GPCR molecular pharmacology and drug targeting : shifting paradigms and new directions /

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G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look a...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Gilchrist, Annette
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, N.J. : Wiley, ©2010.
Temas:
G proteins.
Drug targeting.
Molecular structure.
Receptors, G-Protein-Coupled > physiology
Drug Delivery Systems
Molecular Structure
GTP-Binding Proteins
Protéines G.
Médicaments > Ciblage.
Structure moléculaire.
molecular structure.
MEDICAL > Biochemistry.
Molecular structure
Drug targeting
G proteins
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Frontmatter
  • The Evolution of Receptors: From On-Off Switches to Microprocessors / Terry Kenakin
  • The Evolving Pharmacology of GPCRs / Lauren T May, Nicholas D Holliday, Stephen J Hill
  • The Emergence of Allosteric Modulators for G Protein-Coupled Receptors / Karen J Gregory, Celine Valant, John Simms, Patrick M Sexton, Arthur Christopoulos
  • Receptor-Mediated G Protein Activation: How, How Many, and Where? / Ingrid Gsandtner, Christian W Gruber, Michael Freissmuth
  • Molecular Pharmacology of Frizzleds with Implications for Possible Therapy / Gunnar Schulte
  • Secretin Receptor Dimerization: A Possible Functionally Important Paradigm for Family B G Protein-Coupled Receptors / Kaleeckal G Harikumar, Maoqing Dong, Laurence J Miller
  • Past and Future Strategies for GPCR Deorphanization / Anǧlique Levoye, Nathalie Clement, Elodie Tenconi, Ralf Jockers
  • High-Throughput GPCR Screening Technologies and the Emerging Importance of the Cell Phenotype / Terry Reisine, Richard M Eglen
  • Are ₃Traditional₄ Biochemical Techniques Out of Fashion in the New Era of GPCR Pharmacology? / Maria Teresa Dell'Anno, Maria Rosa Mazzoni
  • Fluorescence and Resonance Energy Transfer Shine New Light on GPCR Function / Carsten Hoffmann, Moritz Bünemann
  • Integration of Label-Free Detection Methods in GPCR Drug Discovery / Oliver Nayler, Magdalena Birker-Robaczewska, John Gatfield
  • Screening for Allosteric Modulators of G Protein-Coupled Receptors / Christopher Langmead
  • Ultra-High-Throughput Screening Assays for GPCRs / Priya Kunapuli
  • New Techniques to Express and Crystallize G Protein-Coupled Receptors / James C Errey, Fiona H Marshall
  • Structure and Modeling of GPCRs: Implications for Drug Discovery / Kimberly A Reynolds, Vsevolod Katritch, Ruben Abagyan
  • X-Ray Structure Developments for GPCR Drug Targets / Michael Sabio, Sidney W Topiol
  • Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled Receptors / Kenneth J Valenzano, Elfrida R Benjamin, Patricia René, Michel Bouvier
  • Index.

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