Cellular senescence : implications for cancer therapy /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Mirzayans, Razmik
Otros Autores: Murray, David, Ph. D.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Nova Science Publications, Inc, ©2009.
Temas:
Cells > Aging.
Cancer > Treatment.
Cellular Senescence > physiology
Neoplasms > therapy
Cellular Senescence.
Cellules > Vieillissement.
Cancer > Traitement.
MEDICAL > Oncology.
HEALTH & FITNESS > Diseases > Cancer.
Cancer > Treatment
Cells > Aging
Acceso en línea:Texto completo
Tabla de Contenidos:
  • CELLULAR SENESCENCE:IMPLICATIONS FORCANCER THERAPY; CONTENTS; PREFACE; INTRODUCTION; TELOMERASE-BASED SENESCENCE; STRESS-TRIGGERED PREMATURESENESCENCE; FEATURES OF PREMATURE SENESCENCE; CELL MORPHOLOGY; SENESCENCE-ASSOCIATED Ý-GALACTOSIDASEEXPRESSION; SUSTAINED P21 UP-REGULATION; INHIBITION OF CELL GROWTH; NUCLEAR ACCUMULATION OF ACTIN; STRESS-ASSOCIATED NUCLEAR FOCI; NUCLEAR ACCUMULATION OF ACTIN; STRESS-ASSOCIATED NUCLEAR FOCI; DIFFERENT MODES OF GROWTHARREST ARE TRIGGERED BYGENOTOXIC STRESS; CLASSIFICATION OF CDK INHIBITORS; ROLES OF P21, P53 AND P16IN SENESCENCE.
  • REGULATION OF P21WAF1 TRANSCRIPTAND P21 PROTEIN LEVELSMODE OF ACTION OF P21; P53 SIGNALING AND CELLULARRESPONSE TO DNA-DAMAGING AGENTS; IONIZING RADIATION-TRIGGERED RESPONSES; UV-TRIGGERED RESPONSES; APOPTOTIC THRESHOLD IN CANCER CELLS EXPOSEDTO DNA-DAMAGING AGENTS; WHAT FACTORS MIGHT CONTRIBUTE TO THEAPOPTOTIC THRESHOLD?; CELL-TO-CELL COMMUNICATIONTRIGGERED BY DNA-DAMAGING AGENTS; ROS-ASSOCIATED BYSTANDER EFFECT OFRADIATION; P53-MEDIATED BYSTANDER EFFECT OF RADIATION; DIFFUSIBLE "AT-CORRECTING" FACTORS; MODULATING SENESCENCE IN THECONTEXT OF CANCER THERAPY.
  • PROS AND CONS OF ACTIVATING SENESCENCE INCANCER CELLSASSAYS FOR PRECLINICAL TESTING OF ANTICANCERAGENTS; AGING, SENESCENCE, AND "HORMESIS"; HUMAN GENETIC DISORDERSASSOCIATED WITH GENOMICINSTABILITY AND CANCERPREDISPOSITION; WERNER SYNDROME; HUTCHINSON-GILFORD'S PROGERIA SYNDROME; BLOOM SYNDROME; ROTHMUND-THOMPSON SYNDROME; COCKAYNE SYNDROME; XERODERMA PIGMENTOSUM; FANCONI ANEMIA; ATAXIA TELANGIECTASIA; LI-FRAUMENI SYNDROME.
  • BIOLOGICAL CONSEQUENCES OF THE FAILURE OF CELLS TO UNDERGO SENESCENCE/APOPTOSIS FOLLOWING GENOTOXIC STRESS: BASIS FOR THE EMERGENCE OF HIGHLY METASTATIC AND THERAPY-RESISTANT DISEASE?CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; INDEX.

Ejemplares similares