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GPCR molecular pharmacology and drug targeting : shifting paradigms and new directions /
G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look a...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, N.J. :
Wiley,
©2010.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a GPCR molecular pharmacology and drug targeting : |b shifting paradigms and new directions / |c edited by Annette Gilchrist. |
| 260 | |a Hoboken, N.J. : |b Wiley, |c ©2010. | ||
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 505 | 0 | |a Frontmatter -- The Evolution of Receptors: From On-Off Switches to Microprocessors / Terry Kenakin -- The Evolving Pharmacology of GPCRs / Lauren T May, Nicholas D Holliday, Stephen J Hill -- The Emergence of Allosteric Modulators for G Protein-Coupled Receptors / Karen J Gregory, Celine Valant, John Simms, Patrick M Sexton, Arthur Christopoulos -- Receptor-Mediated G Protein Activation: How, How Many, and Where? / Ingrid Gsandtner, Christian W Gruber, Michael Freissmuth -- Molecular Pharmacology of Frizzleds with Implications for Possible Therapy / Gunnar Schulte -- Secretin Receptor Dimerization: A Possible Functionally Important Paradigm for Family B G Protein-Coupled Receptors / Kaleeckal G Harikumar, Maoqing Dong, Laurence J Miller -- Past and Future Strategies for GPCR Deorphanization / Anǧlique Levoye, Nathalie Clement, Elodie Tenconi, Ralf Jockers -- High-Throughput GPCR Screening Technologies and the Emerging Importance of the Cell Phenotype / Terry Reisine, Richard M Eglen -- Are ₃Traditional₄ Biochemical Techniques Out of Fashion in the New Era of GPCR Pharmacology? / Maria Teresa Dell'Anno, Maria Rosa Mazzoni -- Fluorescence and Resonance Energy Transfer Shine New Light on GPCR Function / Carsten Hoffmann, Moritz Bünemann -- Integration of Label-Free Detection Methods in GPCR Drug Discovery / Oliver Nayler, Magdalena Birker-Robaczewska, John Gatfield -- Screening for Allosteric Modulators of G Protein-Coupled Receptors / Christopher Langmead -- Ultra-High-Throughput Screening Assays for GPCRs / Priya Kunapuli -- New Techniques to Express and Crystallize G Protein-Coupled Receptors / James C Errey, Fiona H Marshall -- Structure and Modeling of GPCRs: Implications for Drug Discovery / Kimberly A Reynolds, Vsevolod Katritch, Ruben Abagyan -- X-Ray Structure Developments for GPCR Drug Targets / Michael Sabio, Sidney W Topiol -- Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled Receptors / Kenneth J Valenzano, Elfrida R Benjamin, Patricia René, Michel Bouvier -- Index. | |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference. | ||
| 588 | 0 | |a Print version record. | |
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a G proteins. | |
| 650 | 0 | |a Drug targeting. | |
| 650 | 0 | |a Molecular structure. | |
| 650 | 2 | |a Receptors, G-Protein-Coupled |x physiology | |
| 650 | 2 | |a Drug Delivery Systems | |
| 650 | 2 | |a Molecular Structure | |
| 650 | 2 | |a GTP-Binding Proteins | |
| 650 | 6 | |a Protéines G. | |
| 650 | 6 | |a Médicaments |x Ciblage. | |
| 650 | 6 | |a Structure moléculaire. | |
| 650 | 7 | |a molecular structure. |2 aat | |
| 650 | 7 | |a MEDICAL |x Biochemistry. |2 bisacsh | |
| 650 | 7 | |a Molecular structure |2 fast | |
| 650 | 7 | |a Drug targeting |2 fast | |
| 650 | 7 | |a G proteins |2 fast | |
| 700 | 1 | |a Gilchrist, Annette. | |
| 758 | |i has work: |a GPCR molecular pharmacology and drug targeting (Text) |1 https://id.oclc.org/worldcat/entity/E39PCH4xBPY9c9hRMYJRTvJJjC |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
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| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=540093 |z Texto completo |
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