BACE : Lead Target for Orchestrated Therapy of Alzheimer's Disease /

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BACE inhibitors and their use in the treatment of Alzheimer's Disease. BACE (ß-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated The...

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Bibliographic Details
Call Number:Libro Electrónico
Other Authors: John, Varghese, 1958-
Format: Electronic eBook
Language:Inglés
Published: Hoboken, N.J. : John Wiley & Sons, ©2010.
Subjects:
Alzheimer's disease > Chemotherapy.
Aspartic proteinases > Inhibitors > Therapeutic use.
Amyloid beta-protein precursor.
Alzheimer Disease > drug therapy
Amyloid Precursor Protein Secretases > pharmacology
Amyloid Precursor Protein Secretases > therapeutic use
Amyloid beta-Protein Precursor
Maladie d'Alzheimer > Chimiothérapie.
Précurseur de la protéine bêta amyloïde.
MEDICAL > Geriatrics.
MEDICAL > Nursing > Gerontology.
Alzheimer's disease > Chemotherapy
Amyloid beta-protein precursor
Online Access:Texto completo
Table of Contents:
  • BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo
  • Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha
  • BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski
  • Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott
  • Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig
  • Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli
  • Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head
  • Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont
  • Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu
  • Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon [and others].

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