renal water regulation but it also has other renal actions and plays a role in overall cardiovascular control. Even more interesting is the recent growing interest in its...
| Clasificación: | Libro Electrónico |
|---|---|
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
World Scientific
2009.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover13;
- Contents
- Preface
- Chapter 1. Introduction to Vasopressin (John Laycock)
- 1. Brief Historical Perspective
- 2. General Development, Anatomy and Structure of the Neurohypophysial System
- 3. Synthesis, Storage and Release of Neurohypophysial Hormones
- 4. Vasopressin Assays
- 5. Physiological Actions
- 6. Receptors and Mechanisms of Action
- 7. Circulation and Metabolism
- 8. Control of Release of Vasopressin
- 9. Clinical Aspects of Vasopressin
- 10. Conclusion
- Bibliography
- Chapter 2. Comparative and Evolutionary Aspects of Vasopressin (Jacques Hanoune)
- 1. Introduction
- 2. Evolutionary Aspects of the Vasopressin Family
- 3. Evolutionary Aspects of the Vasopressin Receptor Family
- 4. Evolutionary Aspects of the Aquaporin Family
- 5. Conclusion
- Bibliography
- Chapter 3. The Neurohypophysial System: Synthesis and Metabolism of Vasopressin (Jacques Hanoune)
- 1. Developmental Aspects of the Endocrine Hypothalamus
- 2. Biosynthesis
- a) Gene structure
- b) Processing of the mature peptide
- 3. Control of Vasopressin Secretion
- a) Control by extracellular osmolality and volaemia
- b) Additional factors
- 4. Extra-hypothalamic Expression of Vasopressin
- a) Adrenal medulla
- b) Testis
- c) Blood vessels and heart
- d) Other organs
- 5. Peripheral Degradation and Metabolic Clearance
- Bibliography
- Chapter 4. Vasopressin Receptors, the Signalling Cascade and Mechanisms of Action (Jacques Hanoune)
- 1. Introduction: A Short Historical Survey of Vasopressin Receptors
- 2. Pharmacological Characterization of the Vasopressin Receptors
- 3. Biochemical Characterization of the Vasopressin Receptors
- 4. Tissue Expression
- a) V1a receptor
- b) V1b (V3) receptor
- c) V2 receptor
- 5. Vasopressin Receptors and G Proteins: An Overview
- 6. Structure of the Vasopressin Receptors
- a) General features
- b) Modelling of vasopressin receptors
- 7. Structural Basis of the Receptor-Ligand Interaction
- a) Binding of agonists
- b) Binding of antagonists
- 8. Domains Responsible for G Protein-Coupling Selectivity
- 9. Dimerization of Receptors
- 10. Signalling Pathways
- a) The heterotrimeric G protein
- b) The cyclic AMP pathway
- c) The calcium/phosphatidyl inositol pathway
- d) The V2 receptor pathway
- e) The V1a receptor pathway
- f) The V1b receptor pathway
- g) The proteomic approach
- 11. Pre- and Post-transcriptional Regulation of Vasopressin Receptor Expression
- 12. Downregulation of Vasopressin Receptors: Desensitization and Internalization
- 13. Are There Other Vasopressin Receptors?
- Bibliography
- Chapter 5. Pharmacology of the Vasopressin Receptors (Jacques Hanoune)
- 1. Introduction
- 2. Radio-labelled Ligands
- 3. Pharmacology of the Vasopressin V1a Receptor
- 4. Pharmacology of the Vasopressin V1b Receptor
- 5. Pharmacology of the Vasopressin V2 Receptor
- 6. Mixed Vasopressin V1a/V2 Receptor Antagonists
- 7. Inter-species and Inter-organ Variability
- 8. Conclusion
- Bibliography
- Chapter 6. Vasopressin and Its Renal Effects (John Laycock)
- 1. Introduction
- 2. The Kidneys
- 3. The Renal Actions of Vasopressin
- a) Glomerular filtration and renal blood flow
- b) Vasopressin and the proximal tubule
- c) Vasopressin and the loop of Henle
- d) Vasopressin an.