Lead generation approaches in drug discovery /

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An integrated overview of modern approaches to lead discovery. Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to im...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Rankovic, Zoran, Morphy, Richard
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, N.J. : John Wiley, ©2010.
Temas:
Drug development.
Drugs > Design.
High throughput screening (Drug development)
Lead.
Drug Discovery > methods
Lead
Drug Design
Médicaments > Développement.
Médicaments > Conception.
Criblage à haut débit (Développement des médicaments)
Plomb.
MEDICAL > Drug Guides.
MEDICAL > Pharmacology.
MEDICAL > Pharmacy.
MEDICAL > Nursing > Pharmacology.
Drug development
Drugs > Design
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Lead discovery : the process / William F. Michne
  • High throughput screening approach to lead discovery / Zoran Rankovic, Craig Jamieson, and Richard Morphy
  • In silico screening / Dagmar Stumpfe, Hanna Geppert, and Jürgen Bajorath
  • Fragment-based lead discovery / Jeffrey S. Albert
  • Design of multitarget ligands / Richard Morphy and Zoran Rankovic
  • De novo drug design / Gisbert Schneider, Markus Hartenfeller, Ewgenij Proschak
  • Role of natural products in drug discovery / Hugo Lachance, Stefan Wetzel, and Herbert Waldmann
  • Early screening for ADMET properties / Dennis A. Smith
  • Role of chemistry in lead discovery / Roland E. Dolle and Karin Worm.

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