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BACE : Lead Target for Orchestrated Therapy of Alzheimer's Disease /
BACE inhibitors and their use in the treatment of Alzheimer's Disease. BACE (ß-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated The...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, N.J. :
John Wiley & Sons,
©2010.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo
- Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha
- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski
- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott
- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig
- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli
- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head
- Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont
- Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu
- Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon [and others].