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Evaluation of drug candidates for preclinical development : pharmacokinetics, metabolism, pharmaceutics, and toxicology /
Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, dr...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, N.J. :
John Wiley & Sons,
©2010.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 037 | |a 10.1002/9780470574898 |b Wiley InterScience |n http://www3.interscience.wiley.com | ||
| 050 | 4 | |a RM301.25 |b .E93 2010 | |
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| 049 | |a UAMI | ||
| 245 | 0 | 0 | |a Evaluation of drug candidates for preclinical development : |b pharmacokinetics, metabolism, pharmaceutics, and toxicology / |c [edited by] Chao Han, Charles B. Davis, Binghe Wang. |
| 260 | |a Hoboken, N.J. : |b John Wiley & Sons, |c ©2010. | ||
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 500 | |a Includes index. | ||
| 505 | 0 | |a Pharmacokinetics in preclinical drug development : an overview / Dion Brocks -- The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You -- Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke -- The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan -- Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani -- Prediction of the pharmacokinetics in humans / Chao Han and Remash Bambal -- Pharmaceutics developability assessment / Lian Huang, Jinquan Dong, and Shyam Karki -- Safety assessment in drug discovery / Vito G. Sasseville, William R. Foster, Bruce D. Car -- Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes / Khuram W. Chaudhary and Barry S. Brown. | |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug developmen. | ||
| 588 | 0 | |a Print version record. | |
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Drug development. | |
| 650 | 0 | |a Pharmacokinetics. | |
| 650 | 0 | |a Drugs |x Metabolism. | |
| 650 | 1 | 2 | |a Drug Evaluation, Preclinical |
| 650 | 2 | |a Pharmacokinetics | |
| 650 | 2 | 2 | |a Drug Discovery |
| 650 | 2 | 2 | |a Drug Industry |x standards |
| 650 | 2 | 2 | |a Pharmaceutical Preparations |x metabolism |
| 650 | 2 | 2 | |a Pharmacology |x methods |
| 650 | 6 | |a Médicaments |x Développement. | |
| 650 | 6 | |a Pharmacocinétique. | |
| 650 | 6 | |a Médicaments |x Métabolisme. | |
| 650 | 7 | |a MEDICAL |x Drug Guides. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Pharmacy. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Nursing |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a Drug development |2 fast | |
| 650 | 7 | |a Drugs |x Metabolism |2 fast | |
| 650 | 7 | |a Pharmacokinetics |2 fast | |
| 700 | 1 | |a Han, Chao. | |
| 700 | 1 | |a Davis, Charles B. |q (Charles Baldwin) | |
| 700 | 1 | |a Wang, Binghe, |d 1962- | |
| 758 | |i has work: |a Evaluation of drug candidates for preclinical development (Text) |1 https://id.oclc.org/worldcat/entity/E39PCFytK8dFJM3Xym4MDRDT9C |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |t Evaluation of drug candidates for preclinical development. |d Hoboken, N.J. : John Wiley & Sons, ©2010 |z 9780470044919 |z 0470044918 |w (DLC) 2009035876 |w (OCoLC)435728364 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=479843 |z Texto completo |
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