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DNA microarray technology and data analysis in cancer research /

DNA microarray technology has become a useful technique in gene expression analysis for the development of new diagnostic tools and for the identification of disease genes and therapeutic targets for human cancers. Appropriate control for DNA microarray experiment and reliable analysis of the array...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Li, Shaoguang
Otros Autores: Li, Dongguang
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Singapore ; Hackensack, NJ : World Scientific, ©2008.
Temas:
Acceso en línea:Texto completo

MARC

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049 |a UAMI 
100 1 |a Li, Shaoguang. 
245 1 0 |a DNA microarray technology and data analysis in cancer research /  |c Shaoguang Li, Dongguang Li. 
260 |a Singapore ;  |a Hackensack, NJ :  |b World Scientific,  |c ©2008. 
300 |a 1 online resource (xi, 118 pages) :  |b illustrations (some color) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a data file  |2 rda 
504 |a Includes bibliographical references (pages 105-115) and index. 
505 0 |a ch. 1. DNA microarray technology. 1.1. Experimental procedure. 1.2. Experimental design. 1.3. Quality control. 1.4. Interpretation of DNA microarray data. 1.5. Advantages and disadvantages -- ch. 2. Applications of DNA microarray technology in cancer research. 2.1. Solid tumors. 2.2. Blood cancers. 2.3. Our DNA microarray study using mouse -- ch. 3. Current analytical methods of DNA microarray data. 3.1. Experimental design. 3.2. Method. 3.3. Quality control diagnostics. 3.4. Statistical analysis. 3.5. Coefficient of variation analysis -- ch. 4. A novel method for DNA microarray data analysis : SDL global optimization method. 4.1. Research subjects. 4.2. Experimental design. 4.3. Fold change analysis -- 4.4. More information on SDL global optimization -- ch. 5. Applications of the SDL global optimization method in DNA microarray data analysis. 5.1. Leukemia cell line study. 5.2. Analyses of publicly available human microarray data. 5.3. Overall methodology. 5.4. Experimental results. 5.5. Discussion. 5.6. Conclusion -- ch. 6. General discussion and future directions. 
520 |a DNA microarray technology has become a useful technique in gene expression analysis for the development of new diagnostic tools and for the identification of disease genes and therapeutic targets for human cancers. Appropriate control for DNA microarray experiment and reliable analysis of the array data are key to performing the assay and utilizing the data correctly. The most difficult challenge has been the lack of a powerful method to analyze the data for all genes (more than 30,000 genes) simultaneously and to use the microarray data in a decision-making process. In this book, the authors describe DNA microarray technology and data analysis by pointing out current advantages and disadvantages of the technique and available analytical methods. Crucially, new ideas and analytical methods based on the authors' own experience in DNA microarray study and analysis are introduced. It is believed that this new way of interpreting and analyzing microarray data will bring us closer to success in decision-making using the information obtained through the DNA microarray technology. 
588 0 |a Print version record. 
546 |a English. 
590 |a eBooks on EBSCOhost  |b EBSCO eBook Subscription Academic Collection - Worldwide 
590 |a ProQuest Ebook Central  |b Ebook Central Academic Complete 
650 0 |a Cancer cells  |x Growth  |x Regulation. 
650 0 |a DNA microarrays. 
650 0 |a Diseases. 
650 0 |a Methodology. 
650 0 |a Research. 
650 0 |a Gene expression. 
650 0 |a Science. 
650 0 |a Nucleic acid hybridization. 
650 0 |a Decision making  |x Mathematical models. 
650 0 |a Genetics  |x Technique. 
650 0 |a Physical sciences. 
650 2 |a Genetic Phenomena 
650 2 |a Disease 
650 2 |a Methods 
650 2 |a Sequence Analysis 
650 2 |a Oligonucleotide Array Sequence Analysis  |x methods 
650 2 |a Oligonucleotide Array Sequence Analysis 
650 2 |a Neoplasms 
650 2 |a Data Interpretation, Statistical 
650 2 |a Research 
650 2 |a Gene Expression 
650 2 |a Science 
650 2 |a Investigative Techniques 
650 2 |a Molecular Probe Techniques 
650 2 |a Microarray Analysis 
650 2 |a Nucleic Acid Hybridization 
650 2 |a Decision Support Techniques 
650 2 |a Analytical, Diagnostic and Therapeutic Techniques and Equipment 
650 2 |a Genetic Techniques 
650 2 |a Microchip Analytical Procedures 
650 2 |a Natural Science Disciplines 
650 2 |a Chemistry Techniques, Analytical 
650 2 |a Phenomena and Processes 
650 2 |a Disciplines and Occupations 
650 6 |a Cellules cancéreuses  |x Croissance  |x Régulation. 
650 6 |a Puces à ADN. 
650 6 |a Maladies. 
650 6 |a Méthodologie. 
650 6 |a Recherche. 
650 6 |a Expression génique. 
650 6 |a Sciences. 
650 6 |a Acides nucléiques  |x Hybridation. 
650 6 |a Prise de décision  |x Modèles mathématiques. 
650 6 |a Génétique  |x Technique. 
650 6 |a Sciences physiques. 
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650 7 |a methodology.  |2 aat 
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650 7 |a sciences (philosophy)  |2 aat 
650 7 |a physical sciences.  |2 aat 
650 7 |a science (modern discipline)  |2 aat 
650 7 |a MEDICAL  |x Oncology.  |2 bisacsh 
650 7 |a HEALTH & FITNESS  |x Diseases  |x Cancer.  |2 bisacsh 
650 7 |a Science  |2 fast 
650 7 |a Research  |2 fast 
650 7 |a Physical sciences  |2 fast 
650 7 |a Nucleic acid hybridization  |2 fast 
650 7 |a Methodology  |2 fast 
650 7 |a Genetics  |x Technique  |2 fast 
650 7 |a Gene expression  |2 fast 
650 7 |a Diseases  |2 fast 
650 7 |a Decision making  |x Mathematical models  |2 fast 
650 7 |a Cancer cells  |x Growth  |x Regulation  |2 fast 
650 7 |a DNA microarrays  |2 fast 
700 1 |a Li, Dongguang. 
758 |i has work:  |a DNA microarray technology and data analysis in cancer research (Text)  |1 https://id.oclc.org/worldcat/entity/E39PCGvR3mwHhRxHvMwC8Gm9Kq  |4 https://id.oclc.org/worldcat/ontology/hasWork 
776 0 8 |i Print version:  |a Li, Shaoguang.  |t DNA microarray technology and data analysis in cancer research.  |d Singapore ; Hackensack, NJ : World Scientific, ©2008  |w (DLC) 2009277979 
856 4 0 |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=477188  |z Texto completo 
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