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New frontiers in chemical biology : enabling drug discovery /
Annotation
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge :
Royal Society of Chemistry,
©2010.
|
| Colección: | RSC drug discovery series ;
5. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 037 | |a T3317 |b Royal Society of Chemistry |n http://www.rsc.org/spr | ||
| 050 | 4 | |a RS420 |b .N49 2010 | |
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| 049 | |a UAMI | ||
| 245 | 0 | 0 | |a New frontiers in chemical biology : |b enabling drug discovery / |c [edited by] Mark Bunnage, David Thurston, David Fox. |
| 260 | |a Cambridge : |b Royal Society of Chemistry, |c ©2010. | ||
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a RSC drug discovery ; |v 5 | |
| 520 | 8 | |a Annotation |b Despite ever-increasing investment in biomedical research, there has been a significant decline in the number of new drug approvals in recent years. In an effort to improve productivity, the drug discovery community has increasingly looked to biotherapeutics such as antibodies, vaccines, nucleic acids, and peptides. Chemical biology is an emerging field at the interface between chemistry and biology. It utilises the tools and techniques of chemical synthesis to study and influence biological systems. Recent developments in this area have great potential in addressing the productivity challenges expressed above. For example, chemical biology studies have already led to the identification of novel targets with exciting therapeutic potential and it is clear that the field will prove a key enabler of target discovery in the future. Moreover, the precise synthetic manipulation of biological molecules involved in many chemical biology approaches is now fuelling a new wave of chemically-modified biologics, 'chemologics', with unique properties. In these, and many other ways, chemical biology is a key discipline within 21st century drug discovery and the purpose of this book is to highlight the most important developments. It provides a valuable resource for scientists in academia and industry who are looking to build their knowledge of this hot topic. The individual chapters cover crucial areas including chemical proteomics, chemical genetics, post-translational modifications, epigenetics, RNA interference, PROTACS, antibody-drug conjugates, and chemologics. | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a The chemical genetic approach : the interrogation of biological mechanisms with small molecule probes / Martin Fisher and Adam Nelson -- Applications for activity-based probes in drug discovery / L.E. Edgington and M. Bogyo -- Targeted intracellular protein degradation as a potential therapeutic strategy / A.R. Schneekloth and C.M. Crews -- Chemical biology of stem cell modulation / Stephen G. Davies and Angela J. Russell -- Chemical biology of histone modifications / Nathan R. Rose, Christopher J. Schofield and Tom D. Heightman -- Chemologics / Lyn H. Jones -- Antibody-drug conjugates in oncology / Philip R. Hamann and Russell G. Dushin -- Drug discovery by DNA-encoded libraries / Yizhou Li, Zheng Zhu and Xiaoyu Li. | |
| 546 | |a English. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Drugs |x Design. | |
| 650 | 0 | |a Pharmaceutical chemistry. | |
| 650 | 0 | |a Pharmacology. | |
| 650 | 0 | |a Chemistry. | |
| 650 | 0 | |a Physical sciences. | |
| 650 | 0 | |a Life sciences. | |
| 650 | 0 | |a Structure-activity relationships (Biochemistry) | |
| 650 | 2 | |a Laboratory Chemicals | |
| 650 | 2 | |a Chemistry, Pharmaceutical | |
| 650 | 2 | |a Genetic Phenomena | |
| 650 | 2 | |a Investigative Techniques | |
| 650 | 2 | |a Biochemical Phenomena | |
| 650 | 2 | |a Pharmacological Phenomena | |
| 650 | 2 | |a Phenomena and Processes | |
| 650 | 2 | |a Analytical, Diagnostic and Therapeutic Techniques and Equipment | |
| 650 | 2 | |a Specialty Uses of Chemicals | |
| 650 | 2 | |a Pharmacology | |
| 650 | 2 | |a Chemistry | |
| 650 | 2 | |a Chemical Phenomena | |
| 650 | 2 | |a Physiological Phenomena | |
| 650 | 2 | |a Chemical Actions and Uses | |
| 650 | 2 | |a Natural Science Disciplines | |
| 650 | 2 | |a Biological Science Disciplines | |
| 650 | 2 | |a Chemicals and Drugs | |
| 650 | 2 | |a Disciplines and Occupations | |
| 650 | 2 | |a Structure-Activity Relationship | |
| 650 | 2 | |a Small Molecule Libraries | |
| 650 | 2 | |a Drug Discovery | |
| 650 | 2 | |a Genetic Structures | |
| 650 | 2 | |a Drug Design | |
| 650 | 6 | |a Médicaments |x Conception. | |
| 650 | 6 | |a Chimie pharmaceutique. | |
| 650 | 6 | |a Pharmacologie. | |
| 650 | 6 | |a Chimie. | |
| 650 | 6 | |a Sciences physiques. | |
| 650 | 6 | |a Sciences de la vie. | |
| 650 | 6 | |a Relations structure-activité (Biochimie) | |
| 650 | 7 | |a pharmacology. |2 aat | |
| 650 | 7 | |a chemistry. |2 aat | |
| 650 | 7 | |a physical sciences. |2 aat | |
| 650 | 7 | |a biological sciences. |2 aat | |
| 650 | 7 | |a MEDICAL |x Drug Guides. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Nursing |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Pharmacy. |2 bisacsh | |
| 650 | 7 | |a Structure-activity relationships (Biochemistry) |2 fast | |
| 650 | 7 | |a Physical sciences |2 fast | |
| 650 | 7 | |a Pharmacology |2 fast | |
| 650 | 7 | |a Life sciences |2 fast | |
| 650 | 7 | |a Chemistry |2 fast | |
| 650 | 7 | |a Drugs |x Design |2 fast | |
| 650 | 7 | |a Pharmaceutical chemistry |2 fast | |
| 700 | 1 | |a Bunnage, Mark E. | |
| 700 | 1 | |a Thurston, David E. | |
| 700 | 1 | |a Fox, David. | |
| 758 | |i has work: |a New frontiers in chemical biology (Text) |1 https://id.oclc.org/worldcat/entity/E39PCGdPRYjRFPgkvqwBFp3WQm |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 830 | 0 | |a RSC drug discovery series ; |v 5. | |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=1185804 |z Texto completo |
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| 994 | |a 92 |b IZTAP | ||