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BACE : Lead Target for Orchestrated Therapy of Alzheimer's Disease /

BACE inhibitors and their use in the treatment of Alzheimer's Disease. BACE (ß-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated The...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: John, Varghese, 1958-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, N.J. : John Wiley & Sons, ©2010.
Temas:
Acceso en línea:Texto completo

MARC

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245 0 0 |a BACE :  |b Lead Target for Orchestrated Therapy of Alzheimer's Disease /  |c edited by Varghese John. 
246 3 0 |a Beta-site APP Cleaving Enzyme 
260 |a Hoboken, N.J. :  |b John Wiley & Sons,  |c ©2010. 
300 |a 1 online resource (1 electronic resource (xvi, 250 pages, 16 unnumbered pages of plates)) :  |b illustrations (some color) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a data file  |2 rda 
380 |a Bibliography 
504 |a Includes bibliographical references and index. 
505 0 |a BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo -- Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha -- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski -- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott -- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig -- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli -- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head -- Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont -- Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu -- Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon [and others]. 
588 0 |a Print version record. 
520 |a BACE inhibitors and their use in the treatment of Alzheimer's Disease. BACE (ß-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and. 
506 |a Access restricted to Ryerson students, faculty and staff.  |5 CaOTR 
546 |a English. 
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650 0 |a Alzheimer's disease  |x Chemotherapy. 
650 0 |a Aspartic proteinases  |x Inhibitors  |x Therapeutic use. 
650 0 |a Amyloid beta-protein precursor. 
650 1 2 |a Alzheimer Disease  |x drug therapy 
650 2 2 |a Amyloid Precursor Protein Secretases  |x pharmacology 
650 2 2 |a Amyloid Precursor Protein Secretases  |x therapeutic use 
650 2 |a Amyloid beta-Protein Precursor 
650 6 |a Maladie d'Alzheimer  |x Chimiothérapie. 
650 6 |a Précurseur de la protéine bêta amyloïde. 
650 7 |a MEDICAL  |x Geriatrics.  |2 bisacsh 
650 7 |a MEDICAL  |x Nursing  |x Gerontology.  |2 bisacsh 
650 7 |a Alzheimer's disease  |x Chemotherapy  |2 fast 
650 7 |a Amyloid beta-protein precursor  |2 fast 
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